NYU Collaborative Center In Children's Environmental Health Research and Translation

项目概要（总体） NIEHS/EPA儿童环境健康和疾病预防中心迅速 揭示了化学危害对疾病和残疾的影响。取得实质性进展 制定减少接触的干预措施，但干预措施的吸收和采用仍然有限， 社区和系统层面，在公共卫生实践中，和国家。大多数干预措施没有得到 适应不同的人群或环境，也不是典型的规模设计，特别是低收入， 少数民族和健康知识水平低的人群，不成比例地接触。很少有研究严格地 量化了制造业变化、政策干预或饮食和其他行为的影响， 旨在减少接触的干预措施。为了实现更高的全人群影响，CEH的研究人员 需要传播研究、实施科学方法和公共卫生实践方面的专门知识 跨越转换桥梁并在扩大循证干预措施方面取得成功的框架 以达到最大的影响。我们提议的纽约大学合作中心的目标是， 儿童环境健康研究和翻译（CEHRT）将作为CEH的资源 社区：（1）制定有希望扩大规模的有意义的预防和干预战略，（2） 使这些战略适应不同的人群或环境，以实现更高的全人群影响，以及（3） 严格量化制造业变化、政策干预或饮食和其他 旨在减少暴露的行为干预措施。NYU CEHRT联合了四个现有的专业知识 翻译中心，以满足这些紧迫的挑战，并保护儿童免受环境危害。的 纽约大学CEHRT的交叉主题包括：干预测试，实施科学，健康公平和 经济评价纽约大学CEHRT也是两个环境对儿童健康结果的影响的所在地 （ECHO）队列研究中心（UH 3 OD 023305和UH 3 OD 023332），因此非常适合整合 ECHO和更广泛的CEH社区可能会出现有关新风险的新知识。它 利用了世界级分析化学家Kurunthachalam Kannan的专业知识，他的NIEHS Human 健康暴露分析资源实验室（U2 CES 026452）可以支持和激励创新试点 严格检查饮食、行为改变引起的接触生物标志物变化的项目 家庭因素。NYU CEHRT将创造一个强大的，指导性的培训环境， 支持早期研究者在有前途的时间敏感性、应用性或干预性CEH方面的创新 research.它将通过创新的试点项目来测试和适应， 在不同的环境中采取有希望的或循证的干预措施，并利用实施科学和 传播研究框架，以提高CEH研究成果的吸收和采用。

PROJECT SUMMARY (OVERALL) The NIEHS/EPA Children's Environmental Health (CEH) and Disease Prevention Centers have rapidly unraveled the contribution of chemical hazards to disease and disability. Substantial progress has been made to develop interventions that reduce exposure, yet uptake and adoption of interventions remains limited at the community and systems levels, in public health practice, and nationally. Most interventions have not been adapted for diverse populations or settings, nor are they typically designed to scale, especially for low-income, minority and low health literacy populations with disproportionate exposure. And few studies have rigorously quantified the impacts of manufacturing changes, policy interventions, or dietary and other behavioral interventions designed to reduce exposure. To achieve higher population-wide impact, CEH researchers require expertise on dissemination research, implementation science methods and public health practice frameworks to cross the translational bridge and achieve success in scaling evidence-based interventions across communities for maximum impact. The objective of our proposed NYU Collaborative Center in Children's Environmental Health Research and Translation (CEHRT) is to serve as a Resource for the CEH community by: (1) developing meaningful prevention and intervention strategies that have promise to scale, (2) adapting these strategies for diverse populations or settings, to achieve higher population-wide impact, and (3) rigorously quantifying the impacts of manufacturing changes, policy interventions, or dietary and other behavioral interventions designed to reduce exposure. NYU CEHRT unites the expertise of four existing translational Centers to meet these urgent challenges and protect children from environmental hazards. The cross-cutting themes of NYU CEHRT include: intervention testing, implementation science, health equity and economic evaluation. NYU CEHRT is also home to two Environmental Influences on Child Health Outcomes (ECHO) cohort centers (UH3OD023305 and UH3OD023332), and therefore extremely well-poised to integrate new knowledge about emerging exposures likely to emerge from ECHO and the broader CEH community. It leverages the expertise of a world-class analytical chemist, Kurunthachalam Kannan, whose NIEHS Human Health Exposure Analysis Resource laboratory (U2CES026452) can support and stimulate innovative pilot projects to rigorously examine changes in biomarkers of exposure resulting from modifications in diet, behavior and household factors. NYU CEHRT will create a robust, mentored training environment that stimulates and supports innovation by early stage investigators in promising time-sensitive, applied or interventional CEH research. It will advance translational CEH research through innovative pilot projects to test and adapt promising or evidence-based interventions in diverse settings, and utilize implementation science and dissemination research frameworks to improve uptake and adoption of CEH research findings.