Trajectories of Alcohol Involvement from Middle Childhood to Early Adulthood: A Multimodal Investigation

从中期儿童到成年早期的饮酒轨迹：多模式调查

• 批准号: 10505841
• 负责人: Sarah Emily Paul
• 金额: $ 4.04万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-08 至 2025-09-07
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10505841
• 关键词: Address; Adolescence; Adolescent; Adolescent and Young Adult; Advanced Development; Alcohol abuse; Alcohol consumption; Alcohols; Amygdaloid structure; Aptitude; Area; Behavior; Behavioral; Behavioral Mechanisms; Bioinformatics; Biological; Brain; Childhood; Clinical; Communities; Competence; Corpus striatum structure; Data; Data Set; Development; Developmental Process; Emotions; Equation; Esthesia; Etiology; Executive Dysfunction; Familiarity; Fostering; Funding; Genome; Genomics; Goals; Heritability; Impulsivity; Individual Differences; Insula of Reil; Intoxication; Investigation; Knowledge; Link; Mediating; Methodology; Methods; Modeling; Neurobiology; Pattern; Phenotype; Policies; Predisposition; Prefrontal Cortex; Prevention; Public Health; Regulation; Research; Research Personnel; Rewards; Risk; Risk-Taking; Sampling; Side; Structure; Surface; Techniques; Testing; Thick; Training; Transact; United States National Institutes of Health; Ventral Striatum; Withdrawal; Youth; addiction; alcohol effect; alcohol involvement; alcohol risk; alcohol use disorder; alcohol use initiation; base; behavior influence; behavioral phenotyping; career; cognitive control; cognitive development; cognitive reappraisal; emerging adult; executive function; genetic variant; genetics of alcoholism; genome wide association study; improved; insight; longitudinal analysis; longitudinal dataset; middle childhood; multimodality; negative affect; neural patterning; neurodevelopment; neuroimaging; neurotoxic; novel; personalized medicine; personalized pharmacotherapy; prevent; programs; relating to nervous system; statistics; substance use; theories; trait; underage drinking; young adult

Project Summary/Abstract Problematic alcohol use is a growing public health concern that typically begins during adolescence/young adulthood. Typical brain maturation patterns wherein emotion- and reward-related regions are prioritized over those relevant to cognitive control and regulation have been linked to developmental risk for alcohol involvement as well as neurotoxic effects of alcohol. The extent to which alcohol involvement results from individual differences in genomically-conferred brain development and related behavioral phenotypes and/or modifies neural trajectories and behavior is not clear. Longitudinal, genetically informed research can address these questions by examining developmental trajectories of alcohol involvement and related risks and consequences. The overarching aim of this investigation is to examine: (a) whether polygenic vulnerability to stage-based behavioral and structural neural phenotypes are related to trajectories of alcohol involvement (i.e., initiation, escalation, problematic use, desistance) from late childhood through young adulthood, and (b) the extent to which these behavioral and neural indicators share genomic liability with stages of alcohol involvement. Through the use of state-of-the-art genomic techniques and the integration of three well-powered, longitudinal datasets with idiosyncratic strengths alongside several genome-side association studies of alcohol involvement, brain structure, and behavior, this multimodal, interdisciplinary investigation aims to yield novel insights about biological and behavioral mechanisms underlying and transacting with alcohol involvement trajectories. Results from the proposed project have the potential to inform the etiologic conceptualization of adolescent and young adult alcohol involvement and improve prevention and treatment as well as relevant policy and educational efforts. The realization of this project will be achieved through the following training goals: (1) to acquire expert knowledge about alcohol involvement and related brain structure and behavior, (2) to promote competence in advance quantitative (e.g., longitudinal) analysis, (3) to gain training in cutting-edge genomic methodology, (4) to augment familiarity with methods of structural neuroimaging, and (5) to promote professional development as the applicant progresses toward a career as an independent, NIH-funded academic researcher. The training team assembled to assist the applicant in achieving these goals has substantial expertise in alcohol use trajectories, brain structure, and longitudinal and genomic techniques. With their support, the applicant will develop the phenotypic, analytic, and professional aptitude needed to foster her research program and career ambitions.

项目摘要/摘要 有问题的饮酒是一个日益增长的公共卫生问题，通常在青春期/Young期间开始 成年。典型的大脑成熟模式，将情感和奖励相关区域优先考虑 与认知控制和法规相关的人与酒精参与的发育风险有关 以及酒精的神经毒性作用。酒精参与的程度是由个体引起的 基因组限制的大脑发育和相关行为表型和/或修改的差异 神经轨迹和行为尚不清楚。纵向，遗传知情的研究可以解决这些 通过检查酒精参与以及相关风险和后果的发展轨迹来进行问题。 这项调查的总体目的是检查：（a）多基因脆弱性是否存在基于阶段的脆弱性 行为和结构神经表型与酒精参与的轨迹有关（即起始， 从童年后期到成年后的升级，有问题的使用，避免），以及（b） 这些行为和神经指标具有基因组责任，伴随着酒精的参与。通过 最先进的基因组技术以及三个纵向数据集的集成 具有特质强度，以及酒精参与的几个基因组侧关联研究，大脑 结构和行为，这种多模式的跨学科研究旨在产生有关的新见解 与酒精参与轨迹进行的生物学和行为机制。结果 来自拟议的项目有可能告知青少年和年轻的病因概念化 成人酒精参与并改善预防和治疗以及相关政策和教育 努力。通过以下培训目标实现该项目的实现：（1）获取专家 关于酒精参与以及相关的大脑结构和行为的知识，（2）促进能力 提前定量（例如，纵向）分析，（3）获得尖端基因组方法的培训，（4） 增强对结构神经影像方法的熟悉，（5）促进专业发展作为 申请人作为一名独立的NIH资助的学术研究员迈向职业。培训 团队组装以协助申请人实现这些目标具有丰富的酒精使用专业知识 轨迹，大脑结构以及纵向和基因组技术。在他们的支持下，申请人将 开发培养她的研究计划和职业所需的表型，分析和专业能力 野心。