Imaging Core (Core C)

摘要：核心C-成像核心 成像核心通过以下方式支持哈佛老龄化大脑研究(HABS)计划项目拨款(PPG) 监督所有成像协议的采集和分析。对于更新，成像核心将具有 主要负责为11C匹兹堡化合物B(PIB)和 18F Flortaucipir(Ftp)。核心将负责基础磁共振成像的采集和分析处理 为所有HABS参与者生成标准体积MRI变量的序列，包括PET采样 在MRI定义的感兴趣区(ROI)。核心将提供基本协议图像数据，以与 高级成像协议(项目3)，包括FDG、R1和TARP。所有核心图像数据都将 与核心B：临床核心的数据集成在DataCentral数据库中，由核心D监督： 分析核心。与分析核心相结合，项目1至4中每个项目的人员将能够 查询数据库以获取用于测试单个项目的完全质量控制的图像数据 假设。对于淀粉样蛋白和tau沉积的初步评估，Core将提供标准的完整 PIB PET的动态协议和FTPPET的标准后期帧协议(目标1)。基础磁共振成像 协议将由一套标准化的结构和功能获取组成，用于确定对象的特征， 包括皮质下体积测量，如海马体和皮质厚度(目标1)。标准衡量标准 核心从这些数据集中得出的数据将被所有四个项目用来实现各自的项目目标 (目标2)。这些指标包括以单个或聚合的PET指标实现的淀粉样蛋白和tau的代理指标 组织ROI，例如，以PIB分布体积比(DVR)或区域tau表示的全球淀粉样蛋白负荷 负荷表现为较低的颞叶FTP标准化摄取比(SUVR)。加工流水线 使用基于Freesurfer、SPM12、FSL和内部脚本的工具组合实现自动化 程序。成像核心将为四个PPG项目提供经过质量检查的MRI和PET ROI数据 已在分析核心的监督下对其进行存档和管理。成像核心是 由一批经过放射学专业培训的临床神经影像研究人员组成， 神经学、心理学、信息学和计算机科学，谁将监督一个专门的研究人员 与研究密切合作，执行MRI和PET采集、数据处理和分析 项目。成像核心将协助各个项目优化每一种成像措施，以用于特定的 分析。

SUMMARY: CORE C- IMAGING CORE The Imaging Core supports the Harvard Aging Brain Study (HABS) Program Project Grant (PPG) by overseeing the acquisition and analyses of all imaging protocols. For the renewal, the Imaging Core will have primary responsibility for the acquisition of the PET protocols for both 11C Pittsburgh Compound B (PiB) and 18F Flortaucipir (FTP). The Core will be responsible for acquisition and analytic processing of the BASE MRI sequences to generate standard volumetric MRI variables for all HABS participants, including sampling of PET in MRI-defined regions-of-interest (ROI). The Core will provide BASE protocol image data for use with the ADVANCED Imaging protocol (Project 3), which includes FDG, R1, and TARP. All Core image data will be integrated with data from Core B: Clinical Core within the DataCentral database with oversight by Core D: Analytic Core. In conjunction with the Analytic Core, personnel from each of Projects 1 through 4 will be able to query the database to acquire fully quality-controlled image data for use in testing individual Project hypotheses. For the primary assessments of amyloid and tau deposition, the Core will provide a standard full dynamic protocol for PiB PET and a standard late-frame protocol for FTP PET (Aim 1). The BASE MRI protocol will consist of a standardized set of structural and functional acquisitions for subject characterization, including subcortical volumetrics, e.g., hippocampus, and cortical thickness (Aim 1). Standard measures derived from these data sets by the Core will be used by all four Projects to accomplish individual Project aims (Aim 2). These include proxy measures of amyloid and tau realized as PET metrics in individual or aggregated tissue ROI, e.g., global amyloid burden represented as PiB distribution volume ratio (DVR), or regional tau burden represented as inferior temporal FTP standardized uptake ratio (SUVr). The processing pipelines have been automated using a combination of tools based on FreeSurfer, SPM12, FSL, and in-house scripts and programs. The Imaging Core will supply the four PPG Projects with quality-checked MRI and PET ROI data that has been archived and managed under the supervision of the Analytic Core. The Imaging Core is composed of a strong group of clinical neuroimaging investigators, with specialized training in radiology, neurology, psychology, informatics, and computer science, who will supervise a dedicated research staff to perform MRI and PET acquisitions, data processing, and analyses in close collaboration with the research Projects. The Imaging Core will assist individual Projects to optimize each imaging measure for use in specific analyses.