Core Center for Chemical Senses

化学感官核心中心

基本信息

批准号：
8479478
负责人：
Robert F. Margolskee
金额：
$ 14.89万
依托单位：
MONELL CHEMICAL SENSES CENTER
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-05 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8479478
关键词：
Animal Model Area Basic Science Biochemistry Biological Assay Biological Models Cancer Grant Supplements (P30)Cell Culture Techniques Cells Chemical Engineering Chemicals Complement Cultured Cells DNA Disease Ecology Endocrinology Ensure Faculty Funding Gene Expression Gene Targeting Generations Genes Genetic Genome Genotype Goals Grant Histology Immunology In Vitro Individual Institutes Knock-in Mouse Knock-out Knockout Mice Ligands Mammalian Cell Methods Microbiology Mission Molecular Molecular Biology Mus Mutagenesis Neurosciences New England Odorant Receptors Organic Chemistry Pennsylvania Pharmacology Phenotype Physiology Production Productivity Protein Engineering Proteins Protocols documentation Psychophysics RNA analysis Rattus Receptor Gene Receptor Signaling Research Research Personnel Research Project Grants Services Signal Transduction Small Interfering RNA System Tamoxifen Taste Perception Technical Expertise Techniques Tetanus Helper Peptide Tissues Training Transgenic Animals Transgenic Mice Transgenic Organisms Translational Research Universities Ursidae Family Zoology base cost deafness design embryonic stem cell high throughput analysis high throughput screening in vivo interest knockout animal mouse model nutrition olfactory receptor programs promoter public health relevance ranpirnase receptor repository research study screening vector

项目摘要

DESCRIPTION (provided by applicant): The P30 Core Center of the Monell Chemical Senses Center serves a Research Base of nine PIs with sixteen active ROI grants in the NIDCD mission area by providing expertise in the following areas: 1. Histology, 2. Genotyping, 3. Phenotyping. This P30 grant budgetary revision requests funds to support a new Research Core with a focus on Chemosensory Receptor Signaling. The new Chemosensory Receptor Signaling Core will be led jointly by Dr. Bedrich Mosinger (Director), an expert in the use of transgenic and knockout mouse models to study taste receptor genes, and Dr. Joel Mainland (Co-Director), an expert in high throughput analysis of odorant receptor genes in vitro. The Chemosensory Receptor Signaling Core provides PIs in our Research Base with construct generation and related services for in vitro experiments, including high-throughput analysis of odorant and taste receptors, and in vivo experiments, including constructs for transgenics and conditional knockouts of odorant and taste receptor genes. The Core also provides advice and training in these areas to Research Base PIs at Monell, Monell faculty, and their staff. The Core is designed to encourage non-molecular biologists to adapt a variety of molecular techniques for their chemosensory signaling projects. Overall oversight of Monell's P30 Core Center is by Dr. Robert Margolskee, Associate Director of Monell and PI of Monell's P30 Center. He coordinates the activities of Monell's P30 Center and will ensure that the new Chemosensory Receptor Signaling Core is integrated with the existing three Research Cores to provide efficient services and training to the researchers in Monell's Research Base. The expertise and technical capabilities provided by the new Chemosensory Receptor Signaling Core are uniquely well suited to Monell's faculty and the PIs of Monell's Research Base, with their focus on the chemical senses. The new Core, through training and services of users will provide new capabilities and enhance productivity of Monell's researchers. Together these four Research Cores will enhance Monell's research in the chemical senses and further the mission of the NIDCD.

描述（由申请人提供）：Monell Chemical Senses Center的P30核心中心通过在NIDCD任务领域提供的9个PI的研究基础，在以下领域提供专业知识：1。组织学，2。基因分型，3。表型。这项P30赠款预算修订要求资金支持新的研究核心，重点是化学感应受体信号。新的化学感应受体信号传导核心将由Bedrich Mosinger博士（主任）共同领导，该博士是转基因和基因敲除小鼠模型来研究味觉受体基因的专家，Joel Mainland（联合导演）是对体外气味受体基因的高吞吐量分析的专家。化学感受器受体信号传导核心在我们的研究基础中提供了PIS的PIS，并提供了用于体外实验的构建体和相关服务，包括对气味和味觉受体的高通量分析，以及体内实验，包括转基因和有条件敲除味道和味觉受体基因的构造。核心还提供了这些领域的建议和培训，以研究Monell，Monell教职员工及其员工的PIS。核心旨在鼓励非分子生物学家适应各种分子技术，以适应其化学感应信号项目。 Monell的P30 Core Center的总体监督是Monell和Monell P30中心PI副主任Robert Margolskee博士。他协调了Monell的P30中心的活动，并将确保将新的化学感应受体信号核心与现有的三个研究核心集成在一起，以向Monell研究基础的研究人员提供有效的服务和培训。新的化学感应受体信号核心提供的专业知识和技术能力非常适合Monell的教职员工和Monell研究基础的PI，其重点是化学感官。通过用户的培训和服务，新的核心将提供新的功能并提高Monell研究人员的生产率。这四个研究核心将共同增强Monell在化学感官方面的研究，并进一步发展NIDCD的任务。