TBEL Administrative Core

TBEL 行政核心

• 批准号: 10698120
• 负责人: ANGELO Michael DE MARZO
• 金额: $ 38.1万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10698120
• 关键词: Address; Atlases; Basic Science; Collaborations; Communication; Communities; DNA Methylation; Data Analyses; Data Collection; Data Coordinating Center; Development; Discipline; Electronic Mail; Evaluation; Evolution; Fostering; Funding; GSTP1 gene; Genomics; Grant; Human Resources; Individual; Indolent; Inflammation; Inflammatory; Infrastructure; Institution; Joints; Knowledge; Leadership; Lesion; Malignant Neoplasms; Malignant neoplasm of prostate; Mentors; Mission; Modality; Molecular and Cellular Biology; Neoplasms; Peer Review; Postdoctoral Fellow; Procedures; Progress Reports; Prostate; Prostatic; Publications; Research; Research Activity; Research Personnel; Research Project Grants; Role; Site Visit; Students; Summary Reports; Teleconferences; Telephone; Work; anticancer research; carcinogenesis; diverse data; graduate student; interdisciplinary approach; meetings; molecular pathology; mouse model; pre-clinical; programs; support network; synergism; transcriptome sequencing; translational approach; tumor microenvironment; virtual; working group

Project Summary/Abstract: The mission of the Administration Core is to ensure that the individual Research Projects, and the Research Core combine with synergy beyond their individual parts, to contribute to the TBEL Program creating strength beyond the individual Centers, to integrate with the NCI and the cancer research community. The Administrative Core provides the infrastructure essential for this mission. The Core will supervise a multi-component research program encompassing two basic science and one translational projects, and utilizing diverse data collection and analysis modalities. To foster synergy, the Core will be the primary contact for internal activities including logistical and organizational activities, scientific and administrative activities, and collaborative project solicitation, review, funding, and evaluation. To embed our proposed Center within the TBEL Program and the broader cancer research community, this Core will also be the primary contact for external interactions with the NCI, other TBEL Centers, the Coordinating and Data Management Center (CDMC), and external cancer researchers. The Core Leaders, Drs. De Marzo and Yegnasubramanian, have been active collaborators for 19 years, have joint funding on the NCI SPORE grant as well as the NCI MCL grant for the past 6 years and are co-authors on 50 peer-reviewed primary publications and 16 review articles. Drs. De Marzo and Yegnasubramanian are also embedded in internal and external research networks that support their roles. In addition, they have co-mentored several graduate students and post-doctoral fellows, often serving on their fellow graduate student's thesis committees. They have worked together extensively on the molecular pathology and genomics of prostate cancer over the last 10 years, including leading all the RNAseq and whole genomic sequencing efforts for JHU the NCI MCL-U01 projects, including the pre-clinical atlas pilot. Also, together they have worked extensively on the molecular and cellular biology of prostate precursor lesions , together finding partial DNA methylation of GSTP1 in high grade PIN lesions and PIA; a finding directly relevant to the current proposal. Finally, they have worked together extensively, with Dr. Bieberich, on the molecular pathology and genomics of mouse models of prostatic inflammation driven neoplasia and of aggressive versus indolent prostate cancer, and with Dr. Pienta in all administrative aspects and tumor microenvironment studies related to the NCI MCL-U01 Program.

项目摘要/摘要： 管理核心的使命是确保单个研究项目和研究核心 结合超出各个部分的协同作用，为TBEL计划做出贡献 各个中心与NCI和癌症研究界集成。行政核心 为此任务提供基础设施至关重要。核心将监督多组分研究计划 涵盖了两个基础科学和一个翻译项目，并利用多样化的数据收集和分析 方式。为了促进协同作用，核心将是内部活动的主要接触，包括后勤和 组织活动，科学和行政活动以及协作项目招标，审查， 资金和评估。将我们提出的中心嵌入TBEL计划和更广泛的癌症研究中 社区，该核心也将是与NCI，其他TBEL中心的外部互动的主要接触 协调和数据管理中心（CDMC）和外部癌症研究人员。核心领导者， 博士。 De Marzo和Yegnasubramanian一直是活跃的合作者，已有19年了，在NCI上有共同的资金 孢子补助金以及过去6年的NCI MCL赠款，是50个同行评审的主要作者 出版物和16篇评论文章。博士。 de Marzo和Yegnasubramanian也嵌入了内部和 支持其角色的外部研究网络。此外，他们还为几位研究生授予 和博士后研究员，经常在其研究生论文委员会中任职。他们工作了 在过去的十年中，包括 领导所有RNASEQ和整个基因组测序工作，用于JHU NCI MCL-U01项目，包括 临床前地图集飞行员。另外，它们共同在前列腺的分子和细胞生物学上进行了广泛的工作 前体病变，共同发现高级引脚病变和PIA中GSTP1的部分DNA甲基化；发现 与当前的建议直接相关。最后，他们与Bieberich博士进行了广泛的合作， 前列腺炎症的小鼠模型的分子病理学和基因组学驱动的肿瘤和侵略性 与懒惰的前列腺癌，以及Pienta博士在所有行政方面和肿瘤微环境中 与NCI MCL-U01计划有关的研究。