Trajectories of Alcohol Involvement from Middle Childhood to Early Adulthood: A Multimodal Investigation

从中期儿童到成年早期的饮酒轨迹：多模式调查

• 批准号: 10505841
• 负责人: Sarah Emily Paul
• 金额: $ 4.04万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-08 至 2025-09-07
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10505841
• 关键词: Address; Adolescence; Adolescent; Adolescent and Young Adult; Advanced Development; Alcohol abuse; Alcohol consumption; Alcohols; Amygdaloid structure; Aptitude; Area; Behavior; Behavioral; Behavioral Mechanisms; Bioinformatics; Biological; Brain; Childhood; Clinical; Communities; Competence; Corpus striatum structure; Data; Data Set; Development; Developmental Process; Emotions; Equation; Esthesia; Etiology; Executive Dysfunction; Familiarity; Fostering; Funding; Genome; Genomics; Goals; Heritability; Impulsivity; Individual Differences; Insula of Reil; Intoxication; Investigation; Knowledge; Link; Mediating; Methodology; Methods; Modeling; Neurobiology; Pattern; Phenotype; Policies; Predisposition; Prefrontal Cortex; Prevention; Public Health; Regulation; Research; Research Personnel; Rewards; Risk; Risk-Taking; Sampling; Side; Structure; Surface; Techniques; Testing; Thick; Training; Transact; United States National Institutes of Health; Ventral Striatum; Withdrawal; Youth; addiction; alcohol effect; alcohol involvement; alcohol risk; alcohol use disorder; alcohol use initiation; base; behavior influence; behavioral phenotyping; career; cognitive control; cognitive development; cognitive reappraisal; emerging adult; executive function; genetic variant; genetics of alcoholism; genome wide association study; improved; insight; longitudinal analysis; longitudinal dataset; middle childhood; multimodality; negative affect; neural patterning; neurodevelopment; neuroimaging; neurotoxic; novel; personalized medicine; personalized pharmacotherapy; prevent; programs; relating to nervous system; statistics; substance use; theories; trait; underage drinking; young adult

Project Summary/Abstract Problematic alcohol use is a growing public health concern that typically begins during adolescence/young adulthood. Typical brain maturation patterns wherein emotion- and reward-related regions are prioritized over those relevant to cognitive control and regulation have been linked to developmental risk for alcohol involvement as well as neurotoxic effects of alcohol. The extent to which alcohol involvement results from individual differences in genomically-conferred brain development and related behavioral phenotypes and/or modifies neural trajectories and behavior is not clear. Longitudinal, genetically informed research can address these questions by examining developmental trajectories of alcohol involvement and related risks and consequences. The overarching aim of this investigation is to examine: (a) whether polygenic vulnerability to stage-based behavioral and structural neural phenotypes are related to trajectories of alcohol involvement (i.e., initiation, escalation, problematic use, desistance) from late childhood through young adulthood, and (b) the extent to which these behavioral and neural indicators share genomic liability with stages of alcohol involvement. Through the use of state-of-the-art genomic techniques and the integration of three well-powered, longitudinal datasets with idiosyncratic strengths alongside several genome-side association studies of alcohol involvement, brain structure, and behavior, this multimodal, interdisciplinary investigation aims to yield novel insights about biological and behavioral mechanisms underlying and transacting with alcohol involvement trajectories. Results from the proposed project have the potential to inform the etiologic conceptualization of adolescent and young adult alcohol involvement and improve prevention and treatment as well as relevant policy and educational efforts. The realization of this project will be achieved through the following training goals: (1) to acquire expert knowledge about alcohol involvement and related brain structure and behavior, (2) to promote competence in advance quantitative (e.g., longitudinal) analysis, (3) to gain training in cutting-edge genomic methodology, (4) to augment familiarity with methods of structural neuroimaging, and (5) to promote professional development as the applicant progresses toward a career as an independent, NIH-funded academic researcher. The training team assembled to assist the applicant in achieving these goals has substantial expertise in alcohol use trajectories, brain structure, and longitudinal and genomic techniques. With their support, the applicant will develop the phenotypic, analytic, and professional aptitude needed to foster her research program and career ambitions.

项目总结/文摘