Greenness, Cognitive Performance and Vascular Outcomes in the NOMAS Study

NOMAS 研究中的绿色度、认知表现和血管结果

• 批准号: 10301640
• 负责人: Scott Charles Brown
• 金额: $ 226.4万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10301640
• 关键词: Affect; Age; Age-associated memory impairment; Aging; Air Pollution; Alzheimer' s Disease; Alzheimer' s disease related dementia; Antiinflammatory Effect; Behavioral; Biological; Biological Markers; Blood Pressure; Blood Vessels; Body mass index; Brain; Brain Infarction; Brain imaging; Cessation of life; Characteristics; Chronic Disease; Cognition; Cognitive; Cognitive aging; Collaborations; Complex; Crime; Data; Diabetes Mellitus; Education; Elderly; Environmental Risk Factor; Epidemiologist; Ethnic Origin; Etiology; Event; Exposure to; Geographic Locations; Health; Heart Diseases; High Prevalence; Hispanics; Hyperlipidemia; Hypertension; IL6 gene; Imagery; Impaired cognition; Income; Individual; Inflammation; Inflammatory; Interleukin-6; Life; Link; Magnetic Resonance Imaging; Measures; Mediating; Methods; Myocardial Infarction; Neighborhoods; Neurologist; Not Hispanic or Latino; Outcome; Participant; Pathway interactions; Performance; Physical activity; Pollution; Population; Prospective cohort; Psychologist; Public Health; Quality of life; Race; Research; Research Personnel; Resolution; Risk; Risk Factors; Role; Sampling; Sampling Studies; Scientist; Social support; Stroke; TNFRSF1A gene; Testing; Thick; Time; Touch sensation; Trees; White Matter Hyperintensity; adjudicate; aging population; apolipoprotein E-4; archive data; archived data; behavior measurement; cardiometabolism; cognitive disability; cognitive performance; cognitive testing; cohort; cost; data access; deprivation; ethnic minority population; experience; fasting glucose; follow-up; functional disability; imaging biomarker; interest; longitudinal design; microbiome; mild cognitive impairment; multi-ethnic; multi-racial; novel; prevent; prospective; protective effect; protective factors; racial and ethnic; resilience; sex; social; socioeconomics; stroke outcome; waist circumference; walkability

Alzheimer’s disease and related dementias (AD/ADRD), age-related cognitive decline, stroke, and heart disease are pressing public health problems with high prevalence in racial/ethnic minority older adults. Building on our strong cross-sectional findings linking greenness exposure (vegetative presence) to lower rates of chronic diseases -- including AD, cardiometabolic indicators (diabetes, hypertension, hyperlipidemia), heart disease and stroke -- we propose to investigate neighborhood greenness exposure as a novel environmental protective factor for cognitive decline and vascular outcomes (stroke, myocardial infarction [MI] and vascular death). The proposed study will be the first to investigate prospectively and longitudinally: 1) the relationship of cumulative greenness exposure to cognitive performance and vascular outcomes; 2) the mediating roles of behavioral, cardiometabolic, novel inflammatory/infectious and novel vascular brain imaging biomarkers in the relationship of cumulative greenness exposure to cognitive performance and vascular outcomes; and, 3) for whom (individual moderators) and under what conditions (neighborhood moderators) greenness has its impact on cognitive performance and vascular outcomes. We will also examine 4) the longitudinal relationship of cumulative greenness exposure to brain reserve; and 5) the moderating effect of brain reserve in the relationship of greenness to cognitive resilience/performance. Finally, we will 6) explore in post-hoc analyses the relationship of cumulative greenness exposure to adjudicated MCI, AD and ADRD. This proposal builds on the Northern Manhattan Study (NOMAS), a prospective cohort that focuses on risk factors for stroke and cognitive decline in a multi-ethnic/multi-racial aging population. The study of cognitive performance trajectories will be conducted using cognitive performance assessments conducted at three time points (over 10 years minimum) in 1,290 NOMAS participants (with magnetic resonance imaging at baseline). The study of vascular outcomes will include all 3,298 NOMAS participants over ~14 years. Mediating pathways include: 1. Behavioral measures (physical activity; social support); 2. cardiometabolic biomarkers (blood pressure; fasting glucose; BMI; waist circumference); 3. novel inflammatory biomarkers (IL6, TNFR1); and, 4. novel vascular brain imaging biomarkers (white matter hyper-intensity volume, silent brain infarction, cortical thickness). Moderators (for whom and under what conditions) include age, race/ethnicity, sex, education and APOE status, neighborhood income, walkability and crime. Several factors enable us to efficiently and cost-effectively conduct the study, including the rich array of NOMAS data in a diverse sample; availability of archived data on built, natural and social environmental factors for NYC; collaboration of NOMAS study PIs and co-investigators to facilitate smooth data access; and an established and experienced interdisciplinary team of architects and urban planners, biostatisticians, cognitive psychologists, epidemiologists and environmental public health scientists, geographers, and neurologists.

阿尔茨海默氏病和相关痴呆症（AD/ADRD），与年龄相关的认知能力下降，中风和心脏 疾病在种族/少数民族老年人中迫使公共卫生问题高患病率。建筑 在我们的强烈横截面发现中，将绿色暴露（植物存在）连接到较低的速率 慢性疾病 - 包括AD，心脏代谢指标（糖尿病，高血压，高脂血症），心脏 疾病和中风 - 我们建议将邻里绿色暴露为一种新的环境 认知下降和血管结局的保护因素（中风，心肌梗塞[MI]和血管 死亡）。拟议的研究将是第一个前瞻性和纵向研究的研究：1） 累积的绿色暴露于认知表现和血管结果； 2）中介作用 行为，心脏代谢，新颖的炎症/传染性和新型血管脑成像生物标志物 累积绿色与认知表现和血管结局的关系；和，3） 谁（单个主持人）以及在什么条件下（邻里主持人）绿色的影响 关于认知表现和血管结果。我们还将检查4） 累积绿色暴露于大脑储备； 5）大脑储备在 绿色与认知弹性/表现的关系。最后，我们将在事后分析中进行6）探索 累积绿色暴露于调整后的MCI，AD和ADRD之间的关系。 该提案建立在北曼哈顿研究（NOMAS）的基础上，该研究的前瞻性队列侧重于风险 多种族/多种族老龄化人群中风和认知下降的因素。认知研究 绩效轨迹将使用三次进行的认知绩效评估进行 1,290名NOMAS参与者（基线时具有磁共振成像）中的点（至少10年以上）。 对血管结局的研究将包括大约14年以上的所有3,298名NOMAS参与者。中介途径 包括：1。行为测量（体育活动；社会支持）； 2。心脏代谢生物标志物（血液 压力;禁食葡萄糖； BMI;腰围）； 3。新型炎症生物标志物（IL6，TNFR1）；而且，4。 新型血管脑成像生物标志物（白质超强度，无声脑梗塞，皮质 厚度）。主持人（在什么条件下和在什么条件下）包括年龄，种族/种族，性别，教育和 APOE状况，邻里收入，行走性和犯罪。 几个因素使我们能够有效，成本效率地进行研究，包括丰富的阵列 潜水员样本中的NOMAS数据；对建筑，自然和社会环境因素的存档数据的可用性 对于纽约； NOMAS研究PIS和共同投资者的协作，以促进流畅的数据访问；和一个 建立和经验丰富的建筑师和城市规划师，生物统计学家，认知的跨学科团队 心理学家，流行病学家和环境公共卫生科学家，地理学家和神经科医生。