Neighborhood Greenness and Cardiometabolic Health among Hispanics in the HCHS/SOL Study

HCHS/SOL 研究中西班牙裔社区绿化和心脏代谢健康

• 批准号: 9973698
• 负责人: Scott Charles Brown
• 金额: $ 79.76万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9973698
• 关键词: Age; Area; Behavioral; Biological; Biological Markers; Blood Pressure; C-reactive protein; Cardiovascular Diseases; Censuses; Cholesterol; Chronic Kidney Failure; Cities; Code; Communities; Data; Diabetes Mellitus; Diet; Education; Environment; Exposure to; Funding; Grant; HDL(2) Cholesterol; Health; Health Benefit; High Density Lipoprotein Cholesterol; High Density Lipoproteins; Hispanic Community Health Study/Study of Latinos; Hispanics; Hyperlipidemia; Hypertension; Imagery; Incidence; Income; Individual; Inflammation; Infrastructure; Insulin Resistance; Intervention; Latino; Link; Location; Longitudinal prospective study; Measures; Mediator of activation protein; Metabolic syndrome; Minority Groups; Modeling; National Heart, Lung, and Blood Institute; Natural experiment; Neighborhoods; Non obese; Obesity; Outcome; Participant; Pathway interactions; Pharmaceutical Preparations; Physical activity; Plants; Policies; Populations at Risk; Research; Resolution; Risk; Risk Factors; Role; Sampling; Science; Site; Sleep; Smoking; Social support; Subgroup; Sum; Time; Trees; Triglycerides; Visit; Woman; biological sex; cardiometabolic risk; cardiometabolism; cost effective; data access; epidemiology study; fasting glucose; high risk; improved; men; mortality; novel; prospective; protective factors; public health relevance; recruit; retention rate; segregation; sex; sociodemographics; waist circumference; walkability

Neighborhood Greenness & Cardiometabolic Health among Hispanics in the HCHS/SOL Study ABSTRACT Project Summary: Hispanics/Latinos, the largest U.S. minority group, are at relatively high risk for metabolic syndrome (MetS). Neighborhood greenness (vegetative presence) is a novel and understudied protective factor for MetS that has not yet been systematically studied across Hispanic heritage groups. The NHLBI-funded Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is an epidemiologic study with an emphasis on cardiovascular disease and related risk factors such as MetS, diabetes and hypertension. Building on the HCHS/SOL study, the proposed study will be the first to investigate prospectively and longitudinally, the impact of neighborhood cumulative greenness exposure on MetS indicators within and across Hispanic subgroups. It will do so using the full sample of ~8,000 participants for the Miami and San Diego HCHS/SOL sites, which are two U.S. areas with significant Hispanic/Latino populations. Because both communities are undergoing significant greening interventions, the proposed study will investigate the impact of the natural experiment in greening on MetS in both cities. This proposal will obtain residential location from Visit 1 (2008-2011), Visit 2 (~6 years later), and intervening annual follow-ups to calculate from high resolution satellite imagery cumulative greenness exposure for each participant, and determine its relationship to central adiposity (waist circumference) and 4 other MetS indicators (i.e., blood pressure, triglycerides, low HDL cholesterol, fasting glucose). Cumulative exposure to neighborhood greenness will be assessed, reflecting moves and changes in environments. Multi- group analyses will examine differences in the relationship of cumulative greenness to MetS indicators, by sex, by site and by the three larger Hispanic subgroups. Hypothesized biological pathways will be examined: specifically, greenness’ relationship to changes in waist circumference, which may in turn impact the other 4 MetS indicators through each of: (a) insulin resistance, measured by HOMA-IR, and (b) inflammation, measured by C-Reactive Protein, respectively. Hypothesized moderators (e.g., sex; neighborhood walkability) of greenness to MetS indicators will be examined. Planned post-hoc analyses will examine changes in greenness (e.g., tree-planting) in relation to risk for MetS, diabetes, hypertension, and hyperlipidemia, and possible roles of physical activity and social support (available for a subset of SOL participants) as pathways in the relationship of greenness to biomarkers (insulin resistance, inflammation). HCHS/SOL recently completed Visit 2, making this proposal timely. PIs at the two participating HCHS/SOL Study sites and Coordinating Center will be integral to the conduct of the proposed study. Several factors increase the efficient and cost- effective accomplishment of study aims: effective recruitment/retention strategies; a large array of data on cardiometabolic health outcomes and related behavioral/biological risk factors in a diverse sample of Hispanics/Latinos; a Coordinating Center to facilitate data access; and HCHS/SOL’s team science approach.

HCHS/SOL 研究中西班牙裔的社区绿化和心脏代谢健康 抽象的 项目概要： 西班牙裔/拉丁裔是美国最大的少数族裔，患代谢综合征 (MetS) 的风险相对较高。 社区绿化（植被存在）是 MetS 的一种新颖且未被充分研究的保护因素，它具有 尚未对西班牙裔遗产群体进行系统研究。 NHLBI 资助的西班牙裔社区 拉丁裔健康研究/拉丁裔研究 (HCHS/SOL) 是一项流行病学研究，重点关注心血管疾病 疾病和相关危险因素，如代谢综合征、糖尿病和高血压。以 HCHS/SOL 研究为基础， 拟议的研究将是第一个前瞻性和纵向调查邻里关系的影响的研究 西班牙裔亚群体内部和跨群体的 MetS 指标的累积绿色暴露度。它将使用 迈阿密和圣地亚哥 HCHS/SOL 站点（这两个美国地区）的约 8,000 名参与者的完整样本 拥有大量西班牙裔/拉丁裔人口。因为两个社区都正在进行大规模绿化 干预措施，拟议的研究将调查绿化中的自然实验对 MetS 的影响 两个城市。该提案将从访问 1（2008-2011）、访问 2（约 6 年后）获得居住位置，以及 每年进行后续跟踪，根据高分辨率卫星图像计算累积绿度 每个参与者的暴露量，并确定其与中心肥胖（腰围）和 4 的关系 其他 MetS 指标（即血压、甘油三酯、低 HDL 胆固醇、空腹血糖）。累计 将评估邻里绿地的暴露程度，反映环境的移动和变化。多- 群体分析将检查累积绿度与 MetS 指标之间关系的差异（按性别、 按地点和三个较大的西班牙裔亚群。将检查假设的生物学途径： 具体来说，绿色度与腰围变化的关系，这可能反过来影响其他 4 个因素 MetS 指标通过以下各项进行：(a) 胰岛素抵抗（通过 HOMA-IR 测量）和 (b) 炎症， 分别通过C-反应蛋白测量。假设的调节因素（例如性别；社区步行能力） 将检查 MetS 指标的绿色度。计划的事后分析将检查以下方面的变化 绿色环保（例如植树）与代谢综合征、糖尿病、高血压和高脂血症的风险相关，以及 身体活动和社会支持（适用于 SOL 参与者的子集）作为途径的可能作用 绿色与生物标志物（胰岛素抵抗、炎症）的关系。 HCHS/SOL 最近完成 访问2，提出这个建议很及时。两个参与 HCHS/SOL 研究中心的 PI 和协调 中心将成为拟议研究的一部分。有几个因素会提高效率和成本 有效实现研究目标：有效的招聘/保留策略；大量数据 不同样本中的心脏代谢健康结果和相关行为/生物风险因素 西班牙裔/拉丁裔；促进数据访问的协调中心；以及 HCHS/SOL 的团队科学方法。