Novel Strategies for Self-Healing Dental Materials
自修复牙科材料的新策略
基本信息
- 批准号:10609093
- 负责人:
- 金额:$ 24.86万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-04-12 至 2025-03-31
- 项目状态:未结题
- 来源:
- 关键词:3D PrintAcrylamidesAgitationAllyAmidesAreaBiocompatible MaterialsBite ForceChemistryClinicalComposite ResinsCovalent InteractionDataDentalDental MaterialsDevelopmentDiffusionDimensionsEmulsionsEncapsulatedEstersEstheticsEvaluationExtravasationFailureFillerFluorescent DyesFormulationFractureFutureGenerationsGoalsGrowthInvestigationKineticsKnowledgeLaboratoriesLeadLengthLifeLongevityMasticationMentorsMethacrylatesMethodsMicrocapsules drug delivery systemModificationMonitorOdontogenesisPhasePhysiologicalPolymersPostdoctoral FellowPredispositionProcessProductionPropertyReactionReproducibilityResourcesShapesSignal TransductionStandardizationStressStructureSurfaceSystemTechniquesTechnologyTemperatureTestingTorsionTranslationsViscosityabsorptioncapsuleclinically relevantcomposite restorationdental resindesigndigital imagingethylene glycolhealinghydrophilicityimprovedinnovationmechanical propertiesmonomernovelnovel strategiespolymerizationpolymerization stressprematurepreventrepairedrestorationrestorative dentistryrestorative materialside effectstress reductionsuccessthermal stresstriethylene glycol
项目摘要
A promising strategy to overcome the limited survival of dental restorations lies is the addition of healing
microcapsules in the organic matrix of the restorative materials. These capsules, when reached by the crack,
are broken and release the healing agent, inhibiting its propagation. However, there are several critical gaps
and crucial improvements to make this approach suitable and commercially viable. Our long-term goals are
to introduce optimized healing agents, minimize the side effects of addition of the capsules, via shell wall
functionalization, and validate advanced method for encapsulation. Previous studies revealed that low
viscosity amides are capable of modulating the polymerization reaction, and more tough and degradationresistant than methacrylates, so these compounds are going to be used as alternative healing agents. In
addition, thiourethane surface functionalization has been shown to be an efficient method to increase fracture
toughness and reduce polymerization stress, so we propose to functionalize the capsule surface with this
compound -the methods for functionalization were developed in my post-doctoral mentor's laboratory, which
increases the chance of success. Finally, we aim at overcoming the main issues involved in the doubleemulsion method, such as poor size control of the capsules and high sensitivity of the method, by utilizing
the green chemistry coaxial electrohydrodynamic atomization (CEHDA) technique for the encapsulation
process. In summary, the following Specific Aims are proposed to: (1) Introduce amides as healing agents,
(2) Functionalize the microcapsule's surface with thiourethane oligomers, and (3) Improve encapsulation
process with advanced technology. The K99 mentored phase has been focused on tailoring and optimizing
the microcapsules synthesis in order to encapsulate properly compounds with different hydrophilicities and
minimize the healing agent leakage. The second main goal of this phase was to enhance the double torsion
fracture toughness technique to assess the healing efficiency and the kinetics of the crack propagation under
a more clinically relevant scenario. Collected data has highlighted that the incorporation of the microcapsules
into the thermosetting polymeric networks changes dramatically the kinetics of the crack formation and
propagation. Therefore, in the independent phase of this proposal, the crack growth kinetics and the polymer
healing will be closely monitored by the incorporation of fluorescent dyes into the encapsulated healing
agents, the investigation of the magnitude of the effects promoted by the addition of the microcapsules in
systems containing the unreacted compound triethylene glycol dibutanoate, and the use of digital image
correlation (DIC) technology. The central hypothesis is that the tough healing agent, shell wall
functionalization, and introduction of CEHDA method to produce capsules will significantly increase the
potential and viability of self-healing dental materials. This proposal will broadly impact the field by modifying
and improving essential self-healing components and developing an alternative method for encapsulation
process, making this approach a tangible resource for resin composites survival.
