Polygenic Risk Moderates the Impact of Greenness on Cardiovascular Health among HCHS/SOL Hispanic/Latinos

多基因风险调节绿色对 HCHS/SOL 西班牙裔/拉丁裔心血管健康的影响

• 批准号: 10517620
• 负责人: Scott Charles Brown
• 金额: $ 5.7万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10517620
• 关键词: Blood Glucose; Blood Pressure; Cardiovascular Diseases; Cardiovascular system; Cholesterol; Code; Environment; Event; Exposure to; Genetic; Genetic Predisposition to Disease; Genetic Risk; Grant; Health Benefit; Hispanic Community Health Study/Study of Latinos; Hispanic Populations; Hypertension; Individual; Intervention; Latino Population; Life Style; Lipids; Logistic Regressions; Measures; Metabolic syndrome; Minority Groups; Modeling; Neighborhoods; Obesity; Outcome; Parents; Participant; Plants; Policies; Populations at Risk; Research; Risk; Risk Factors; Trees; Underserved Population; Work; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; cohort; environmental intervention; genetic variant; high risk; improved; lifestyle factors; novel; polygenic risk score; protective factors; public health relevance; secondary analysis

Polygenic Risk Moderates the Impact of Greenness on Cardiovascular Health among HCHS/SOL Hispanic/Latinos ABSTRACT Hispanics/Latinos, the largest U.S. minority group, are at relatively high risk for metabolic syndrome (MetS) which is comprised of multiple cardiovascular disease (CVD) risk factors including obesity, high blood pressure, high cholesterol, and high blood glucose. Neighborhood greenness (vegetative presence) is a novel and understudied protective factor for CVD and MetS, with emerging evidence suggesting that reductions in CVD and MetS could be achieved by optimizing environmental greenness. However, a complete understanding of “how” and “for whom” greenness provides cardiovascular health benefits has not been fully elucidated, with recent work now showing that environment and lifestyle exposure can interact with genetic susceptibility to CVD. However, no study to date has examined whether genetics moderates the relationship of environmental greenness exposure to CVD or MetS. The supplement therefore proposes to examine: (1) whether genetics moderates the relationship of greenness to cardiovascular health; (2) whether those participants with the greatest genetic risk for CVD show the greatest benefit of high greenness exposures when compared to those participants with lower genetic risk for CVD; and (3) which specific genetic variants may be contributing most to the moderating effects of genetics on cardiovascular health. Building on the parent study (R01-HL-148880), this proposed supplemental study will be the first to investigative whether a polygenic risk score (PRS) indicating a higher risk of CVD, moderates the effect of greenness on cardiovascular health. We will do so by simultaneously investigating the effects of the PRS and Greenness, and their interaction, on cardiovascular health using conditional logistic regression models as has been previously used to model the interaction of genetic risk scores and lifestyle factors on cardiovascular health in the Hispanic Community Health Study / Study of Latinos (HCHS/SOL) cohort. Therefore, the primary aim of the proposed supplement is to examine whether a polygenic risk score (PRS) indicating a higher risk of CVD, moderates the effect of greenness on cardiovascular health. We hypothesize that, when compared to participants in the lowest two tertiles of polygenic risk score (PRS) for cardiovascular outcomes, those participants in the highest tertile of PRS (i.e., showing the highest risk for CVD) will show a greater benefit of high greenness exposures on cardiovascular health, the latter measured via blood pressure, blood glucose, and lipid profile. Finally, a planned secondary analysis will seek to identify the specific genetic variants contributing to the moderating effects of PRS on the relationships of greenness to cardiovascular health. Identifying these genetic variants may help explain the mechanism underlying the greenness effect on cardiovascular health. Findings from this proposal will advance our understanding of how genetic risk for CVD may moderate the impact of greenness on cardiovascular health, which may be important for planning policy or environmental interventions (e.g., tree planting; parks) to best reduce the risk of CVD in Hispanics/Latinos.

多基因风险缓解绿色化对六六六/溶胶人群心血管健康的影响 西班牙裔/拉丁裔 摘要 拉美裔/拉丁裔是美国最大的少数群体，患代谢综合征(METS)的风险相对较高 由多种心血管疾病(CVD)危险因素组成，包括肥胖、高血压、高血压、 胆固醇和高血糖。社区绿化(植物存在)是一种新的、未被研究的概念。 心血管疾病和蛋氨酸的保护因素，新出现的证据表明，心血管疾病和蛋氨酸的减少可能 通过优化环境绿色化来实现。然而，对“如何”和“为了”的完全理解 根据最近的工作，谁的绿色提供心血管健康益处还没有完全阐明 表明环境和生活方式暴露会与心血管疾病的遗传易感性相互作用。然而，没有 到目前为止的研究已经检验了遗传学是否调节环境绿色性暴露的关系。 心脑血管疾病或大都会。因此，该副刊建议研究：(1)遗传学是否调节 绿色与心血管健康的关系；(2)那些具有最大遗传风险的参与者 与低绿度暴露的参与者相比，心血管疾病显示出高绿度暴露的最大好处 心血管疾病的遗传风险；以及(3)哪些特定的遗传变异可能对缓和效应起到最大作用 遗传学对心血管健康的影响。 在母研究(R01-HL-148880)的基础上，这项拟议的补充研究将是第一个调查性研究 表明心血管疾病风险较高的多基因风险评分(PR)是否缓和了绿色对 心血管健康。我们将通过同时调查方案和绿化的影响来做到这一点，以及 与以前一样，使用条件Logistic回归模型，它们对心血管健康的相互作用 用来模拟西班牙裔遗传风险分数和生活方式因素对心血管健康的交互作用 社区健康研究/拉丁裔研究(HCHS/SOL)队列。因此，拟议的主要目标是 补充是检查表明心血管疾病风险较高的多基因风险评分(PR)是否缓和了 绿色对心血管健康的影响。我们假设，当与最低级别的参与者相比 心血管结果的多基因风险评分(PR)的两个三位数，那些参与者在 PR(即，显示出心血管疾病的最高风险)将显示出高绿色暴露在以下方面的更大好处 心血管健康，后者通过血压、血糖和血脂水平进行测量。最后，一个有计划的 二次分析将寻求确定导致PR的缓和效应的特定遗传变异 关于绿色与心血管健康的关系。识别这些基因变异可能有助于解释 绿色化对心血管健康影响的机制。这项提案的结果将 增进我们对心血管疾病的遗传风险如何缓和绿色环境对 心血管健康，这可能对规划政策或环境干预措施很重要(例如，树 种植；公园)，以最大限度地降低拉美裔/拉丁裔的心血管疾病风险。