Core Center for Chemical Senses

化学感官核心中心

• 批准号: 8491768
• 负责人: Robert F. Margolskee
• 金额: $ 53.67万
• 依托单位: MONELL CHEMICAL SENSES CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-05 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8491768
• 关键词: Animals; Area; Basic Science; Cancer Grant Supplements (P30); Center Core Grants; Chemicals; Chromosome Mapping; Environment; Fostering; Genotype; Grant; Health; Histology; Human; Imagery; Institutes; Lead; Methods; Mission; Molecular Biology; Mus; National Institute on Deafness and Other Communication Disorders; Personal Satisfaction; Phenotype; Principal Investigator; Proteins; Qualifying; Rattus; Receptor Cell; Research; Research Support; Running; Smell Perception; Taste Perception; Technical Expertise; Training; Transgenic Mice; United States National Institutes of Health; Ursidae Family; base; experience; improved; innovation; interdisciplinary collaboration; mouse model; multidisciplinary; trait

The Monell Chemical Senses Center, founded in 1968, is the world's first and only multidisciplinary institute devoted entirely to basic research in the chemical senses and produces extensive research within the NIDCD mission area. Two of Monell's greatest strengths are the breadth of approaches brought to bear on problems in the chemical senses, and the effective interdisciplinary collaborations that are fostered at the Monell Center. In this P30 grant application for a Core Center in the chemical senses, four Research Cores with distinct areas of technical expertise highly relevant to the chemical senses are proposed: 1. Histology, 2. Genotyping, 3. Molecular Biology, and 4. Phenotyping. In addition, an Administrative Core will support the Research Cores in their mission to enhance the research of users in our Research Base of thirteen R01 grants in the NIDCD mission area. Dr. Liquan Huang will lead the Histology Core, building on his expertise in the visualization of proteins in taste receptor cells. The Genotyping Core will be led by Dr. Danielle Reed, who has over twenty years of training and experience with genotyping and gene mapping. Dr. Bedrich Mosinger, an expert in molecular biology and in constructing transgenic mouse models, is the Director of the Molecular Biology Core. Dr. Alexander Bachmanov will run the Phenotyping Core; he is well-known for his ability to phenotype mice and rats for traits relevant to the chemical senses. The Director of the Administrative Core is Dr. Robert Margolskee, who through his expertise in the research areas of all four Research Cores and his administrative experience is uniquely qualified to serve as PI of this Core Center grant. Together these Cores will serve the Research Base at Monell and by contributing to innovative research in the chemical senses further the mission of NIDCD to understand taste, smell and the common chemical sense in order to improve human health and well-being.

莫奈尔化学感官中心成立于1968年，是世界上第一个也是唯一一个完全致力于化学感官基础研究的多学科研究所，并在NIDCD任务范围内进行了广泛的研究。莫奈尔中心最大的两个优势是研究化学感官问题的方法的广度，以及在莫奈尔中心培养的有效的跨学科合作。在这项P30资助申请中，提出了四个与化学感官高度相关的具有不同技术专长领域的研究核心：1。组织学,2。基因分型,3。4.分子生物学；表现型。此外，行政核心将支持研究核心的任务，以加强我们在NIDCD任务地区的13个R01拨款研究基地的用户的研究。黄立全博士将利用他在味觉受体细胞中蛋白质可视化方面的专业知识，领导组织学核心。基因分型核心将由Danielle Reed博士领导，他在基因分型和基因定位方面有20多年的培训和经验。Bedrich Mosinger博士是分子生物学和构建转基因小鼠模型的专家，是分子生物学核心的主任。亚历山大·巴赫马诺夫博士负责表型中心；他以能够对小鼠和大鼠进行与化学感官相关的性状表型分析而闻名。行政核心主任是Robert Margolskee博士，他在所有四个研究核心的研究领域的专业知识和他的行政经验是唯一有资格担任该核心中心拨款的PI。这些核心将共同服务于莫奈尔研究基地，并通过促进化学感官的创新研究，进一步实现NIDCD的使命，即了解味觉、嗅觉和普通化学感官，以改善人类健康和福祉。