TBEL Administrative Core

项目摘要/摘要： 管理核心的使命是确保个人研究项目和研究核心 与超越各自部分的协同作用相结合，为TBEL计划创造更多力量做出贡献 个人中心，与NCI和癌症研究社区整合。行政核心 为这项任务提供必要的基础设施。核心将监督一个多组成部分的研究计划 包括两个基础科学和一个翻译项目，并利用不同的数据收集和分析 医疗模式。为了促进协同作用，核心将成为内部活动的主要联系人，包括后勤和 组织活动、科学和行政活动以及协作项目征集、审查、 资金和评估。将我们建议的中心嵌入TBEL计划和更广泛的癌症研究 社区，这个核心也将是与NCI、其他TBEL中心、 协调和数据管理中心(CDMC)和外部癌症研究人员。核心领导层， De Marzo博士和Yegnasubramanian博士19年来一直是积极的合作者，他们共同资助了NCI 孢子奖助金和NCI MCL奖助金在过去的6年里都是50个同行评议初选的共同作者 出版物和16篇评论文章。De Marzo博士和Yegnasubramanian博士也嵌入了内部和 支持其作用的外部研究网络。此外，他们还共同指导了几名研究生 和博士后研究员，经常在他们的研究生同事的论文委员会任职。他们已经奏效了 在过去的10年里，在前列腺癌的分子病理学和基因组学方面进行了广泛的合作，包括 领导JHU NCI MCL-U01项目的所有RNAseq和全基因组测序工作，包括 临床前地图集飞行员。此外，他们还在前列腺癌的分子和细胞生物学方面进行了广泛的合作。 在高级别PIN病变和PIA中共同发现GSTP1部分DNA甲基化的前驱病变；一个发现 与当前的提案直接相关。最后，他们与比伯里奇博士在 前列腺癌和侵袭性前列腺癌小鼠模型的分子病理学和基因组学研究 与惰性前列腺癌的对比，以及与Pienta博士在所有管理方面和肿瘤微环境的对比 与NCI MCL-U01计划相关的研究。

Project Summary/Abstract: The mission of the Administration Core is to ensure that the individual Research Projects, and the Research Core combine with synergy beyond their individual parts, to contribute to the TBEL Program creating strength beyond the individual Centers, to integrate with the NCI and the cancer research community. The Administrative Core provides the infrastructure essential for this mission. The Core will supervise a multi-component research program encompassing two basic science and one translational projects, and utilizing diverse data collection and analysis modalities. To foster synergy, the Core will be the primary contact for internal activities including logistical and organizational activities, scientific and administrative activities, and collaborative project solicitation, review, funding, and evaluation. To embed our proposed Center within the TBEL Program and the broader cancer research community, this Core will also be the primary contact for external interactions with the NCI, other TBEL Centers, the Coordinating and Data Management Center (CDMC), and external cancer researchers. The Core Leaders, Drs. De Marzo and Yegnasubramanian, have been active collaborators for 19 years, have joint funding on the NCI SPORE grant as well as the NCI MCL grant for the past 6 years and are co-authors on 50 peer-reviewed primary publications and 16 review articles. Drs. De Marzo and Yegnasubramanian are also embedded in internal and external research networks that support their roles. In addition, they have co-mentored several graduate students and post-doctoral fellows, often serving on their fellow graduate student's thesis committees. They have worked together extensively on the molecular pathology and genomics of prostate cancer over the last 10 years, including leading all the RNAseq and whole genomic sequencing efforts for JHU the NCI MCL-U01 projects, including the pre-clinical atlas pilot. Also, together they have worked extensively on the molecular and cellular biology of prostate precursor lesions , together finding partial DNA methylation of GSTP1 in high grade PIN lesions and PIA; a finding directly relevant to the current proposal. Finally, they have worked together extensively, with Dr. Bieberich, on the molecular pathology and genomics of mouse models of prostatic inflammation driven neoplasia and of aggressive versus indolent prostate cancer, and with Dr. Pienta in all administrative aspects and tumor microenvironment studies related to the NCI MCL-U01 Program.