An Ecosystem of Technology and Protocols for Adaptive Neuromodulation Research in Humans

人类自适应神经调节研究的技术和协议生态系统

• 批准号: 10516471
• 负责人: Peter Brunner
• 金额: $ 117.59万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-21 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10516471
• 关键词: Achievement; Address; Adoption; Affect; Animals; Area; Base of the Brain; Basic Science; Behavioral; Brain; Cardiovascular Diseases; Clinical; Clinical Protocols; Clinical Research; Communication; Communities; Computer software; Conceptions; Data; Development; Devices; Diabetes Mellitus; Diagnosis; Disabled Persons; Documentation; Ecosystem; Educational workshop; Engineering; Feedback; Goals; Health Care Costs; Human; Implant; Investigation; Lead; Malignant Neoplasms; Mental Depression; Mental disorders; Movement Disorders; Mus; Nervous system structure; Operative Surgical Procedures; Pain; Performance; Persons; Physiology; Protocols documentation; Research; Resistance; Scientist; Signal Transduction; Site; Spinal cord injury; Stroke; Structure; Support System; System; Technology; Testing; Time; Training; United States; Work; base; canine model; clinical application; communication aid; experimental study; implantation; improved; nervous system disorder; neuroregulation; neurotechnology; nonhuman primate; novel; novel therapeutics; open source; relating to nervous system; research clinical testing; success; symptomatic improvement; theories

Project Summary/Abstract Neurological and psychiatric disorders affect millions of people in the United States and worldwide, and produce a third of all health care costs. Recent research has produced encouraging evidence that adaptive neuromodulation can induce nervous system plasticity that produces long-lasting improvements in certain neurological disorders such as stroke. At the same time, it is becoming increasingly clear that the technologies that support these demonstrations remain painfully inadequate and inaccessible for both research and clinical application: current non-invasive technologies are typically imprecise; and current invasive technologies, which are more precise, are currently only available with serious restrictions for human use. Moreover, all of the few existing neuromodulation platforms for human use require substantial expertise in diverse areas of engineering, physiology, and regulatory domains that is not available to most groups. This lack of availability of sufficiently capable and readily useable neuromodulation technologies greatly impedes the development, application, and optimization of new adaptive protocols for improving symptoms of devastating neurological and psychiatric disorders. The purpose of the project proposed here is to address this critical issue by developing, validating, and widely sharing with the community an easy-to-use adaptive neuromodulation ecosystem (comprised of technology and protocols) that is optimized for the needs of invasive basic and clinical research. We will validate this ecosystem in a canine model, and disseminate it with appropriate documentation to other scientists and clinicians through three project-related test sites and three workshops. In accord with this objective, we will: 1. Develop a general-purpose hardware/software neuromodulation platform for invasive neuromodulation research 2. Develop and validate an ecosystem for adaptive neuromodulation research and clinical application 3. Disseminate this ecosystem of technologies and protocols Achieving these three aims will create, validate, and disseminate the first comprehensive ecosystem that facilitates the conception, development, and clinical application of invasive adaptive neuromodulation protocols. We expect that the availability of this ecosystem will greatly increase activities in basic and clinical neuromodulation research that will lead to new understanding of the neural underpinnings of normal and abnormal function and will thereby accelerate the development of novel adaptive neuromodulation protocols to improve treatment for many devastating neurological disorders.

项目概要/摘要 神经和精神疾病影响着美国和全世界数百万人，并产生 占所有医疗保健费用的三分之一。最近的研究提供了令人鼓舞的证据，表明适应性神经调节 可以诱导神经系统可塑性，从而对某些神经系统疾病产生持久的改善 例如中风。与此同时，越来越明显的是，支持这些的技术 对于研究和临床应用来说，演示仍然严重不足且无法实现：当前 非侵入性技术通常不精确；目前更精确的侵入性技术是 目前仅在严格限制下可供人类使用。此外，所有现有的少数神经调节 供人类使用的平台需要工程、生理学和监管等不同领域的丰富专业知识 大多数组无法使用的域。缺乏足够功能且易于使用的 神经调节技术极大地阻碍了新的自适应技术的开发、应用和优化 改善破坏性神经和精神疾病症状的方案。 这里提出的项目的目的是通过开发、验证和广泛地解决这个关键问题 与社区分享一个易于使用的自适应神经调节生态系统（由技术和 协议），针对侵入性基础和临床研究的需求进行了优化。我们将在以下时间验证这个生态系统 犬模型，并通过三个途径将其与适当的文件一起传播给其他科学家和临床医生 项目相关的测试场地和三个研讨会。根据这一目标，我们将： 1. 开发用于侵入性神经调节研究的通用硬件/软件神经调节平台 2. 开发和验证自适应神经调节研究和临床应用的生态系统 3. 传播这个技术和协议生态系统 实现这三个目标将创建、验证和传播第一个综合生态系统 促进侵入性适应性神经调节方案的构思、开发和临床应用。 我们预计该生态系统的可用性将大大增加基础和临床神经调节的活动 研究将导致对正常和异常功能的神经基础有新的认识，并将 从而加速新型适应性神经调节方案的开发，以改善许多患者的治疗 毁灭性的神经系统疾病。