Neighborhood Greenness and Cardiometabolic Health among Hispanics in the HCHS/SOL Study

HCHS/SOL 研究中西班牙裔社区绿化和心脏代谢健康

• 批准号: 10426110
• 负责人: Scott Charles Brown
• 金额: $ 73.19万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10426110
• 关键词: Age; Area; Behavioral; Biological; Biological Markers; Blood Pressure; C-reactive protein; Cardiovascular Diseases; Censuses; Cholesterol; Chronic Kidney Failure; Cities; Code; Communities; Data; Diabetes Mellitus; Diet; Education; Environment; Exposure to; Funding; Grant; HDL(2) Cholesterol; Health; Health Benefit; High Density Lipoprotein Cholesterol; High Density Lipoproteins; Hispanic; Hispanic Community Health Study/Study of Latinos; Hispanic Populations; Hyperlipidemia; Hypertension; Imagery; Incidence; Income; Individual; Inflammation; Infrastructure; Insulin Resistance; Intervention; Latino Population; Link; Location; Longitudinal prospective study; Measures; Mediator of activation protein; Metabolic syndrome; Minority Groups; Modeling; National Heart, Lung, and Blood Institute; Natural experiment; Neighborhoods; Non obese; Obesity; Outcome; Participant; Pathway interactions; Pharmaceutical Preparations; Physical activity; Plants; Policies; Populations at Risk; Research; Resolution; Risk; Risk Factors; Role; Sampling; Science; Site; Sleep; Smoking; Social support; Subgroup; Sum; Time; Trees; Triglycerides; Visit; Woman; biological sex; cardiometabolic risk; cardiometabolism; cost effective; data access; epidemiology study; fasting glucose; high risk; improved; men; mortality; novel; prospective; protective factors; public health relevance; recruit; residential segregation; retention rate; sex; sociodemographics; waist circumference; walkability

Neighborhood Greenness & Cardiometabolic Health among Hispanics in the HCHS/SOL Study ABSTRACT Project Summary: Hispanics/Latinos, the largest U.S. minority group, are at relatively high risk for metabolic syndrome (MetS). Neighborhood greenness (vegetative presence) is a novel and understudied protective factor for MetS that has not yet been systematically studied across Hispanic heritage groups. The NHLBI-funded Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is an epidemiologic study with an emphasis on cardiovascular disease and related risk factors such as MetS, diabetes and hypertension. Building on the HCHS/SOL study, the proposed study will be the first to investigate prospectively and longitudinally, the impact of neighborhood cumulative greenness exposure on MetS indicators within and across Hispanic subgroups. It will do so using the full sample of ~8,000 participants for the Miami and San Diego HCHS/SOL sites, which are two U.S. areas with significant Hispanic/Latino populations. Because both communities are undergoing significant greening interventions, the proposed study will investigate the impact of the natural experiment in greening on MetS in both cities. This proposal will obtain residential location from Visit 1 (2008-2011), Visit 2 (~6 years later), and intervening annual follow-ups to calculate from high resolution satellite imagery cumulative greenness exposure for each participant, and determine its relationship to central adiposity (waist circumference) and 4 other MetS indicators (i.e., blood pressure, triglycerides, low HDL cholesterol, fasting glucose). Cumulative exposure to neighborhood greenness will be assessed, reflecting moves and changes in environments. Multi- group analyses will examine differences in the relationship of cumulative greenness to MetS indicators, by sex, by site and by the three larger Hispanic subgroups. Hypothesized biological pathways will be examined: specifically, greenness’ relationship to changes in waist circumference, which may in turn impact the other 4 MetS indicators through each of: (a) insulin resistance, measured by HOMA-IR, and (b) inflammation, measured by C-Reactive Protein, respectively. Hypothesized moderators (e.g., sex; neighborhood walkability) of greenness to MetS indicators will be examined. Planned post-hoc analyses will examine changes in greenness (e.g., tree-planting) in relation to risk for MetS, diabetes, hypertension, and hyperlipidemia, and possible roles of physical activity and social support (available for a subset of SOL participants) as pathways in the relationship of greenness to biomarkers (insulin resistance, inflammation). HCHS/SOL recently completed Visit 2, making this proposal timely. PIs at the two participating HCHS/SOL Study sites and Coordinating Center will be integral to the conduct of the proposed study. Several factors increase the efficient and cost- effective accomplishment of study aims: effective recruitment/retention strategies; a large array of data on cardiometabolic health outcomes and related behavioral/biological risk factors in a diverse sample of Hispanics/Latinos; a Coordinating Center to facilitate data access; and HCHS/SOL’s team science approach.

HCHS/SOL研究中西班牙裔的邻里绿色和心脏代谢健康 抽象的 项目摘要： 西班牙裔/拉丁美洲人是美国最大的少数民族群体，其代谢综合征（METS）的风险相对较高。 邻里绿色（植物存在）是一种新颖的，并且可以理解为具有的Mets的受保护因素 在西班牙裔遗产群体中尚未系统地研究。 NHLBI资助的西班牙裔社区 Latinos（HCHS/SOL）的健康研究/研究是一项流行病学研究，重点是心血管 疾病和相关危险因素，例如大都会，糖尿病和高血压。基于HCHS/SOL研究， 拟议的研究将是第一个在邻里的前瞻性和纵向研究的研究 在西班牙裔亚组内部和整个METS指标上的累积绿色暴露。它将使用 迈阿密和圣地亚哥HCHS/SOL网站的约8,000名参与者的完整样本，这是两个美国地区 有重要的西班牙裔/拉丁裔人口。因为两个社区都在经历重大的绿色 干预措施，拟议的研究将研究自然实验在绿色中对Mets的影响 这两个城市。该建议将从访问1（2008-2011），访问2（〜6年后）获得居民地点，并 介入年度随访，从高分辨率卫星图像累积绿色 每次参与的暴露，并确定其与中央肥胖（腰围）和4的关系 其他MetS指标（即血压，甘油三酸酯，低HDL胆固醇，空腹葡萄糖）。累积 将评估接触邻里绿色，反映环境的动作和变化。多- 小组分析将检查累积绿色与Mets指标的关系差异，性别，性别， 按场地和三个较大的西班牙裔亚组。将检查假设的生物途径： 具体而言，绿色与腰围变化的关系，这反过来可能影响其他4 MetS通过每一个：（a）通过HOMA-IR测量的胰岛素抵抗和（b）炎症， 分别通过C反应蛋白测量。假设的主持人（例如，性行为；邻里可行性） 将检查对Mets指标的绿色。计划的事后分析将检查 与大都会，糖尿病，高血压和高脂血症的风险有关的绿色（例如，植树） 体育活动和社会支持的可能作用（可用于SOL参与者的一部分）作为途径 绿色与生物标志物的关系（胰岛素抵抗，炎症）。 HCHS/SOL最近完成 访问2，及时提出此建议。 PI在两个参与的HCHS/SOL研究站点和协调 中心将是拟议研究的行为不可或缺的。几个因素增加了高效和成本 - 有效的研究目标：有效的招聘/保留策略；大量数据 潜水员样本中的心脏代谢健康结果和相关的行为/生物风险因素 西班牙裔/拉丁美洲人；协调中心，以促进数据访问；以及HCHS/SOL的团队科学方法。