Mechanisms of temporal selectivity in the anuran auditory midbrain

无尾听觉中脑的时间选择性机制

• 批准号: 10531249
• 负责人: GARY J ROSE
• 金额: $ 32.41万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-12-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10531249
• 关键词: Acoustics; Advertisements; Animals; Attenuated; Auditory; Auditory system; Binding; Brain; Brain Stem; Cell Nucleus; Cells; Closure by clamp; Communication; Communities; Computing Methodologies; Cutaneous; Discrimination; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Frequencies; Glutamates; Goals; Human; Impairment; Inferior Colliculus; Iontophoresis; Lateral lemniscus; Mental Depression; Methodology; Midbrain structure; Modeling; Muscimol; N-Methyl-D-Aspartate Receptors; N-Methylaspartate; NMDA receptor antagonist; Neurons; Neurosciences; Pattern; Physiologic pulse; Play; Preparation; Process; Property; Pulse Rates; Rana pipiens; Reproductive Biology; Research; Research Personnel; Role; Signal Transduction; Speech Disorders; Stimulus; Structure; Synapses; Synaptic Transmission; Techniques; Time; Vertebrates; Whole-Cell Recordings; age related; base; experimental study; extracellular; in vivo; insight; neural; neurophysiology; novel; pharmacologic; programs; receptor; response; sound; speech recognition; stem; voltage

The temporal structure of signals plays important roles in communication. The proposed projects aim to provide new insight into how midbrain neurons respond selectively to particular temporal features of communication sounds, specifically pulse rate and duration. Experiments will investigate the role of NMDA-type receptors in amplifying responses and augmenting temporal selectivity. Other experiments will be the first to explore the role of projections from the nucleus of the lateral lemniscus to the inferior colliculus in generating temporal selectivity. Focal pharmacological manipulations will be combined with whole-cell intracellular recordings. We also propose to use new computational methodology to delineate the time course of excitatory and inhibitory conductances. This novel and powerful methodological approach has only recently been applied to the in vivo study of central auditory systems (Rose et al., 2013), and holds great promise for enabling auditory system researchers, as well as the neuroscience community at large, to gain unprecedented insight into the mechanisms that underlie computations in the brain. This approach will also be used to investigate the roles of dynamic properties of inhibition, and thereby evaluate a new model of interval selectivity. The last set of experiments will investigate whether IC neurons of the various temporal selectivity classes respond selectively to particular natural calls of leopard frogs. These new experiments are expected to further our understanding of the network and cellular properties that underlie the temporal selectivity of midbrain neurons.

信号的时间结构在通信中起着重要的作用。 拟议项目 目的是提供新的见解中脑神经元如何选择性地响应特定的时间 通信声音的特征，特别是脉搏率和持续时间。实验将 研究NMDA型受体在放大反应和增加时间的作用， 选择性 其他实验将是第一个探索从大脑投射的作用的实验。 外侧丘系核到下丘的时间选择性。 局灶性药理学操作将与全细胞细胞内记录相结合。 我们 还建议使用新的计算方法来描绘兴奋性和 抑制电导 这种新颖而强大的方法论方法直到最近才被 应用于中枢听觉系统的体内研究（Rose等人，2013年），并保持良好的 承诺使听觉系统研究人员，以及整个神经科学界， 以获得对大脑计算机制的前所未有的深入了解。 这 方法也将被用来调查的作用，抑制的动态特性，从而 评估间隔选择性的新模型。 最后一组实验将研究IC是否 各种时间选择性类的神经元选择性地响应特定的自然调用， 豹蛙 这些新的实验有望进一步加深我们对网络的理解 以及中脑神经元时间选择性的细胞特性。

项目成果

How auditory selectivity for sound timing arises: The diverse roles of GABAergic inhibition in shaping the excitation to interval-selective midbrain neurons.

• DOI: 10.1016/j.pneurobio.2020.101962
• 发表时间: 2021-04
• 期刊: Progress in neurobiology
• 影响因子: 6.7
• 作者: Alluri RK;Rose GJ;Leary CJ;Palaparthi A;Hanson JL;Vasquez-Opazo GA;Graham JA;Luong K
• 通讯作者: Luong K