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Core Center for Chemical Senses

化学感官核心中心

基本信息

批准号：
8479478
负责人：
Robert F. Margolskee
金额：
$ 14.89万
依托单位：
MONELL CHEMICAL SENSES CENTER
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-05 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8479478
关键词：
Animal Model Area Basic Science Biochemistry Biological Assay Biological Models Cancer Grant Supplements (P30)Cell Culture Techniques Cells Chemical Engineering Chemicals Complement Cultured Cells DNA Disease Ecology Endocrinology Ensure Faculty Funding Gene Expression Gene Targeting Generations Genes Genetic Genome Genotype Goals Grant Histology Immunology In Vitro Individual Institutes Knock-in Mouse Knock-out Knockout Mice Ligands Mammalian Cell Methods Microbiology Mission Molecular Molecular Biology Mus Mutagenesis Neurosciences New England Odorant Receptors Organic Chemistry Pennsylvania Pharmacology Phenotype Physiology Production Productivity Protein Engineering Proteins Protocols documentation Psychophysics RNA analysis Rattus Receptor Gene Receptor Signaling Research Research Personnel Research Project Grants Services Signal Transduction Small Interfering RNA System Tamoxifen Taste Perception Technical Expertise Techniques Tetanus Helper Peptide Tissues Training Transgenic Animals Transgenic Mice Transgenic Organisms Translational Research Universities Ursidae Family Zoology base cost deafness design embryonic stem cell high throughput analysis high throughput screening in vivo interest knockout animal mouse model nutrition olfactory receptor programs promoter public health relevance ranpirnase receptor repository research study screening vector

项目摘要

DESCRIPTION (provided by applicant): The P30 Core Center of the Monell Chemical Senses Center serves a Research Base of nine PIs with sixteen active ROI grants in the NIDCD mission area by providing expertise in the following areas: 1. Histology, 2. Genotyping, 3. Phenotyping. This P30 grant budgetary revision requests funds to support a new Research Core with a focus on Chemosensory Receptor Signaling. The new Chemosensory Receptor Signaling Core will be led jointly by Dr. Bedrich Mosinger (Director), an expert in the use of transgenic and knockout mouse models to study taste receptor genes, and Dr. Joel Mainland (Co-Director), an expert in high throughput analysis of odorant receptor genes in vitro. The Chemosensory Receptor Signaling Core provides PIs in our Research Base with construct generation and related services for in vitro experiments, including high-throughput analysis of odorant and taste receptors, and in vivo experiments, including constructs for transgenics and conditional knockouts of odorant and taste receptor genes. The Core also provides advice and training in these areas to Research Base PIs at Monell, Monell faculty, and their staff. The Core is designed to encourage non-molecular biologists to adapt a variety of molecular techniques for their chemosensory signaling projects. Overall oversight of Monell's P30 Core Center is by Dr. Robert Margolskee, Associate Director of Monell and PI of Monell's P30 Center. He coordinates the activities of Monell's P30 Center and will ensure that the new Chemosensory Receptor Signaling Core is integrated with the existing three Research Cores to provide efficient services and training to the researchers in Monell's Research Base. The expertise and technical capabilities provided by the new Chemosensory Receptor Signaling Core are uniquely well suited to Monell's faculty and the PIs of Monell's Research Base, with their focus on the chemical senses. The new Core, through training and services of users will provide new capabilities and enhance productivity of Monell's researchers. Together these four Research Cores will enhance Monell's research in the chemical senses and further the mission of the NIDCD.

描述（由申请人提供）：莫奈尔化学感官中心的P30核心中心通过在以下领域提供专业知识，为NIDCD任务区域的9个pi提供16个积极的ROI资助的研究基地。组织学,2。基因分型,3。表现型。这项P30拨款预算修订要求资金支持一个新的研究核心，重点是化学感觉受体信号。新的化学感觉受体信号中心将由利用转基因和敲除小鼠模型研究味觉受体基因的专家Bedrich Mosinger博士（主任）和体外高通量分析气味受体基因的专家Joel Mainland博士（联席主任）共同领导。化学感觉受体信号传导核心为我们研究基地的pi提供构建体生成和相关服务，用于体外实验，包括气味和味觉受体的高通量分析，以及体内实验，包括转基因构建和条件敲除气味和味觉受体基因。核心还为莫奈尔大学的研究基地pi、莫奈尔大学的教职员工提供这些领域的建议和培训。该核心旨在鼓励非分子生物学家适应各种分子技术，为他们的化学感觉信号项目。莫奈尔P30核心中心的整体监督由莫奈尔副主任兼莫奈尔P30中心的PI Robert Margolskee博士负责。他负责协调莫奈尔P30中心的活动，并将确保新的化学感觉受体信号核心与现有的三个研究核心相结合，为莫奈尔研究基地的研究人员提供有效的服务和培训。新的化学感觉受体信号核心提供的专业知识和技术能力非常适合莫奈尔的教师和莫奈尔研究基地的pi，他们专注于化学感觉。新的核心，通过培训和服务的用户将提供新的能力和提高莫奈尔的研究人员的生产力。这四个研究核心将共同加强莫奈尔在化学感官方面的研究，并进一步推进NIDCD的使命。