Multi-site Data for Nutrition Studies in Healthy Early Childhood

健康幼儿营养研究的多站点数据

• 批准号: 10676921
• 负责人: Yangming Ou
• 金额: $ 8.85万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-04 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10676921
• 关键词: Adolescence; Adult; Affect; Algorithms; Archives; Area; Behavior; Birth; Boston; Brain; Brain imaging; Breast Feeding; Carotenoids; Child; Child Health; Childhood; China; Chinese; Clinical Trials; Combinatorics; Data; Data Set; Dementia; Demographic Factors; Development; Diet; Dietary intake; Diffusion; Elderly; Environment; Feeding Patterns; Food; Food Interactions; Frequencies; Functional Magnetic Resonance Imaging; Funding; Goals; Grant; Health; Hour; Human Development; Human Milk; Infant; Italy; Lactation; Letters; Life; Life Style; Link; Magnetic Resonance Imaging; Manuals; Metadata; Milk; Mothers; Motor; National Institute of Child Health and Human Development; Netherlands; Neurocognition; Neurocognitive; Newborn Infant; Norway; Nutrient; Outcome; Parents; Participant; Patient Self-Report; Pediatric Hospitals; Pigments; Pollution; Population; Poverty; Premature Infant; Process; Questionnaires; Recommendation; Research Personnel; Rest; Sampling; School-Age Population; Site; Socioeconomic Status; Spain; Strategic Planning; Stress; Structure; Testing; United States National Institutes of Health; Visit; Woman; autism spectrum disorder; brain health; brain magnetic resonance imaging; cohort; combat; data dictionary; data structure; demographics; density; diaries; dietary; early childhood; follow-up; high risk infant; improved; infancy; macula; maternal obesity; morphometry; mother nutrition; neonatal brain; nutrition; offspring; precision nutrition; prospective; recruit; secondary analysis; symposium; tool; user-friendly

Project Summary/Abstract This project aims to release our recently gathered unique data for nutrition studies of healthy term-born infants through school age. Brain development is a major health domain, and infancy is a period when the brain develops most rapidly and is perhaps most vulnerable to the lack of nutrition. Studies on nutrition’s effect on brain health are mostly on the elderly especially dementia populations. Very few studies on nutrition’s effect on brain healthy are on infants, but mostly on infants born pre-term, who clearly need nutrition supplements but only account for ~10% of all newborns. Term-born healthy infants constitute ~90% of newborns, and they pose specific requirement for nutrition, but are rarely studied. In 2014-2018 (clinical trial NCT02058225), we have acquired comprehensive data to study how maternal dietary intake of nutrition impacts healthy term-born infants’ brain health during the first 3 months after birth. In 2019-2020, we have additionally collected neurocognitive outcome questionnaires now that those children are in early school age. Overall, our data were collected in two large women’s and children’s hospitals for 145 healthy mother-infant dyads. Our data include: (1) demographics of parents and infants; (2) food frequency questionnaires (FFQ) of maternal dietary intake of nutrition during lactation, which were already converted into 73 nutrients; (3) milk feeding patterns (breastmilk- or formula, or a combination); (4) socioeconomic status and lifestyle questionnaires from the parents; (5) breastmilk nutrition components; (6) maternal macular pigment ocular density (MPOD), which is an easy-to-obtain, quantitative reflection of specific maternal nutrition in carotenoids; (7) infant brain MRI (structural, diffusion, functional) at 1 and 3-month of life after birth; (8) infant Mullen score reflecting neurocognitive functions at 3 months (e.g., motor); and (9) neurocognitive questionnaires and the converted neurocognitive scores at early school age (4-6 years). We propose to organize the data (Aim 1), process and harmonize multi-site MRI (Aim 2), and publicly-release this otherwise rarely-available comprehensive data (Aim 3). This data can help study how dietary and breastmilk nutrition are related to early-infancy brain structure and function, how they correlate with school-age neurocognition, and how they interact with socioeconomic status and demographic factors.

项目摘要/摘要 该项目旨在发布我们最近收集的独特数据，用于健康足月出生婴儿的营养研究 一直到上学年龄。大脑发育是一个主要的健康领域，而婴儿期是大脑发育的时期 这是最快的，也可能是最容易受到营养缺乏影响的。营养对脑健康影响的研究进展 多见于老年人，尤其是痴呆症人群。关于营养对大脑健康影响的研究很少 是针对婴儿的，但主要是早产儿，他们显然需要营养补充剂，但只占 约占所有新生儿的10%。足月出生的健康婴儿占新生儿的90%，他们的姿势特别 对营养的需求，但很少有人研究。2014-2018年(临床试验NCT02058225)，我们获得了 综合数据研究母亲膳食营养摄入量对健康足月儿大脑的影响 出生后3个月内的健康状况。在2019-2020年，我们还收集了神经认知结果 现在这些孩子都在学龄儿童的年龄，问卷调查。总体而言，我们的数据收集在两个大的 妇女和儿童医院为145名健康母婴提供服务。我们的数据包括：(1)人口统计数据 (2)母亲膳食营养摄入量调查问卷(FFQ) 哺乳，已转化为73种营养素；(3)母乳喂养模式(母乳或配方奶，或 (4)父母的社会经济状况和生活方式问卷；(5)母乳营养 (6)母体黄斑色素眼密度(MPOD)，这是一种易于获得的、定量的 母体特定营养在类胡萝卜素中的反映；(7)婴儿大脑MRI(结构、弥散、功能)为1 出生后3个月：(8)反映3个月时神经认知功能的婴儿马伦评分(如运动)； (9)神经认知问卷和学龄早期(4-6岁)的神经认知换算分数。 我们建议组织数据(目标1)，处理和协调多点磁共振(目标2)，并公开发布 这些本来很少获得的综合数据(目标3)。这些数据可以帮助研究饮食和母乳如何 营养与婴幼儿早期的大脑结构和功能有关，以及它们与学龄的关系 神经认知，以及它们如何与社会经济地位和人口因素相互作用。