Enhanced BReast and cErvical cAncer screening in Kenya THROUGH implementation science research and training (The BREAKTHROUGH Center)
通过实施科学研究和培训,肯尼亚加强了乳腺癌和宫颈癌筛查(突破中心)
基本信息
- 批准号:10738131
- 负责人:
- 金额:$ 96.17万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-19 至 2028-08-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAddressAdoptionAdvanced Malignant NeoplasmAfricaAfrica South of the SaharaAwarenessBehavioralBiometryBreast Cancer DetectionBreast Cancer Early DetectionBreast Cancer TreatmentCanadaCancer BurdenCancer ControlCaringCervical Cancer ScreeningCessation of lifeClinicClinicalCommunitiesComplexCountryDataDevelopmentDiagnosisDiseaseEarly DiagnosisEarly identificationEarly treatmentEconomicsEffectivenessEpidemiologyEquityFacultyFamilyFutureGenderGovernmentGuidelinesHIVHealthHealth Services AccessibilityHealth systemHospitalsHuman PapillomavirusIncidenceIndividualInequityInfectionInformation TechnologyInfrastructureInstitutionInternationalInterventionKenyaKnowledgeLeadershipLife StyleLinkMalignant NeoplasmsMalignant neoplasm of cervix uteriMapsMentorsMentorshipMethodsMorbidity - disease rateObesityOncologyPatientsPatternPersonal SatisfactionPoliciesPolicy MakerPreventive screeningPrimary CareProcessProviderRecommendationResearchResearch PersonnelResearch Project GrantsResourcesRestScientistScreening for cancerSmokingStudentsSystemTalentsTechnologyTestingTimeTrainingTranslationsUniversitiesVariantWashingtonWomanWomen&aposs HealthWorkadvanced diseasebasecancer diagnosiscancer typecare coordinationcareercommunity engagementcostdesigndisabilityeffectiveness testingeffectiveness trialevidence baseexperiencefeasibility testingimplementation researchimplementation scienceimplementation strategyimprovedknowledge translationlow and middle-income countriesmHealthmalignant breast neoplasmmortalitynext generationpatient orientedpremalignantpreventprogramsscreeningsocialtumor progressionuptakeuser-friendly
项目摘要
CENTER OVERALL: PROGRAM SUMMARY / ABSTRACT
While considerable evidence is available for screening and early treatment of breast and cervical cancers,
huge gaps remain in equitable and sustainable translation of this knowledge into practice and policy, especially
in sub-Saharan Africa. In Kenya, gaps in screening and linkage to treatment result in late-stage presentation of
breast and cervical cancers, profound preventable morbidity and mortality, and disproportionate hindrance to
women’s development. To close these gaps, the Enhanced BReast and cErvical cAncer screening in Kenya
THROUGH implementation science research and training (BREAKTHROUGH) Center coalesces trans-
disciplinary expertise at Kenyatta National Hospital (KNH), Emory University, University of Washington, and
Queen’s University. BREAKTHROUGH will include an Administrative and Engagement Core that engages
community, clinical, and government stakeholders and scientific partners, and seamlessly coordinates [Overall
Aim 1] our interrelated Research Capacity Building Core and two Research Projects. Our multi-institutional,
collaborative partners bring considerable breadth and depth of implementation science and oncology expertise,
a substantial research base, matched resource commitments (>$125,000 in contributions), international
gravitas, and >10 years of working together. To grow implementation science in women’s cancer control and
conduct impactful research, BREAKTHROUGH has a training framework that engages investigators across the
career spectrum (faculty, fellows, students) to sustainably strengthen capacity by supporting trainees to
become mentors [Overall Aim 2]. We provide didactic training; engagement in Research Projects; and access
to stakeholders, technologies, networking, and enrichment activities. BREAKTHROUGH’s projects will map
and co-design (with stakeholders) strategies that overcome barriers to women’s cancer control. We then test
feasibility, implementation, effectiveness, and sustainment of context-specific, theoretically-informed strategies
for overcoming complex barriers to adoption and integration of breast and cervical cancer screening and
referral linkages in primary care [center theme; Overall Aim 3]. We also utilize these projects as training
platforms to strengthen local capacity and research administration for implementation science at KNH. Project
1 is entitled “accelerating aDoption of pAtient-centereD cervicAl cancer screening and treatment LINKage in
Kenya” (DADA LINK) and Project 2 is entitled “a Multi-level strATegy for InTegrating Information technologY
and mobile health to strengthen linkAges to breast caNcer screeninG and early detection among women
Utilizing primary care in Kenya (MATITI YANGU). The Center, Cores, and Projects will produce actionable,
mixed methods, user-friendly evidence and bidirectionally engage with key stakeholders as advisors and
disseminators, maximizing reach, uptake, and sustainability. BREAKTHROUGH is well-integrated across
Cores and Projects and embodies an ethos of promoting equity in our institutions, research, and our impacts.
