Co-creation of digital tools to enhance young adult minority participation in COVID-19 trials

共同创建数字工具，以增强少数族裔年轻人对 COVID-19 试验的参与

• 批准号: 10531506
• 负责人: Timothy Ken Mackey
• 金额: $ 96.83万
• 依托单位: CALIFORNIA STATE UNIVERSITY FULLERTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2024-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10531506
• 关键词: Co; creation; digital; tools; enhance

PROJECT SUMMARY/ABSTRACT Increasing young adult racial and ethnic minorities’ participation in COVID-19 clinical trials is an essential component of reducing health disparities in the uptake of COVID-19 vaccinations and treatment burden. Yet, several obstacles hinder racial/ethnic minority participation in trials, including structural barriers associated with lack of financial resources, access and transportation issues, and group-specific issues such as mistrust of the medical/research community or concerns about medical experimentation. Although extensive research has focused on addressing the low participation of minority and underrepresented communities in clinical research, meeting 21st century goals of creating inclusive clinical trials that are representative of rapidly changing and increasingly diverse patient demographics in the United States remains a significant challenge. The proposed project is novel and fills a critical research and innovation gap by directly addressing the complex intersectionality of COVID-19 clinical trials and health equity using several interdisciplinary methods of inquiry. The objective of the proposed project is to utilize novel approaches involving big data, machine learning, data science, and community-driven qualitative research to develop and evaluate a digital tool to encourage young minority adults to participate in the clinical trial process. Through data mining and geospatial analysis of ClinicalTrials.gov, insights into which communities in the United States are underrepresented in the context of access to COVID- 19 clinical trials will be developed (Aim 1), while big data and machine learning approaches will be used to characterize user self-reported knowledge, attitudes, and lived experiences related to COVID-19 on social media platforms (Aim 2). Focus group discussions will be used to engage in deep exploration of specific rationalities, cultural norms, and historical influences related to COVID-19 clinical research engagement with minority young adults (Aim 3). Data collected from these multiple sources will serve as the basis of a protocol to ideate, co- create, and jointly design a digital health tool to encourage clinical trial participation among young adult minority populations through co-design sessions and pilot testing held with racial/ethnic minority young adults (Aim 4). The efficacy of the digital health tool will be evaluated by conducting a controlled before-and-after study among a population of young adult college students at a university designated as a Minority Serving Institution (Aim 5). The proposed project will result in a digital health tool designed to increase young adult participation in COVID- 19 clinical trials.

项目总结/摘要 增加年轻成年种族和少数民族参与COVID-19临床试验是至关重要的 减少COVID-19疫苗接种和治疗负担方面的健康差距的组成部分。然而， 一些障碍阻碍种族/族裔少数群体参与审判，包括与下列方面有关的结构性障碍： 缺乏财政资源、出入和交通问题，以及诸如不信任 医学/研究社区或对医学实验的关注。尽管广泛的研究 重点解决少数族裔和代表性不足的社区在临床研究中参与度低的问题， 满足创建包容性临床试验的21世纪世纪目标， 在美国，日益多样化的患者人口统计仍然是一个重大挑战。拟议 该项目是新颖的，通过直接解决复杂的交叉性，填补了关键的研究和创新空白 COVID-19临床试验和健康公平性的研究。的目标 拟议的项目是利用涉及大数据、机器学习、数据科学和 社区驱动的定性研究，以开发和评估数字工具，鼓励年轻的少数群体成年人 参与临床试验过程。通过对www.example.com的数据挖掘和地理空间分析， 深入了解美国社区在获得COVID方面的代表性不足， 将开发19项临床试验（目标1），而大数据和机器学习方法将用于 描述用户在社交媒体上自我报告的与COVID-19相关的知识、态度和生活经历 平台（目标2）。焦点小组讨论将用于深入探讨具体的合理性， 与少数民族年轻人参与COVID-19临床研究相关的文化规范和历史影响 成人（目标3）。从这些多个来源收集的数据将作为一个协议的基础，以构思，共同， 创建并联合设计数字健康工具，以鼓励年轻成年少数群体参与临床试验 通过与少数种族/族裔青年举行的共同设计会议和试点测试，为人口提供更多的信息（目标4）。 数字健康工具的有效性将通过在受试者中进行对照的前后研究来评估。 在被指定为少数民族服务机构（目标5）的大学里的年轻成人大学生。 拟议的项目将产生一个数字健康工具，旨在增加年轻人对COVID的参与- 19篇临床试验