COllaborative research, implementation, And LEadership training to addresS chronic Conditions across the lifecoursE (COALESCE)

节目摘要/摘要 慢性心脏代谢(糖尿病、心血管疾病)和神经精神疾病(认知和 精神健康障碍)在低收入和中等收入国家迅速增长的公共卫生问题 (LMIC)。印度和埃塞俄比亚等低收入国家的慢性病发病率正在上升，同时仍在与 营养不良和环境污染的残余负担。LMIC对慢性疾病的反应是 受限于有限的研究能力。我们建议解决研究和实施方面的不足 印度和埃塞俄比亚的慢性病治疗能力。来自埃默里大学的团队(阿里，项目总监 [PD])、印度慢性病控制中心(Prabhakaran，co-PD)和亚的斯亚贝巴大学， 埃塞俄比亚(Mariam，共同PD)共同设计了“合作研究、实施和领导力培训” 以解决整个生命过程中的慢性病“(COALESSE)计划。我们从前两次抽签 成功的培训计划和新增的关键创新。向可持续的国内研究迈进 培训，我们将为12名中期研究人员提供导师培训，以发展国内能力，以获得更多 对年轻研究人员的有效指导。此外，之前的D43计划校友将参加 指导培训，并担任联合培训学员的研究导师。这种方法利用了以前的 投资并为以前的学员提供职业发展和支持，担任新的导师角色。我们会 然后每年招聘和培训四批六名博士后实习生(印度和埃塞俄比亚各三名) (总计n=24)，为期18个月的研究金。该奖学金包括在埃默里大学完成的两个月 课程作业，参与美国研究文化，并开发项目概念；在接下来的16个月里，学员 将在本国和美国导师的指导下在本国完成项目。我们将推动 对整个生命过程中慢性疾病的综合观点，并将受训者与资源(例如， 队列研究、附属中心)，具有广泛的内容和方法专长。为了加强我们的 合作伙伴LMIC机构从内部，我们将提供我们成功的年度实施短期课程 能够培养组织管理技能的科学和领导力。要加快翻译速度和 将证据落实到实践中，我们将开设实施科学与领导力课程 处于预防和控制第一线的公共卫生、政府和临床从业者(n=80) 计划和政策的执行。联合参与的研究人员和实践者将直接将这些 通常孤立利益相关者并促进协作。我们将利用埃默里大学的悠久历史 在印度和埃塞俄比亚建立伙伴关系，为南南合作提供机会。《联合》 该计划旨在通过提供津贴、当地指导、 将受训人员项目嵌入现有平台，并激发生产力文化。该计划雄心勃勃 促进以地方为导向的研究，以确定慢性病的优先事项、做法、计划和政策。

PROGRAM SUMMARY / ABSTRACT Chronic cardio-metabolic (diabetes, cardiovascular diseases) and neuropsychiatric conditions (cognitive and mental health disorders) are rapidly growing public health problems in low- and middle-income countries (LMIC). LMICs such as India and Ethiopia are experiencing rising chronic diseases while still contending with residual burdens of under-nutrition and environmental pollution. Responses to chronic conditions in LMICs are constrained by limited research capacity. We propose to address shortages in research and implementation capacity for chronic conditions in India and Ethiopia. Teams from Emory University (Ali, Program Director [PD]), the Center for Chronic Disease Control, India (Prabhakaran, co-PD), and Addis Ababa University, Ethiopia (Mariam, co-PD) co-designed the “COllaborative Research, Implementation, And LEadership Training to AddresS Chronic Conditions across the Life CoursE” (COALESCE) program. We draw from two previous successful training programs and added key innovations. To progress towards sustainable in-country research training, we will provide mentor training to 12 mid-stage researchers to develop in-country capacity for more effective mentoring of young researchers. Moreover, prior D43 program alumni will be participants of the mentor training and serve as research mentors for COALESCE trainees. This approach capitalizes on previous investments and provides career advancement and support for previous trainees in new mentor roles. We will then recruit and train four cohorts of six post-doctoral trainees (three each from India and Ethiopia) annually (total n=24) in an 18-month fellowship. The fellowship includes two months at Emory University to complete coursework, engage in US research culture, and develop project concepts; over the next 16 months, trainees will complete projects in their home country with guidance from in-country and US mentors. We will promote an integrated perspective of chronic conditions across the life course, and connect trainees with resources (e.g., cohort studies, affiliated centers) with wide-ranging content and methodological expertise. To strengthen our partner LMIC institutions from within, we will deliver our successful annual short-course on implementation science and leadership that can cultivate organizational management skills. To accelerate translation and implementation of evidence into practice, we will open the implementation science and leadership course to public health, government, and clinical practitioners (n=80) that are on the frontline of prevention and control program and policy implementation. Jointly engaging researchers and practitioners will directly connect these usually siloed stakeholders and promote collaboration. We will leverage Emory University's longstanding partnerships in India and Ethiopia and open opportunities for South-South collaboration. The COALESCE program is designed to promote high in-country retention of trainees by providing stipends, local mentorship, embedding trainee projects in existing platforms, and motivating a culture of productivity. The program aspires to facilitate locally-driven research to shape chronic disease priorities, practices, programs, and policies.