一个有希望的战略,以克服有限的生存牙科修复谎言是增加愈合
在修复材料的有机基质中的微胶囊。当裂缝到达这些胶囊时,
被打破并释放愈合剂,抑制其传播。然而,有几个关键的差距,
和关键的改进,使这种方法适用和商业可行。我们的长期目标是
为了引入优化的愈合剂,最大限度地减少通过壳壁添加胶囊的副作用,
功能化,并验证先进的封装方法。之前的研究表明,低
粘度酰胺能够调节聚合反应,并且比甲基丙烯酸酯更坚韧和抗降解,因此这些化合物将被用作替代愈合剂。在
此外,硫代氨基甲酸酯表面官能化已被证明是增加断裂的有效方法,
韧性和减少聚合应力,所以我们建议用它来官能化胶囊表面。
化合物-功能化的方法是在我的博士后导师的实验室开发的,
增加了成功的机会。最后,我们的目的是克服涉及的主要问题,在复乳法,如差的大小控制的胶囊和高灵敏度的方法,通过利用
绿色化学同轴电流体动力雾化(CEHDA)技术
过程总之,提出了以下具体目的:(1)引入酰胺作为愈合剂,
(2)用硫代氨基甲酸酯低聚物官能化微胶囊的表面,以及(3)改善封装
用先进的技术加工。K99指导阶段的重点是定制和优化
微胶囊的合成是为了适当地包封具有不同结晶度的化合物,
最大限度地减少愈合剂泄漏。这个阶段的第二个主要目标是增强双扭转
断裂韧性技术,以评估愈合效率和动力学的裂纹扩展下,
更符合临床的情况所收集的数据已经强调,
进入热固性聚合物网络中,显著地改变了裂纹形成的动力学,
传播因此,在本建议的独立阶段,裂纹扩展动力学和聚合物
通过将荧光染料掺入包封的愈合中来密切监测愈合
通过将微胶囊添加到药物组合物中,研究了通过在药物组合物中添加微胶囊促进的效果的大小。
含有未反应的化合物三甘醇二丁酸酯的系统,以及数字图像的用途
相关(DIC)技术。中心假设是坚韧的愈合剂,壳壁
功能化,并引入CEHDA方法生产胶囊将显着增加
自愈合牙科材料的潜力和可行性。该提案将通过修改
并改进基本的自我修复组件,开发一种替代封装方法,
工艺,使这种方法成为树脂复合材料生存的有形资源。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Ana Paula Piovezan Fugolin其他文献
Ana Paula Piovezan Fugolin的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Ana Paula Piovezan Fugolin', 18)}}的其他基金
Bio-Responsive and Immune Protein-Based Therapies for Inhibition of Proteolytic Enzymes in Dental Tissues
用于抑制牙齿组织中蛋白水解酶的基于生物响应和免疫蛋白的疗法
- 批准号:
10555093 - 财政年份:2023
- 资助金额:
$ 24.86万 - 项目类别:
Novel Strategies for Self-Healing Dental Materials
自修复牙科材料的新策略
- 批准号:
10530744 - 财政年份:2022
- 资助金额:
$ 24.86万 - 项目类别:
Novel Strategies for Self-Healing Dental Materials
自修复牙科材料的新策略
- 批准号:
9804546 - 财政年份:2019
- 资助金额:
$ 24.86万 - 项目类别:
Novel Strategies for Self-Healing Dental Materials
自修复牙科材料的新策略
- 批准号:
10006815 - 财政年份:2019
- 资助金额:
$ 24.86万 - 项目类别:
相似海外基金
Novel Polymerization System of Acrylamides in the Presence of the Polymers having the Lower Critical Solution Temperature in Water
具有较低水中临界溶液温度的聚合物存在下的新型丙烯酰胺聚合体系
- 批准号:
14550841 - 财政年份:2002
- 资助金额:
$ 24.86万 - 项目类别:
Grant-in-Aid for Scientific Research (C)