The role of solitary chemosensory cells in periodontal homeostasis
孤立化学感应细胞在牙周稳态中的作用
基本信息
- 批准号:10386876
- 负责人:
- 金额:$ 52万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-01-01 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:AdultAffectAgeAirAlveolar Bone LossAnti-Bacterial AgentsAtherosclerosisBacteriaBacterial InfectionsCellsCycloheximideDendritic CellsDiabetes MellitusDiseaseElderlyElementsEpithelialEpithelial AttachmentFoundationsGene ExpressionGingivaGoalsGrantGrowthHealthHeterogeneityHomeostasisImmuneImmunityImmunohistochemistryImpairmentIn Situ HybridizationIn VitroInflammationInflammatoryInnate Immune ResponseKnock-outKnockout MiceLactonesLeadLigandsLiquid substanceLymphoid CellMediator of activation proteinMicrobeMucous MembraneMusNatural ImmunityOralOral healthPathway interactionsPeriodontal DiseasesPeriodontitisPopulationReceptor CellReceptor SignalingResearchRheumatoid ArthritisRiskRisk FactorsRoleScienceSentinelSignal PathwaySignal TransductionSignaling MoleculeSystemic diseaseTaste BudsTaste PerceptionTestingTissuesTooth LossTooth structureTopical applicationWild Type MouseWorkalveolar bonealveolar destructionantimicrobial peptidebasebonebone losschemokinecytokinedisabilitydysbiosisexperimental studyhomoserine lactoneknockout genemacrophagemicrobialmicrobiome compositionmouse modelnovel strategiesoral bacteriaoral microbial communityoral microbiomepathogenpeptide Bpreventprotective effectquorum sensingreceptorresponseselective expressiontaste transductiontranscriptomics
项目摘要
Project Summary
Periodontal disease, which results from bacterial infection and inflammation of the gums and bone that
surround and support the teeth, affects nearly half of US adults over 30, with ~9% having severe periodontitis.
The hallmark of periodontitis is destruction of alveolar bone, resulting ultimately in extended tooth loss and oral
disability. Periodontitis is a major oral health problem, particularly among the elderly, that increases the risk for
systemic diseases, including atherosclerosis, rheumatoid arthritis, and diabetes mellitus. The general goals of
this grant are to determine the role of newly discovered gingival solitary chemosensory cells (gSCCs) in
protecting against periodontitis, to identify the receptors, signaling pathways and effectors involved in innate
immunity evoked by gSCC activation, and to identify compounds that activate gSCCs to harness host innate
immunity to reduce periodontitis.
Periodontitis results from polymicrobial dysbiosis, which perturbs the ecologically balanced oral
microbiota, and from disruption of the host innate immunity, which also contributes to the destruction of
periodontal tissue. While much is known about how microbes and host immunity contribute to periodontitis, it is
still unclear which gingival cells protect against the disease. Recent studies in several types of mucosae have
identified taste cell-like SCCs as specialized chemosensitive sentinel cells that detect bacteria and evoke host
innate immune responses.
Most recently, we have identified gSCCs in the mouse gingival junctional epithelium that is part of the
epithelial barrier protecting against bacterial infection of the tooth and surrounding gingiva. gSCCs express
bitter taste receptors along with other taste transduction components, respond to bacterial signaling molecules,
and trigger intrinsic innate immunity to protect against periodontitis. The experiments of this proposal study the
role of gSCCs in gingival/tooth health to determine if gSCCs evoke innate immune responses that prevent
overgrowth of oral bacteria in the gingival mucosa (Aim 1); identify the receptors and signaling components of
gSCCs and the mechanism by which gSCCs promote gingival release of antimicrobial peptides and
inflammatory cytokines (Aim 2); and determine if “on demand “activation of the gSCC signaling pathway
reduces periodontitis (Aim 3). Understanding the initiating receptors and underlying mechanisms of these
responses may lead to new approaches to promote oral health and treat periodontitis.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Robert F. Margolskee其他文献
Paxlovid mouth likely is mediated by activation of the TAS2R1 bitter receptor by nirmatrelvir
- DOI:
10.1016/j.bbrc.2023.10.001 - 发表时间:
2023-11-19 - 期刊:
- 影响因子:
- 作者:
Lauren Caronia;Ranhui Xi;Robert F. Margolskee;Peihua Jiang - 通讯作者:
Peihua Jiang
Involvement of phosphoinositide 3-kinase in leptin signaling in sweet sensitive taste cells
磷酸肌醇 3-激酶参与甜味敏感味觉细胞瘦素信号传导
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
Ryusuke Yoshida;Robert F. Margolskee;Yuzo Ninomiya - 通讯作者:
Yuzo Ninomiya
マウス味細胞応答に対するレプチンの効果
瘦素对小鼠味觉细胞反应的影响
- DOI:
- 发表时间:
2012 - 期刊:
- 影响因子:0
- 作者:
吉田竜介;高井信吾;仁木麻由;Robert F. Margolskee;二ノ宮裕三 - 通讯作者:
二ノ宮裕三
Gustducinを介さない苦味情報伝達系のlicking解析による評価
通过舔分析评价非味素介导的苦味信息传递系统
- DOI:
- 发表时间:
2010 - 期刊:
- 影响因子:0
- 作者:
大木誠;三浦裕仁;友成博;中山歩;Robert F. Margolskee;二ノ宮裕三;原田秀逸 - 通讯作者:
原田秀逸
PRP療法の現状と課題
PRP治疗的现状及问题
- DOI:
- 发表时间:
2020 - 期刊:
- 影响因子:0
- 作者:
Ryusuke Yoshida;Robert F. Margolskee;Yuzo Ninomiya;楠本健司 - 通讯作者:
楠本健司
Robert F. Margolskee的其他文献
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{{ truncateString('Robert F. Margolskee', 18)}}的其他基金
The role of solitary chemosensory cells in periodontal homeostasis
孤立化学感应细胞在牙周稳态中的作用
- 批准号:
10542979 - 财政年份:2022
- 资助金额:
$ 52万 - 项目类别:
The role of solitary chemosensory cells in periodontal homeostasis
孤立化学感应细胞在牙周稳态中的作用
- 批准号:
10614064 - 财政年份:2022
- 资助金额:
$ 52万 - 项目类别:
The role of solitary chemosensory cells in periodontal homeostasis
孤立化学感应细胞在牙周稳态中的作用
- 批准号:
10202559 - 财政年份:2020
- 资助金额:
$ 52万 - 项目类别:
Role of taste signaling elements in enteroendocrine cells
味觉信号元件在肠内分泌细胞中的作用
- 批准号:
8067065 - 财政年份:2010
- 资助金额:
$ 52万 - 项目类别:
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