The role of solitary chemosensory cells in periodontal homeostasis

孤立化学感应细胞在牙周稳态中的作用

基本信息

  • 批准号:
    10542979
  • 负责人:
  • 金额:
    $ 32.65万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-01-01 至 2025-04-30
  • 项目状态:
    未结题

项目摘要

Project Summary Periodontal disease, which results from bacterial infection and inflammation of the gums and bone that surround and support the teeth, affects nearly half of US adults over 30, with ~9% having severe periodontitis. The hallmark of periodontitis is destruction of alveolar bone, resulting ultimately in extended tooth loss and oral disability. Periodontitis is a major oral health problem, particularly among the elderly, that increases the risk for systemic diseases, including atherosclerosis, rheumatoid arthritis, and diabetes mellitus. The general goals of this grant are to determine the role of newly discovered gingival solitary chemosensory cells (gSCCs) in protecting against periodontitis, to identify the receptors, signaling pathways and effectors involved in innate immunity evoked by gSCC activation, and to identify compounds that activate gSCCs to harness host innate immunity to reduce periodontitis. Periodontitis results from polymicrobial dysbiosis, which perturbs the ecologically balanced oral microbiota, and from disruption of the host innate immunity, which also contributes to the destruction of periodontal tissue. While much is known about how microbes and host immunity contribute to periodontitis, it is still unclear which gingival cells protect against the disease. Recent studies in several types of mucosae have identified taste cell-like SCCs as specialized chemosensitive sentinel cells that detect bacteria and evoke host innate immune responses. Most recently, we have identified gSCCs in the mouse gingival junctional epithelium that is part of the epithelial barrier protecting against bacterial infection of the tooth and surrounding gingiva. gSCCs express bitter taste receptors along with other taste transduction components, respond to bacterial signaling molecules, and trigger intrinsic innate immunity to protect against periodontitis. The experiments of this proposal study the role of gSCCs in gingival/tooth health to determine if gSCCs evoke innate immune responses that prevent overgrowth of oral bacteria in the gingival mucosa (Aim 1); identify the receptors and signaling components of gSCCs and the mechanism by which gSCCs promote gingival release of antimicrobial peptides and inflammatory cytokines (Aim 2); and determine if “on demand “activation of the gSCC signaling pathway reduces periodontitis (Aim 3). Understanding the initiating receptors and underlying mechanisms of these responses may lead to new approaches to promote oral health and treat periodontitis.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Robert F. Margolskee其他文献

Paxlovid mouth likely is mediated by activation of the TAS2R1 bitter receptor by nirmatrelvir
  • DOI:
    10.1016/j.bbrc.2023.10.001
  • 发表时间:
    2023-11-19
  • 期刊:
  • 影响因子:
  • 作者:
    Lauren Caronia;Ranhui Xi;Robert F. Margolskee;Peihua Jiang
  • 通讯作者:
    Peihua Jiang
Involvement of phosphoinositide 3-kinase in leptin signaling in sweet sensitive taste cells
磷酸肌醇 3-激酶参与甜味敏感味觉细胞瘦素信号传导
  • DOI:
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Ryusuke Yoshida;Robert F. Margolskee;Yuzo Ninomiya
  • 通讯作者:
    Yuzo Ninomiya
マウス味細胞応答に対するレプチンの効果
瘦素对小鼠味觉细胞反应的影响
  • DOI:
  • 发表时间:
    2012
  • 期刊:
  • 影响因子:
    0
  • 作者:
    吉田竜介;高井信吾;仁木麻由;Robert F. Margolskee;二ノ宮裕三
  • 通讯作者:
    二ノ宮裕三
Gustducinを介さない苦味情報伝達系のlicking解析による評価
通过舔分析评价非味素介导的苦味信息传递系统
  • DOI:
  • 发表时间:
    2010
  • 期刊:
  • 影响因子:
    0
  • 作者:
    大木誠;三浦裕仁;友成博;中山歩;Robert F. Margolskee;二ノ宮裕三;原田秀逸
  • 通讯作者:
    原田秀逸
PRP療法の現状と課題
PRP治疗的现状及问题
  • DOI:
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Ryusuke Yoshida;Robert F. Margolskee;Yuzo Ninomiya;楠本健司
  • 通讯作者:
    楠本健司

Robert F. Margolskee的其他文献

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{{ truncateString('Robert F. Margolskee', 18)}}的其他基金

