Novel Strategies for Self-Healing Dental Materials

自修复牙科材料的新策略

• 批准号: 9804546
• 负责人: Ana Paula Piovezan Fugolin
• 金额: $ 10.87万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-04 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9804546
• 关键词: 3D Print; Acrylamides; Agitation; Amides; Area; Bite Force; Chemistry; Clinical; Composite Resins; Covalent Interaction; Data; Dental Materials; Development; Diffusion; Dimensions; Emulsions; Encapsulated; Esters; Esthetics; Evaluation; Face; Failure; Filler; Foundations; Fracture; Future; Goals; Growth; High Pressure Liquid Chromatography; Kinetics; Laboratories; Lead; Life; Longevity; Mastication; Mentors; Methacrylates; Methods; Microcapsules drug delivery system; Microencapsulations; Modification; Phase; Physiological; Process; Production; Property; Prosthodontic specialty; Prunella vulgaris; Reaction; Reproducibility; Research; Research Personnel; Resistance; Resources; Shapes; Solid; Spectrum Analysis; Standardization; Stress; Structure; Surface; System; Techniques; Technology; Temperature; Testing; Training; Translations; Viscosity; Walkers; base; capsule; career; composite restoration; design; healing; improved; innovation; mechanical properties; monomer; novel; novel strategies; oral condition; polymerization; polymerization stress; premature; prevent; repaired; restoration; restorative composite; side effect; skills; success; thermal stress

PROJECT SUMMARY/ABSTRACT Resin composite restoration failure is strongly associated to internal microcracks caused by the masticatory forces. A promising strategy to overcome this shortcoming lies is the addition of healing microcapsules in the organic matrix. These capsules, when reached by the crack, are broken and release the healing agent, inhibiting its propagation. However, there are several critical gaps and crucial improvements to make this approach suitable and commercially viable. Our long-term goals are to introduce optimized healing agents, minimize the side effects of addition of the capsules, via shell wall functionalization, and validate advanced method for encapsulation. Previous studies revealed that low viscosity amides are capable of modulating the polymerization reaction, and more tough and degradation-resistant than methacrylates, so these compounds are going to be used as alternative healing agents. In addition, thiourethane surface functionalization has been shown to be an efficient method to increase fracture toughness and reduce polymerization stress, so we propose to functionalize the capsule surface with this compound – the methods for functionalization were developed in our laboratory, which increases the chance of success. Finally, we will aim at overcoming the main issues involved in the double-emulsion method, such as poor size control of the capsules and high sensitivity of the method, by utilizing coaxial electrohydrodynamic atomization (CEHDA) technique for the encapsulation process. In summary, the following Specific Aims are proposed: (1) To introduce amides as healing agents, (2) To functionalize the microcapsule’s surface with thiourethane oligomers, and (3) To improve encapsulation process with advanced technology. Capsules will be characterized by SEM, HPLC, and Mid-IR spectroscopy. Self-healing composites will be tested for: kinetics, DMA, and mechanical properties under simulate oral conditions, and finally, the healing process analyzed by Serial Block-Face SEM. The central hypothesis is that the tough healing agent, shell wall functionalization, and introduction of CEHDA method to produce capsules will significantly increase the potential and viability of self-healing dental materials. The skills and new techniques necessary to accomplish the research plan will be acquired from the mentoring team (Drs. Carmem Pfeifer, Jack Ferracane, Luiz Bertassoni, Mary Anne Melo, Sung Yi and Travis Walker), who have pioneering expertise in using the proposed methods and strategies. Complementary background will be gained from seminars, structured tutorials and courseworks. The combination of the new skills learned during the K99 mentored phase with my prior expertise in dental materials characterization, and the advanced clinical training in Prosthodontics will lay the foundation of my independent career, focused on smart dental materials. Additionally, this proposal will broadly impact the field by modifying and improving essential self-healing components and developing an alternative method for encapsulation process, making this approach a tangible resource for resin composites survival.

项目摘要/摘要 树脂复合体修复失败与咀嚼引起的内部微裂纹密切相关 力量。克服这一缺点的一个有希望的策略是在心脏中添加治疗微囊。 有机基质。当这些胶囊被裂缝触及时，就会破裂并释放出治愈剂， 抑制其传播。然而，要做到这一点，有几个关键的差距和关键的改进 这种方法是合适的，在商业上是可行的。我们的长期目标是引入优化的治愈剂， 通过壳壁功能化将添加胶囊的副作用降至最低，并验证高级 用于封装的方法。先前的研究表明，低粘度的酰胺能够调节 聚合反应，比甲基丙烯酸酯更坚韧，更耐降解，所以这些化合物 将被用作替代的治愈剂。此外，硫代乙烷表面官能化还具有 已被证明是提高断裂韧性和降低聚合应力的有效方法，因此 我们建议用这种化合物来功能化胶囊表面-功能化的方法是 在我们实验室开发的，这增加了成功的机会。最后，我们将致力于克服 复乳法存在的主要问题是胶囊剂的大小控制不好、包封率高等。 方法的灵敏度，通过利用同轴电液动力雾化(CEHDA)技术 封装过程。综上所述，建议的具体目标如下：(1)引入酰胺为 治愈剂，(2)用硫代低聚物使微胶囊表面官能化，以及(3) 用先进的技术改进封装工艺。胶囊将通过扫描电子显微镜、高效液相色谱、 和中红外光谱。将对自修复复合材料进行以下测试：动力学、DMA和机械 在模拟口腔条件下的特性，最后，用Serial Block-Face分析了愈合过程 扫描电子显微镜。中心假设是，坚韧的愈合剂，壳壁的功能化，以及引入 CEHDA法生产胶囊剂将显著提高牙科自愈的潜能和生存能力 材料。完成研究计划所需的技能和新技术将从 指导团队(Carmem Pfeifer博士、Jack Ferracane博士、Luiz Bertassoni博士、Mary Anne Melo博士、宋毅博士和 Travis Walker)，他们在使用提议的方法和策略方面具有开创性的专业知识。 补充的背景将从研讨会、结构化的教程和课程中获得。这个 在K99指导阶段学到的新技能与我以前在牙科方面的专业知识相结合 材料特色化和口腔修复学的高级临床培训将为我的 独立职业，专注于智能牙科材料。此外，这项提议将广泛影响 通过修改和改进基本的自愈组件并开发一种替代方法来实现 封装工艺，使这种方法成为树脂复合材料生存的有形资源。