Novel Strategies for Self-Healing Dental Materials
自修复牙科材料的新策略
基本信息
- 批准号:10006815
- 负责人:
- 金额:$ 10.87万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-04 至 2022-03-31
- 项目状态:已结题
- 来源:
- 关键词:3D PrintAcrylamidesAgitationAmidesAreaBite ForceChemistryClinicalComposite ResinsCovalent InteractionDataDental MaterialsDevelopmentDiffusionDimensionsEmulsionsEncapsulatedEstersEstheticsEvaluationFaceFailureFillerFoundationsFractureFutureGoalsGrowthHigh Pressure Liquid ChromatographyKineticsLaboratoriesLeadLifeLongevityMasticationMentorsMethacrylatesMethodsMicrocapsules drug delivery systemMicroencapsulationsModificationPhasePhysiologicalProcessProductionPropertyProsthodontic specialtyPrunella vulgarisReactionReproducibilityResearchResearch PersonnelResistanceResourcesShapesSolidSpectrum AnalysisStandardizationStressStructureSurfaceSystemTechniquesTechnologyTemperatureTestingTrainingTranslationsViscosityWalkersbasecapsulecareercomposite restorationdesignhealingimprovedinnovationmechanical propertiesmonomernovelnovel strategiesoral conditionpolymerizationpolymerization stressprematurepreventrepairedrestorationrestorative compositeside effectskillssuccessthermal stress
项目摘要
PROJECT SUMMARY/ABSTRACT
Resin composite restoration failure is strongly associated to internal microcracks caused by the masticatory
forces. A promising strategy to overcome this shortcoming lies is the addition of healing microcapsules in the
organic matrix. These capsules, when reached by the crack, are broken and release the healing agent,
inhibiting its propagation. However, there are several critical gaps and crucial improvements to make this
approach suitable and commercially viable. Our long-term goals are to introduce optimized healing agents,
minimize the side effects of addition of the capsules, via shell wall functionalization, and validate advanced
method for encapsulation. Previous studies revealed that low viscosity amides are capable of modulating the
polymerization reaction, and more tough and degradation-resistant than methacrylates, so these compounds
are going to be used as alternative healing agents. In addition, thiourethane surface functionalization has
been shown to be an efficient method to increase fracture toughness and reduce polymerization stress, so
we propose to functionalize the capsule surface with this compound – the methods for functionalization were
developed in our laboratory, which increases the chance of success. Finally, we will aim at overcoming the
main issues involved in the double-emulsion method, such as poor size control of the capsules and high
sensitivity of the method, by utilizing coaxial electrohydrodynamic atomization (CEHDA) technique for the
encapsulation process. In summary, the following Specific Aims are proposed: (1) To introduce amides as
healing agents, (2) To functionalize the microcapsule’s surface with thiourethane oligomers, and (3) To
improve encapsulation process with advanced technology. Capsules will be characterized by SEM, HPLC,
and Mid-IR spectroscopy. Self-healing composites will be tested for: kinetics, DMA, and mechanical
properties under simulate oral conditions, and finally, the healing process analyzed by Serial Block-Face
SEM. The central hypothesis is that the tough healing agent, shell wall functionalization, and introduction of
CEHDA method to produce capsules will significantly increase the potential and viability of self-healing dental
materials. The skills and new techniques necessary to accomplish the research plan will be acquired from
the mentoring team (Drs. Carmem Pfeifer, Jack Ferracane, Luiz Bertassoni, Mary Anne Melo, Sung Yi and
Travis Walker), who have pioneering expertise in using the proposed methods and strategies.
Complementary background will be gained from seminars, structured tutorials and courseworks. The
combination of the new skills learned during the K99 mentored phase with my prior expertise in dental
materials characterization, and the advanced clinical training in Prosthodontics will lay the foundation of my
independent career, focused on smart dental materials. Additionally, this proposal will broadly impact the
field by modifying and improving essential self-healing components and developing an alternative method for
encapsulation process, making this approach a tangible resource for resin composites survival.
项目总结/摘要
树脂复合体修复失败与咀嚼引起的内部微裂纹密切相关
力.克服这一缺点的一种有希望的策略是在组合物中加入愈合微胶囊。
有机基质当裂缝到达这些胶囊时,这些胶囊被打破并释放愈合剂,
抑制其繁殖。然而,要做到这一点,存在几个关键差距和关键改进
方法合适且商业上可行。我们的长期目标是引入优化的治疗剂,
通过壳壁功能化,最大限度地减少添加胶囊的副作用,并验证先进的
封装方法。以前的研究表明,低粘度酰胺能够调节
聚合反应,比甲基丙烯酸酯更坚韧和抗降解,因此这些化合物
将被用作替代治疗剂。此外,硫代氨基甲酸酯表面官能化具有
已被证明是提高断裂韧性和降低聚合应力的有效方法,
我们建议用该化合物使胶囊表面官能化-官能化的方法是
在我们的实验室里,这增加了成功的机会。最后,我们将致力于克服
双乳液法中涉及的主要问题,例如胶囊的尺寸控制差和高的粘度。
该方法的灵敏度,通过利用同轴电流体动力雾化(CEHDA)技术,
封装工艺。总之,提出了以下具体目标:(1)引入酰胺作为
愈合剂,(2)用硫代氨基甲酸酯低聚物使微胶囊表面官能化,以及(3)
采用先进技术改进封装工艺。胶囊将通过SEM、HPLC、
和中红外光谱自愈合复合材料将进行测试:动力学,DMA和机械
在模拟口腔条件下的性能,最后,用串行块面分析愈合过程
SEM等中心假设是坚韧愈合剂、壳壁功能化和
CEHDA方法生产的胶囊将显着增加的潜力和可行性的自我愈合的牙科
材料.完成研究计划所需的技能和新技术将从
指导小组(Carriage Pfeifer、Jack Ferracane、Luiz Bertassoni、玛丽安妮梅洛、Sung Yi和
特拉维斯步行者),谁拥有开创性的专业知识,在使用所提出的方法和战略。
补充背景将获得研讨会,结构化教程和课程。的
结合K99辅导阶段学到的新技能和我以前在牙科方面的专业知识,
材料表征,以及口腔修复学的高级临床培训将奠定我的基础
独立职业,专注于智能牙科材料。此外,该提案将广泛影响
通过修改和改进基本的自我修复组件,并开发一种替代方法,
封装工艺,使这种方法成为树脂复合材料生存的有形资源。
项目成果
期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
专利数量(0)
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Ana Paula Piovezan Fugolin其他文献
Ana Paula Piovezan Fugolin的其他文献
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{{ truncateString('Ana Paula Piovezan Fugolin', 18)}}的其他基金
Bio-Responsive and Immune Protein-Based Therapies for Inhibition of Proteolytic Enzymes in Dental Tissues
用于抑制牙齿组织中蛋白水解酶的基于生物响应和免疫蛋白的疗法
- 批准号:
10555093 - 财政年份:2023
- 资助金额:
$ 10.87万 - 项目类别:
Novel Strategies for Self-Healing Dental Materials
自修复牙科材料的新策略
- 批准号:
10530744 - 财政年份:2022
- 资助金额:
$ 10.87万 - 项目类别:
Novel Strategies for Self-Healing Dental Materials
自修复牙科材料的新策略
- 批准号:
10609093 - 财政年份:2022
- 资助金额:
$ 10.87万 - 项目类别:
Novel Strategies for Self-Healing Dental Materials
自修复牙科材料的新策略
- 批准号:
9804546 - 财政年份:2019
- 资助金额:
$ 10.87万 - 项目类别:
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