The role of solitary chemosensory cells in periodontal homeostasis
孤立化学感应细胞在牙周稳态中的作用
  • 批准号:
    10386876
  • 财政年份:
    2022
  • 资助金额:
    $ 32.65万
  • 项目类别:
The role of solitary chemosensory cells in periodontal homeostasis
孤立化学感应细胞在牙周稳态中的作用
  • 批准号:
    10614064
  • 财政年份:
    2022
  • 资助金额:
    $ 32.65万
  • 项目类别:
The role of solitary chemosensory cells in periodontal homeostasis
孤立化学感应细胞在牙周稳态中的作用
  • 批准号:
    10202559
  • 财政年份:
    2020
  • 资助金额:
    $ 32.65万
  • 项目类别:
Pathways and genes of sweet taste cells
甜味细胞的通路和基因
  • 批准号:
    9232128
  • 财政年份:
    2015
  • 资助金额:
    $ 32.65万
  • 项目类别:
Core Center for Chemical Senses
化学感官核心中心
  • 批准号:
    8158643
  • 财政年份:
    2011
  • 资助金额:
    $ 32.65万
  • 项目类别:
Core Center for Chemical Senses
化学感官核心中心
  • 批准号:
    8681194
  • 财政年份:
    2011
  • 资助金额:
    $ 32.65万
  • 项目类别:
Core Center for Chemical Senses
化学感官核心中心
  • 批准号:
    8491768
  • 财政年份:
    2011
  • 资助金额:
    $ 32.65万
  • 项目类别:
Core Center for Chemical Senses
化学感官核心中心
  • 批准号:
    8479478
  • 财政年份:
    2011
  • 资助金额:
    $ 32.65万
  • 项目类别:
Core Center for Chemical Senses
化学感官核心中心
  • 批准号:
    8294729
  • 财政年份:
    2011
  • 资助金额:
    $ 32.65万
  • 项目类别:
Role of taste signaling elements in enteroendocrine cells
味觉信号元件在肠内分泌细胞中的作用
  • 批准号:
    8067065
  • 财政年份:
    2010
  • 资助金额:
    $ 32.65万
  • 项目类别:

相似国自然基金

针刺的双向调节效应研究
  • 批准号:
    30472244
  • 批准年份:
    2004
  • 资助金额:
    18.0 万元
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相似海外基金

The role of solitary chemosensory cells in periodontal homeostasis
孤立化学感应细胞在牙周稳态中的作用
  • 批准号:
    10386876
  • 财政年份:
    2022
  • 资助金额:
    $ 32.65万
  • 项目类别:
The role of solitary chemosensory cells in periodontal homeostasis
孤立化学感应细胞在牙周稳态中的作用
  • 批准号:
    10614064
  • 财政年份:
    2022
  • 资助金额:
    $ 32.65万
  • 项目类别:
Solitary chemosensory cell development and function
孤立化学感应细胞的发育和功能
  • 批准号:
    10194193
  • 财政年份:
    2021
  • 资助金额:
    $ 32.65万
  • 项目类别:
Solitary chemosensory cell development and function
孤立化学感应细胞的发育和功能
  • 批准号:
    10379276
  • 财政年份:
    2021
  • 资助金额:
    $ 32.65万
  • 项目类别:
The role of solitary chemosensory cells in periodontal homeostasis
孤立化学感应细胞在牙周稳态中的作用
  • 批准号:
    10202559
  • 财政年份:
    2020
  • 资助金额:
    $ 32.65万
  • 项目类别:
Solitary Chemosensory Cell Regulation of Airway Inflammation and Repair
气道炎症和修复的孤立化学感应细胞调节
  • 批准号:
    10542437
  • 财政年份:
    2020
  • 资助金额:
    $ 32.65万
  • 项目类别:
Solitary Chemosensory Cell Regulation of Airway Inflammation and Repair
气道炎症和修复的孤立化学感应细胞调节
  • 批准号:
    10320452
  • 财政年份:
    2020
  • 资助金额:
    $ 32.65万
  • 项目类别:
Role of solitary chemosensory cells in irritant avoidance and protection of olfactory sensation
孤立化学感应细胞在避免刺激和保护嗅觉中的作用
  • 批准号:
    9756360
  • 财政年份:
    2017
  • 资助金额:
    $ 32.65万
  • 项目类别:
Role of solitary chemosensory cells in irritant avoidance and protection of olfactory sensation
孤立化学感应细胞在避免刺激和保护嗅觉中的作用
  • 批准号:
    10542981
  • 财政年份:
    2017
  • 资助金额:
    $ 32.65万
  • 项目类别:
Role of solitary chemosensory cells in irritant avoidance and protection of olfactory sensation
孤立化学感应细胞在避免刺激和保护嗅觉中的作用
  • 批准号:
    10228706
  • 财政年份:
    2017
  • 资助金额:
    $ 32.65万
  • 项目类别:
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