Multi-site Data for Nutrition Studies in Healthy Early Childhood

健康幼儿营养研究的多站点数据

• 批准号: 10528096
• 负责人: Yangming Ou
• 金额: $ 8.85万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-04 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10528096
• 关键词: Adult; Affect; Archives; Area; Behavior; Birth; Boston; Brain; Brain imaging; Breast Feeding; Carotenoids; Child; Child Health; Childhood; Clinical Trials; Combinatorics; Data; Data Set; Dementia; Demographic Factors; Development; Diet; Dietary intake; Diffusion; Elderly; Environment; Feeding Patterns; Food; Frequencies; Functional Magnetic Resonance Imaging; Funding; Goals; Grant; Health; Hour; Human Development; Human Milk; Infant; Lactation; Letters; Life; Life Style; Link; Magnetic Resonance Imaging; Manuals; Metadata; Milk; Mothers; Motor; National Institute of Child Health and Human Development; Neurocognition; Neurocognitive; Newborn Infant; Nutrient; Outcome; Parents; Participant; Patient Self-Report; Pediatric Hospitals; Pigments; Population; Premature Infant; Process; Questionnaires; Recommendation; Research Personnel; Rest; Sampling; School-Age Population; Site; Socioeconomic Status; Structure; Testing; United States National Institutes of Health; Visit; Woman; autism spectrum disorder; brain health; brain magnetic resonance imaging; cohort; combat; data dictionary; data structure; demographics; density; diaries; dietary; early childhood; follow-up; high risk infant; improved; infancy; macula; morphometry; mother nutrition; neonatal brain; nutrition; offspring; precision nutrition; prospective; recruit; secondary analysis; symposium; user-friendly

Project Summary/Abstract This project aims to release our recently gathered unique data for nutrition studies of healthy term-born infants through school age. Brain development is a major health domain, and infancy is a period when the brain develops most rapidly and is perhaps most vulnerable to the lack of nutrition. Studies on nutrition’s effect on brain health are mostly on the elderly especially dementia populations. Very few studies on nutrition’s effect on brain healthy are on infants, but mostly on infants born pre-term, who clearly need nutrition supplements but only account for ~10% of all newborns. Term-born healthy infants constitute ~90% of newborns, and they pose specific requirement for nutrition, but are rarely studied. In 2014-2018 (clinical trial NCT02058225), we have acquired comprehensive data to study how maternal dietary intake of nutrition impacts healthy term-born infants’ brain health during the first 3 months after birth. In 2019-2020, we have additionally collected neurocognitive outcome questionnaires now that those children are in early school age. Overall, our data were collected in two large women’s and children’s hospitals for 145 healthy mother-infant dyads. Our data include: (1) demographics of parents and infants; (2) food frequency questionnaires (FFQ) of maternal dietary intake of nutrition during lactation, which were already converted into 73 nutrients; (3) milk feeding patterns (breastmilk- or formula, or a combination); (4) socioeconomic status and lifestyle questionnaires from the parents; (5) breastmilk nutrition components; (6) maternal macular pigment ocular density (MPOD), which is an easy-to-obtain, quantitative reflection of specific maternal nutrition in carotenoids; (7) infant brain MRI (structural, diffusion, functional) at 1 and 3-month of life after birth; (8) infant Mullen score reflecting neurocognitive functions at 3 months (e.g., motor); and (9) neurocognitive questionnaires and the converted neurocognitive scores at early school age (4-6 years). We propose to organize the data (Aim 1), process and harmonize multi-site MRI (Aim 2), and publicly-release this otherwise rarely-available comprehensive data (Aim 3). This data can help study how dietary and breastmilk nutrition are related to early-infancy brain structure and function, how they correlate with school-age neurocognition, and how they interact with socioeconomic status and demographic factors.

项目总结/摘要 这个项目旨在发布我们最近收集的健康足月婴儿营养研究的独特数据 到了上学的年龄大脑发育是一个主要的健康领域，婴儿期是大脑发育的时期 最快，也可能是最容易受到营养缺乏的影响。营养对脑健康影响的研究 主要是老年人尤其是痴呆症患者关于营养对大脑健康影响的研究很少 婴儿，但大多数是早产儿，他们显然需要营养补充剂，但只占 约占所有新生儿的10%。足月出生的健康婴儿占新生儿的约90%，他们构成了特定的 营养需求，但很少研究。在2014-2018年（临床试验NCT 02058225），我们获得了 研究母亲膳食营养摄入如何影响健康足月婴儿大脑的全面数据 出生后前三个月的健康状况。在2019-2020年，我们额外收集了神经认知结果 现在这些孩子已经到了上学的年龄。总的来说，我们的数据是在两个大的 妇女和儿童医院为145对健康母婴提供服务。我们的数据包括：（1）人口统计数据 父母和婴儿;（2）食物频率问卷（FFQ）的母亲膳食营养摄入量期间， 哺乳期，其中已经转化为73种营养素;（3）母乳喂养模式（母乳-或配方奶粉，或 组合）;（4）父母的社会经济状况和生活方式问卷;（5）母乳营养 （6）母体黄斑色素眼密度（MPOD），这是一个容易获得的，定量的 类胡萝卜素中特定母体营养的反映;（7）婴儿脑MRI（结构，扩散，功能），1 和出生后3个月的生命;（8）反映3个月时神经认知功能的婴儿马伦评分（例如，motor）; （9）学龄早期（4-6岁）神经认知问卷及转换后的神经认知评分。 我们建议组织数据（目标1），处理和协调多站点MRI（目标2），并公开发布 这一难得的全面数据（目标3）。这些数据可以帮助研究饮食和母乳 营养与婴儿早期的大脑结构和功能有关， 神经认知，以及它们如何与社会经济地位和人口统计学因素相互作用。