Novel Strategies for Self-Healing Dental Materials

自修复牙科材料的新策略

• 批准号: 10530744
• 负责人: Ana Paula Piovezan Fugolin
• 金额: $ 24.9万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-12 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10530744
• 关键词: 3D Print; Acrylamides; Agitation; Amides; Area; Biocompatible Materials; Bite Force; Chemistry; Clinical; Composite Resins; Covalent Interaction; Data; Dental; Dental Materials; Development; Diffusion; Dimensions; Emulsions; Encapsulated; Esters; Esthetics; Evaluation; Extravasation; Failure; Filler; Fluorescent Dyes; Formulation; Fracture; Future; Generations; Goals; Growth; Investigation; Kinetics; Knowledge; Laboratories; Lead; Length; Life; Longevity; Mastication; Mentors; Methacrylates; Methods; Microcapsules drug delivery system; Microencapsulations; Modification; Monitor; Odontogenesis; Phase; Physiological; Polymers; Postdoctoral Fellow; Process; Production; Property; Reaction; Reproducibility; Resources; Shapes; Signal Transduction; Standardization; Stress; Structure; Surface; System; Techniques; Technology; Temperature; Testing; Torsion; Translations; Viscosity; base; capsule; clinically relevant; composite restoration; dental resin; design; digital imaging; ethylene glycol; healing; hydrophilicity; improved; innovation; mechanical properties; monomer; novel; novel strategies; polymerization; polymerization stress; premature; prevent; repaired; restoration; restorative dentistry; restorative material; side effect; success; thermal stress; triethylene glycol

A promising strategy to overcome the limited survival of dental restorations lies is the addition of healing microcapsules in the organic matrix of the restorative materials. These capsules, when reached by the crack, are broken and release the healing agent, inhibiting its propagation. However, there are several critical gaps and crucial improvements to make this approach suitable and commercially viable. Our long-term goals are to introduce optimized healing agents, minimize the side effects of addition of the capsules, via shell wall functionalization, and validate advanced method for encapsulation. Previous studies revealed that low viscosity amides are capable of modulating the polymerization reaction, and more tough and degradationresistant than methacrylates, so these compounds are going to be used as alternative healing agents. In addition, thiourethane surface functionalization has been shown to be an efficient method to increase fracture toughness and reduce polymerization stress, so we propose to functionalize the capsule surface with this compound -the methods for functionalization were developed in my post-doctoral mentor's laboratory, which increases the chance of success. Finally, we aim at overcoming the main issues involved in the doubleemulsion method, such as poor size control of the capsules and high sensitivity of the method, by utilizing the green chemistry coaxial electrohydrodynamic atomization (CEHDA) technique for the encapsulation process. In summary, the following Specific Aims are proposed to: (1) Introduce amides as healing agents, (2) Functionalize the microcapsule's surface with thiourethane oligomers, and (3) Improve encapsulation process with advanced technology. The K99 mentored phase has been focused on tailoring and optimizing the microcapsules synthesis in order to encapsulate properly compounds with different hydrophilicities and minimize the healing agent leakage. The second main goal of this phase was to enhance the double torsion fracture toughness technique to assess the healing efficiency and the kinetics of the crack propagation under a more clinically relevant scenario. Collected data has highlighted that the incorporation of the microcapsules into the thermosetting polymeric networks changes dramatically the kinetics of the crack formation and propagation. Therefore, in the independent phase of this proposal, the crack growth kinetics and the polymer healing will be closely monitored by the incorporation of fluorescent dyes into the encapsulated healing agents, the investigation of the magnitude of the effects promoted by the addition of the microcapsules in systems containing the unreacted compound triethylene glycol dibutanoate, and the use of digital image correlation (DIC) technology. The central hypothesis is that the tough healing agent, shell wall functionalization, and introduction of CEHDA method to produce capsules will significantly increase the potential and viability of self-healing dental materials. This proposal will broadly impact the field by modifying and improving essential self-healing components and developing an alternative method for encapsulation process, making this approach a tangible resource for resin composites survival.

克服牙齿修复体存活率有限的一个有前途的策略是增加愈合能力 修复材料有机基质中的微胶囊。这些胶囊，当到达裂缝时， 被破坏并释放愈合剂，抑制其传播。然而，存在几个关键差距 以及使这种方法适用且具有商业可行性的关键改进。我们的长期目标是 通过壳壁引入优化的愈合剂，最大限度地减少添加胶囊的副作用 功能化，并验证先进的封装方法。先前的研究表明，低 粘度酰胺能够调节聚合反应，并且比甲基丙烯酸酯更坚韧、更耐降解，因此这些化合物将被用作替代修复剂。在 此外，硫代氨基甲酸酯表面功能化已被证明是增加断裂的有效方法 韧性并减少聚合应力，因此我们建议用这种方法对胶囊表面进行功能化 化合物 - 功能化方法是在我的博士后导师实验室开发的， 增加成功的机会。最后，我们的目标是通过利用双乳化法克服胶囊尺寸控制差和方法灵敏度高等主要问题。 用于封装的绿色化学同轴电流体雾化（CEHDA）技术 过程。总之，提出以下具体目标：（1）引入酰胺作为愈合剂， (2) 用硫氨酯低聚物对微胶囊表面进行功能化，以及 (3) 改善封装 采用先进技术进行加工。 K99指导阶段的重点是定制和优化 微胶囊的合成，以正确封装具有不同亲水性和亲水性的化合物 最大限度地减少愈合剂的泄漏。这一阶段的第二个主要目标是增强双扭力 断裂韧性技术，用于评估愈合效率和裂纹扩展动力学 更具临床相关性的场景。收集到的数据表明，微胶囊的掺入 进入热固性聚合物网络极大地改变了裂纹形成的动力学 传播。因此，在该提案的独立阶段，裂纹扩展动力学和聚合物 通过将荧光染料掺入封装的愈合中来密切监测愈合情况 剂，研究添加微胶囊所促进的影响程度 含有未反应化合物三甘醇二丁酸酯的体系以及数字图像的使用 相关（DIC）技术。中心假设是坚韧的愈合剂，贝壳壁 功能化，引入CEHDA方法生产胶囊将显着提高 自修复牙科材料的潜力和可行性。该提案将通过修改来广泛影响该领域 改进重要的自愈组件并开发替代封装方法 过程，使这种方法成为树脂复合材料生存的有形资源。