总体中心:计划摘要/摘要
虽然有相当多的证据可以用于乳腺癌和宫颈癌的筛查和早期治疗,
在公平和可持续地将这一知识转化为实践和政策方面仍然存在巨大差距,特别是
在撒哈拉以南非洲。在肯尼亚,筛查和与治疗的联系方面的差距导致晚期
乳腺癌和宫颈癌,严重的可预防的发病率和死亡率,以及对
妇女发展。为了缩小这些差距,肯尼亚加强了乳腺癌和宫颈癌筛查
通过实施科学研究和培训(突破)中心将跨
肯雅塔国家医院(KNH)、埃默里大学、华盛顿大学和
皇后大学。突破将包括管理和接洽核心,
社区、临床和政府利益相关者和科学合作伙伴,并无缝协调[总体
目的1]我们相关的研究能力建设核心和两个研究项目。我们的多机构,
合作伙伴带来了实施科学和肿瘤学专业知识的相当大的广度和深度,
雄厚的研究基础,匹配的资源承诺(捐款12.5万美元),国际
庄严,和>;10年的合作。在妇女癌症控制和预防中发展实施科学
进行有影响力的研究,突破性有一个培训框架,让全世界的调查人员参与进来
职业范围(教师、研究员、学生),通过支持受训人员可持续地增强能力
成为导师[总体目标2]。我们提供教学培训;参与研究项目;以及访问
对利益相关者、技术、网络和丰富活动。突破性的项目将绘制地图
以及(与利益相关者)共同设计克服女性癌症控制障碍的战略。然后我们测试
针对具体情况、从理论上了解情况的战略的可行性、实施、有效性和维持
克服采用和整合乳腺癌和宫颈癌筛查和整合的复杂障碍
初级保健中的转诊联系[中心主题;总体目标3]。我们还利用这些项目作为培训
加强KNH实施科学的地方能力和研究管理的平台。项目
1题为《加快采用以患者为中心的宫颈癌筛查和治疗联动机制》
肯尼亚“(达达链接)和项目2题为”整合信息技术的多层次战略“
和流动保健,以加强与乳腺癌筛查和妇女早期发现的联系
在肯尼亚利用初级保健(MATITI Yangu)。该中心、核心和项目将产生可操作的、
混合方法、用户友好的证据并作为顾问和关键利益相关者双向接触
传播者,最大限度地扩大影响、吸收和可持续性。突破性进展与
核心和项目,体现了在我们的机构、研究和影响中促进公平的精神。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Mohammed Kumail Ali其他文献
Mohammed Kumail Ali的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Mohammed Kumail Ali', 18)}}的其他基金
Training on ImplemenTAtioN and team Science for NCD Control (TITANS) program
非传染性疾病控制 (TITANS) 计划的实施和团队科学培训
- 批准号:
10665456 - 财政年份:2023
- 资助金额:
$ 96.17万 - 项目类别:
Can Medicaid Managed Care mitigate race/ethnic health disparities in diabetes?
医疗补助管理式医疗能否减轻糖尿病中的种族/民族健康差异?
- 批准号:
10528738 - 财政年份:2022
- 资助金额:
$ 96.17万 - 项目类别:
Can Medicaid Managed Care mitigate race/ethnic health disparities in diabetes?
医疗补助管理式医疗能否减轻糖尿病中的种族/民族健康差异?
- 批准号:
10709582 - 财政年份:2022
- 资助金额:
$ 96.17万 - 项目类别:
Integrating HIV and hEART health in South Africa (iHeart-SA)
在南非整合艾滋病毒和心脏抗逆转录病毒治疗 (iHeart-SA)
- 批准号:
10508822 - 财政年份:2020
- 资助金额:
$ 96.17万 - 项目类别:
Integrating HIV and hEART health in South Africa (iHeart-SA)
在南非整合艾滋病毒和心脏抗逆转录病毒治疗 (iHeart-SA)
- 批准号:
10841100 - 财政年份:2020
- 资助金额:
$ 96.17万 - 项目类别:
Integrating HIV and hEART health in South Africa (iHeart-SA)
在南非整合艾滋病毒和心脏抗逆转录病毒治疗 (iHeart-SA)
- 批准号:
10705125 - 财政年份:2020
- 资助金额:
$ 96.17万 - 项目类别:
Integrating HIV and hEART health in South Africa (iHeart-SA)
在南非整合艾滋病毒和心脏抗逆转录病毒治疗 (iHeart-SA)
- 批准号:
10267701 - 财政年份:2020
- 资助金额:
$ 96.17万 - 项目类别:
COllaborative research, implementation, And LEadership training to addresS chronic Conditions across the lifecoursE (COALESCE)
协作研究、实施和领导力培训,以解决整个生命周期的慢性病(COALESCE)
- 批准号:
10210320 - 财政年份:2019
- 资助金额:
$ 96.17万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 96.17万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 96.17万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 96.17万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 96.17万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 96.17万 - 项目类别:
Standard Grant
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 96.17万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 96.17万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 96.17万 - 项目类别:
EU-Funded
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 96.17万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 96.17万 - 项目类别:
Research Grant