NYU Collaborative Center In Children's Environmental Health Research and Translation

项目总结(总体) NIEHS/EPA儿童环境健康和疾病预防中心迅速 揭示了化学危害对疾病和残疾的贡献。已经取得了实质性进展 制定减少暴露的干预措施，但在 在社区和系统层面、在公共卫生实践中以及在全国范围内。大多数干预措施都没有 适应不同的人群或环境，通常也不是按规模设计的，特别是针对低收入者， 少数群体和低健康素养人群暴露在不成比例的环境中。很少有研究能严格地 量化制造业变化、政策干预或饮食和其他行为的影响 旨在减少暴露的干预措施。为了实现更大的人口范围影响，CEH研究人员 需要传播研究、实施科学方法和公共卫生实践方面的专业知识 跨越转换桥梁并在扩大循证干预措施方面取得成功的框架 跨社区，以实现最大影响。我们提议的纽约大学合作中心的目标是 儿童环境健康研究与翻译(CEHRT)将作为CEH的资源 社区：(1)制定有意义的预防和干预战略，有希望扩大规模，(2) 使这些战略适用于不同的人群或环境，以实现更大的全人群影响，以及(3) 严格量化制造业变化、政策干预或饮食和其他因素的影响 旨在减少暴露的行为干预。纽约大学CEHRT整合了四个现有的专业知识 翻译中心，以应对这些紧迫的挑战，并保护儿童免受环境危害。这个 纽约大学CEHRT的交叉主题包括：干预测试、实施科学、卫生公平和 经济评价。纽约大学CEHRT也有两个环境对儿童健康结果的影响 (ECHO)队列中心(UH3OD023305和UH3OD023332)，因此非常有可能整合 ECHO和更广泛的CEH社区可能会出现关于新兴风险敞口的新知识。它 利用世界级分析化学家库伦萨查拉姆·卡南的专业知识，他的NIEHS Human 健康暴露分析资源实验室(U2CES026452)可支持和激励创新试点 严格检查饮食、行为改变引起的暴露生物标志物变化的项目 和家庭因素。纽约大学CEHRT将创造一个强大的、有指导的培训环境，以刺激和 支持早期研究人员在承诺时间敏感型、应用型或干预性CEH方面的创新 研究。它将通过创新的试点项目推进CEH的翻译研究，以测试和适应 在不同的环境中采取有希望的或基于证据的干预措施，并利用执行科学和 传播研究框架，以改进对CEH研究成果的理解和采用。

PROJECT SUMMARY (OVERALL) The NIEHS/EPA Children's Environmental Health (CEH) and Disease Prevention Centers have rapidly unraveled the contribution of chemical hazards to disease and disability. Substantial progress has been made to develop interventions that reduce exposure, yet uptake and adoption of interventions remains limited at the community and systems levels, in public health practice, and nationally. Most interventions have not been adapted for diverse populations or settings, nor are they typically designed to scale, especially for low-income, minority and low health literacy populations with disproportionate exposure. And few studies have rigorously quantified the impacts of manufacturing changes, policy interventions, or dietary and other behavioral interventions designed to reduce exposure. To achieve higher population-wide impact, CEH researchers require expertise on dissemination research, implementation science methods and public health practice frameworks to cross the translational bridge and achieve success in scaling evidence-based interventions across communities for maximum impact. The objective of our proposed NYU Collaborative Center in Children's Environmental Health Research and Translation (CEHRT) is to serve as a Resource for the CEH community by: (1) developing meaningful prevention and intervention strategies that have promise to scale, (2) adapting these strategies for diverse populations or settings, to achieve higher population-wide impact, and (3) rigorously quantifying the impacts of manufacturing changes, policy interventions, or dietary and other behavioral interventions designed to reduce exposure. NYU CEHRT unites the expertise of four existing translational Centers to meet these urgent challenges and protect children from environmental hazards. The cross-cutting themes of NYU CEHRT include: intervention testing, implementation science, health equity and economic evaluation. NYU CEHRT is also home to two Environmental Influences on Child Health Outcomes (ECHO) cohort centers (UH3OD023305 and UH3OD023332), and therefore extremely well-poised to integrate new knowledge about emerging exposures likely to emerge from ECHO and the broader CEH community. It leverages the expertise of a world-class analytical chemist, Kurunthachalam Kannan, whose NIEHS Human Health Exposure Analysis Resource laboratory (U2CES026452) can support and stimulate innovative pilot projects to rigorously examine changes in biomarkers of exposure resulting from modifications in diet, behavior and household factors. NYU CEHRT will create a robust, mentored training environment that stimulates and supports innovation by early stage investigators in promising time-sensitive, applied or interventional CEH research. It will advance translational CEH research through innovative pilot projects to test and adapt promising or evidence-based interventions in diverse settings, and utilize implementation science and dissemination research frameworks to improve uptake and adoption of CEH research findings.