Integrating HIV and hEART health in South Africa (iHeart-SA)
在南非整合艾滋病毒和心脏抗逆转录病毒治疗 (iHeart-SA)
基本信息
- 批准号:10508822
- 负责人:
- 金额:$ 83.55万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-25 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdministratorAdoptedAdoptionAdultAfricanAwardAwarenessBlood Glucose Self-MonitoringBlood PressureCardiac healthCardiovascular DiseasesCaringClinicClinicalCollaborationsCommunitiesCountryDetectionDiabetes MellitusDiagnosisDoctor of PhilosophyDocumentationEffectivenessEthicsEventEvidence based interventionFeedbackGlucoseGoalsGovernmentGuidelinesHIVHIV SeronegativityHealth care facilityHomeHumanHuman ResourcesHypertensionIndiaInstitutionInternationalInterventionKnowledgeMaintenanceMeasurementMeasuresMentorshipMeta-AnalysisMethodsModelingModificationMonitorMorbidity - disease rateMotivationNational Heart, Lung, and Blood InstituteOutputOwnershipPatientsPersonsPhasePreparationProtocols documentationProviderPublic SectorPublicationsRandomized Controlled TrialsReach Effectiveness Adoption Implementation and MaintenanceReadinessResearchResearch MethodologyResearch PersonnelResourcesReview LiteratureRiskRisk AssessmentRisk FactorsRisk ReductionRuralScientistSelf ManagementSiteSouth AfricaStrokeStructureSystemTestingTrainingWorkantiretroviral therapybehavior changebudget impactburden of illnesscardiovascular disorder riskcare deliverycluster trialcomorbiditycostcost estimatedesigneffectiveness evaluationexperienceglucose monitorheart disease riskhuman centered designhybrid type 2 designhypertension controlhypertension treatmentimplementation researchimplementation scienceimplementation strategyimprovedinnovationintervention costmeetingsmortalitymultidisciplinarynext generationpandemic diseasepatient-level barriersprimary outcomeprogramsprovider-level barriersresponsescale upscreeningsuccesssupport toolssystem-level barrierstooltreatment strategy
项目摘要
ABSTRACT
Our multidisciplinary, multi-country team of implementation science experts propose to adapt, implement, and
evaluate the “Integrating HIV and hEART health in South Africa” (iHeart-SA) program that incorporates
hypertension (HTN) and diabetes (DM) screening and treatment for people living with HIV (PLWH). SA is the
epicenter of the HIV pandemic worldwide with over 7 million PLWH, of whom ~5 million are treated with anti-
retroviral therapies (ART). ART rollout has two relevant repercussions: first, PLWH now have approximately
twice the risk of developing HTN, DM, and cardiovascular disease (CVD); and second, the success of ART
programs creates a corresponding mandate to deliver integrated, high-quality, sustainable treatment strategies
to detect, treat, and control HTN and DM in HIV care. There are patient-, provider-, and system-level barriers to
achieving these goals; but, there are also evidence-based interventions to address them, and we have
extensive experience applying these to transform care for CVD co-morbidities in South Africa and India. We
have determined the barriers to CVD care and reviewed the literature to select a package of interventions
proven successful in randomized controlled trials, including: use of non-clinician care coordinators to support
treatment documentation and quality improvement (QI); incorporation of home monitoring to enhance self-
management; decision-support tools to facilitate treatment initiation and modifications; and monthly audit /
feedback meetings to support continuous QI. We will use the EPIS framework and partner with government,
academic, facility, and community stakeholders to guide the project by: Exploring (engaging stakeholders in
human-centered design to co-adapt the intervention package to align with local capacity, opportunities, and
motivations, Aim UG1); Preparing (strengthening capacity in implementation science, Aim UG2);
Implementing and evaluating the intervention package via a stepped wedge cluster trial and assessing both
implementation (e.g., reach, adoption, fidelity) and effectiveness (e.g., controlled blood pressure [primary
outcome] among PLWH and HTN), Aim UH1; measuring Sustainability and costs after 24 months (where 12
months were spent transferring delivery from study to local staff (Aim UH2); and developing a strategy to scale
up to rural clinics and nationally (Aim UH3). The overall goal of this project is to employ rigorous empirical
methods to develop and test care innovations that expand the scope of HIV care in a sustainable, scalable,
and impactful way. We will employ an achievable milestone plan to deliver high quality outputs, including:
continued stakeholder relationships and co-ownership of the study over the project period; completion of three
PhDs in implementation science; and disseminating findings via high-impact publications and presentations.
We will also participate in NHLBI’s collaborative multi-institution network designed to strengthen research
methods and impacts across all sites, and to advance training of the next generation of scientific leaders.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Mohammed Kumail Ali其他文献
Mohammed Kumail Ali的其他文献
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{{ truncateString('Mohammed Kumail Ali', 18)}}的其他基金
Training on ImplemenTAtioN and team Science for NCD Control (TITANS) program
非传染性疾病控制 (TITANS) 计划的实施和团队科学培训
- 批准号:
10665456 - 财政年份:2023
- 资助金额:
$ 83.55万 - 项目类别:
Enhanced BReast and cErvical cAncer screening in Kenya THROUGH implementation science research and training (The BREAKTHROUGH Center)
通过实施科学研究和培训,肯尼亚加强了乳腺癌和宫颈癌筛查(突破中心)
- 批准号:
10738131 - 财政年份:2023
- 资助金额:
$ 83.55万 - 项目类别:
Can Medicaid Managed Care mitigate race/ethnic health disparities in diabetes?
医疗补助管理式医疗能否减轻糖尿病中的种族/民族健康差异?
- 批准号:
10528738 - 财政年份:2022
- 资助金额:
$ 83.55万 - 项目类别:
Can Medicaid Managed Care mitigate race/ethnic health disparities in diabetes?
医疗补助管理式医疗能否减轻糖尿病中的种族/民族健康差异?
- 批准号:
10709582 - 财政年份:2022
- 资助金额:
$ 83.55万 - 项目类别:
Integrating HIV and hEART health in South Africa (iHeart-SA)
在南非整合艾滋病毒和心脏抗逆转录病毒治疗 (iHeart-SA)
- 批准号:
10841100 - 财政年份:2020
- 资助金额:
$ 83.55万 - 项目类别:
Integrating HIV and hEART health in South Africa (iHeart-SA)
在南非整合艾滋病毒和心脏抗逆转录病毒治疗 (iHeart-SA)
- 批准号:
10705125 - 财政年份:2020
- 资助金额:
$ 83.55万 - 项目类别:
Integrating HIV and hEART health in South Africa (iHeart-SA)
在南非整合艾滋病毒和心脏抗逆转录病毒治疗 (iHeart-SA)
- 批准号:
10267701 - 财政年份:2020
- 资助金额:
$ 83.55万 - 项目类别:
COllaborative research, implementation, And LEadership training to addresS chronic Conditions across the lifecoursE (COALESCE)
协作研究、实施和领导力培训,以解决整个生命周期的慢性病(COALESCE)
- 批准号:
10210320 - 财政年份:2019
- 资助金额:
$ 83.55万 - 项目类别:
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