Enhanced BReast and cErvical cAncer screening in Kenya THROUGH implementation science research and training (The BREAKTHROUGH Center)

通过实施科学研究和培训，肯尼亚加强了乳腺癌和宫颈癌筛查（突破中心）

• 批准号: 10738131
• 负责人: Mohammed Kumail Ali
• 金额: $ 96.17万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-19 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10738131
• 关键词: Acceleration; Address; Adoption; Advanced Malignant Neoplasm; Africa; Africa South of the Sahara; Awareness; Behavioral; Biometry; Breast Cancer Detection; Breast Cancer Early Detection; Breast Cancer Treatment; Canada; Cancer Burden; Cancer Control; Caring; Cervical Cancer Screening; Cessation of life; Clinic; Clinical; Communities; Complex; Country; Data; Development; Diagnosis; Disease; Early Diagnosis; Early identification; Early treatment; Economics; Effectiveness; Epidemiology; Equity; Faculty; Family; Future; Gender; Government; Guidelines; HIV; Health; Health Services Accessibility; Health system; Hospitals; Human Papillomavirus; Incidence; Individual; Inequity; Infection; Information Technology; Infrastructure; Institution; International; Intervention; Kenya; Knowledge; Leadership; Life Style; Link; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Maps; Mentors; Mentorship; Methods; Morbidity - disease rate; Obesity; Oncology; Patients; Pattern; Personal Satisfaction; Policies; Policy Maker; Preventive screening; Primary Care; Process; Provider; Recommendation; Research; Research Personnel; Research Project Grants; Resources; Rest; Scientist; Screening for cancer; Smoking; Students; System; Talents; Technology; Testing; Time; Training; Translations; Universities; Variant; Washington; Woman; Women' s Health; Work; advanced disease; base; cancer diagnosis; cancer type; care coordination; career; community engagement; cost; design; disability; effectiveness testing; effectiveness trial; evidence base; experience; feasibility testing; implementation research; implementation science; implementation strategy; improved; knowledge translation; low and middle-income countries; mHealth; malignant breast neoplasm; mortality; next generation; patient oriented; premalignant; prevent; programs; screening; social; tumor progression; uptake; user-friendly

CENTER OVERALL: PROGRAM SUMMARY / ABSTRACT While considerable evidence is available for screening and early treatment of breast and cervical cancers, huge gaps remain in equitable and sustainable translation of this knowledge into practice and policy, especially in sub-Saharan Africa. In Kenya, gaps in screening and linkage to treatment result in late-stage presentation of breast and cervical cancers, profound preventable morbidity and mortality, and disproportionate hindrance to women’s development. To close these gaps, the Enhanced BReast and cErvical cAncer screening in Kenya THROUGH implementation science research and training (BREAKTHROUGH) Center coalesces trans- disciplinary expertise at Kenyatta National Hospital (KNH), Emory University, University of Washington, and Queen’s University. BREAKTHROUGH will include an Administrative and Engagement Core that engages community, clinical, and government stakeholders and scientific partners, and seamlessly coordinates [Overall Aim 1] our interrelated Research Capacity Building Core and two Research Projects. Our multi-institutional, collaborative partners bring considerable breadth and depth of implementation science and oncology expertise, a substantial research base, matched resource commitments (>$125,000 in contributions), international gravitas, and >10 years of working together. To grow implementation science in women’s cancer control and conduct impactful research, BREAKTHROUGH has a training framework that engages investigators across the career spectrum (faculty, fellows, students) to sustainably strengthen capacity by supporting trainees to become mentors [Overall Aim 2]. We provide didactic training; engagement in Research Projects; and access to stakeholders, technologies, networking, and enrichment activities. BREAKTHROUGH’s projects will map and co-design (with stakeholders) strategies that overcome barriers to women’s cancer control. We then test feasibility, implementation, effectiveness, and sustainment of context-specific, theoretically-informed strategies for overcoming complex barriers to adoption and integration of breast and cervical cancer screening and referral linkages in primary care [center theme; Overall Aim 3]. We also utilize these projects as training platforms to strengthen local capacity and research administration for implementation science at KNH. Project 1 is entitled “accelerating aDoption of pAtient-centereD cervicAl cancer screening and treatment LINKage in Kenya” (DADA LINK) and Project 2 is entitled “a Multi-level strATegy for InTegrating Information technologY and mobile health to strengthen linkAges to breast caNcer screeninG and early detection among women Utilizing primary care in Kenya (MATITI YANGU). The Center, Cores, and Projects will produce actionable, mixed methods, user-friendly evidence and bidirectionally engage with key stakeholders as advisors and disseminators, maximizing reach, uptake, and sustainability. BREAKTHROUGH is well-integrated across Cores and Projects and embodies an ethos of promoting equity in our institutions, research, and our impacts.

研究中心总体：研究总结/摘要 虽然有相当多的证据可用于乳腺癌和宫颈癌的筛查和早期治疗， 在公平和可持续地将这些知识转化为实践和政策方面， 于撒哈拉以南非洲的在肯尼亚，由于在筛查和与治疗联系方面存在差距， 乳腺癌和宫颈癌、可预防的发病率和死亡率居高不下， 妇女的发展。为了缩小这些差距，肯尼亚的增强型BReast和cErcancAncer筛查 通过实施科学研究和培训（突破）中心合并跨- 肯雅塔国立医院（KNH），埃默里大学，华盛顿大学的学科专业知识， 皇后大学突破将包括一个管理和参与核心， 社区、临床和政府利益相关者以及科学合作伙伴，并无缝协调[总体 目标1]我们相互关联的研究能力建设核心和两个研究项目。我们的多机构， 合作伙伴带来了相当广泛和深入的实施科学和肿瘤学专业知识， 一个坚实的研究基础，匹配的资源承诺（> 125，000美元的捐款），国际 #21453;，以及10年的合作。在妇女癌症控制中发展实施科学， 进行有影响力的研究，突破有一个培训框架，从事调查人员在整个 职业范围（教师、研究员、学生），通过支持受训人员 成为导师[总体目标2]。我们提供教学培训;参与研究项目;和访问 利益相关者、技术、网络和丰富活动。突破的项目将映射 （与利益攸关方）共同设计克服妇女癌症控制障碍的战略。然后我们测试 可行性，实施，有效性，和具体情况下，理论上知情的战略的可持续性 克服采用和整合乳腺癌和宫颈癌筛查的复杂障碍， 初级保健中的转诊联系[中心主题;总体目标3]。我们还利用这些项目作为培训 平台，以加强当地的能力和研究管理，在KNH实施科学。项目 1题为“加速以患者为中心的宫颈癌筛查和治疗联系的选择， 项目2题为“信息技术一体化的多层次战略 和移动的保健，以加强年龄与乳腺癌筛查和妇女早期发现的联系 在肯尼亚利用初级保健（MATITI YANGU）。该中心，核心和项目将产生可操作的， 混合方法，用户友好的证据和双向参与与关键利益相关者作为顾问， 传播者，最大限度地扩大覆盖面，吸收和可持续性。BREAKTHROUGH在各个领域都有很好的集成 核心和项目，体现了促进我们的机构，研究和我们的影响公平的精神。