Neighborhood Greenness and Cardiometabolic Health among Hispanics in the HCHS/SOL Study

HCHS/SOL 研究中西班牙裔社区绿化和心脏代谢健康

• 批准号: 10426110
• 负责人: Scott Charles Brown
• 金额: $ 73.19万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10426110
• 关键词: Age; Area; Behavioral; Biological; Biological Markers; Blood Pressure; C-reactive protein; Cardiovascular Diseases; Censuses; Cholesterol; Chronic Kidney Failure; Cities; Code; Communities; Data; Diabetes Mellitus; Diet; Education; Environment; Exposure to; Funding; Grant; HDL(2) Cholesterol; Health; Health Benefit; High Density Lipoprotein Cholesterol; High Density Lipoproteins; Hispanic; Hispanic Community Health Study/Study of Latinos; Hispanic Populations; Hyperlipidemia; Hypertension; Imagery; Incidence; Income; Individual; Inflammation; Infrastructure; Insulin Resistance; Intervention; Latino Population; Link; Location; Longitudinal prospective study; Measures; Mediator of activation protein; Metabolic syndrome; Minority Groups; Modeling; National Heart, Lung, and Blood Institute; Natural experiment; Neighborhoods; Non obese; Obesity; Outcome; Participant; Pathway interactions; Pharmaceutical Preparations; Physical activity; Plants; Policies; Populations at Risk; Research; Resolution; Risk; Risk Factors; Role; Sampling; Science; Site; Sleep; Smoking; Social support; Subgroup; Sum; Time; Trees; Triglycerides; Visit; Woman; biological sex; cardiometabolic risk; cardiometabolism; cost effective; data access; epidemiology study; fasting glucose; high risk; improved; men; mortality; novel; prospective; protective factors; public health relevance; recruit; residential segregation; retention rate; sex; sociodemographics; waist circumference; walkability

Neighborhood Greenness & Cardiometabolic Health among Hispanics in the HCHS/SOL Study ABSTRACT Project Summary: Hispanics/Latinos, the largest U.S. minority group, are at relatively high risk for metabolic syndrome (MetS). Neighborhood greenness (vegetative presence) is a novel and understudied protective factor for MetS that has not yet been systematically studied across Hispanic heritage groups. The NHLBI-funded Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is an epidemiologic study with an emphasis on cardiovascular disease and related risk factors such as MetS, diabetes and hypertension. Building on the HCHS/SOL study, the proposed study will be the first to investigate prospectively and longitudinally, the impact of neighborhood cumulative greenness exposure on MetS indicators within and across Hispanic subgroups. It will do so using the full sample of ~8,000 participants for the Miami and San Diego HCHS/SOL sites, which are two U.S. areas with significant Hispanic/Latino populations. Because both communities are undergoing significant greening interventions, the proposed study will investigate the impact of the natural experiment in greening on MetS in both cities. This proposal will obtain residential location from Visit 1 (2008-2011), Visit 2 (~6 years later), and intervening annual follow-ups to calculate from high resolution satellite imagery cumulative greenness exposure for each participant, and determine its relationship to central adiposity (waist circumference) and 4 other MetS indicators (i.e., blood pressure, triglycerides, low HDL cholesterol, fasting glucose). Cumulative exposure to neighborhood greenness will be assessed, reflecting moves and changes in environments. Multi- group analyses will examine differences in the relationship of cumulative greenness to MetS indicators, by sex, by site and by the three larger Hispanic subgroups. Hypothesized biological pathways will be examined: specifically, greenness’ relationship to changes in waist circumference, which may in turn impact the other 4 MetS indicators through each of: (a) insulin resistance, measured by HOMA-IR, and (b) inflammation, measured by C-Reactive Protein, respectively. Hypothesized moderators (e.g., sex; neighborhood walkability) of greenness to MetS indicators will be examined. Planned post-hoc analyses will examine changes in greenness (e.g., tree-planting) in relation to risk for MetS, diabetes, hypertension, and hyperlipidemia, and possible roles of physical activity and social support (available for a subset of SOL participants) as pathways in the relationship of greenness to biomarkers (insulin resistance, inflammation). HCHS/SOL recently completed Visit 2, making this proposal timely. PIs at the two participating HCHS/SOL Study sites and Coordinating Center will be integral to the conduct of the proposed study. Several factors increase the efficient and cost- effective accomplishment of study aims: effective recruitment/retention strategies; a large array of data on cardiometabolic health outcomes and related behavioral/biological risk factors in a diverse sample of Hispanics/Latinos; a Coordinating Center to facilitate data access; and HCHS/SOL’s team science approach.

HCHS/SOL研究中西班牙裔社区绿化与心脏代谢健康