High Sensitivity Diffuse Optical Tomography of Human Brain Funciton
人脑功能的高灵敏度漫反射光学断层扫描
基本信息
- 批准号:10542802
- 负责人:
- 金额:$ 54万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-08-01 至 2025-11-30
- 项目状态:未结题
- 来源:
- 关键词:AcuteAlgorithmsAnatomyBiological AssayBloodBlood flowBrainBrain imagingBrain regionCalibrationCaringCarotid ArteriesCephalicCerebrovascular CirculationCerebrumClinicalDataDevelopmentDiameterDiffuseDiffusionEdemaEventEvolutionFiberFunctional Magnetic Resonance ImagingGrantHeadHemoglobinHemorrhageHomeostasisHourHumanImageImpairmentInfarctionIntracranial PressureIschemiaIschemic StrokeLaser-Doppler FlowmetryLasersLightMagnetic Resonance ImagingMapsMeasurementMeasuresMethodsModalityModelingModernizationMonitorMorphologic artifactsMotionNear-Infrared SpectroscopyNeurologyNoiseOptical TomographyOpticsPatientsPatternPerfusionPhotic StimulationPhotonsPositron-Emission TomographyPremature BirthRattusResearchResolutionScalp structureSignal TransductionSourceSpecificitySpectrum AnalysisSpeedSystemTechnical ExpertiseTechniquesTimeTissuesTranslatingTraumatic Brain InjuryWorkacute strokearterial spin labelingartery occlusioncerebrovascularcraniumdata qualitydensitydetectordiffuse optical tomographyexperiencefunctional near infrared spectroscopyhypoxic ischemic injuryimaging approachimaging modalityimprintimprovedin vivoindexinginstrumentationmeterneuroimagingoptical imagingpost strokereconstructionrespiratory challengesensorspatiotemporalstatisticsstroke patienttomography
项目摘要
Project Summary:
This grant will develop speckle contrast optical tomography (SCOT) for imaging of cerebral blood flow
dynamics in humans. Real-time maps of cerebral blood flow (CBF) at the bedside are a long sought-after
assay for neuro-critical care. Most critically, regional CBF measures can indicate which brain regions
may be becoming ischemic and are at danger for hypoxic-ischemic injury. Current clinical methods for
imaging CBF include positron emission tomography (PET) and arterial spin labeling with Magnetic
Resonance Imaging (ASL- MRI). Both modalities provide only snapshots of CBF, though, thus they miss
dynamic events, which are important in many clinical scenarios including acute stroke, traumatic brain
injury, and preterm birth. Non-invasive optical techniques are an attractive approach for imaging brain
blood dynamics at the bedside. The most widely used non-invasive optical neuroimaging technique uses
near infrared spectroscopy (NIRS) to measure fluctuations in hemoglobin concentrations. Over the last
decade high-density diffuse optical tomography (HD-DOT) systems have made significant advances in
resolution and brain specificity making it an increasingly viable surrogate for functional MRI. However,
fNIRS and HD-DOT do not measure flow directly. Separately, there have been considerable advances in
laser speckle methods for measuring CBF. The most established deep tissue speckle method, diffuse
correlation spectroscopy (DCS), has been developed for in vivo tomographic imaging in rat models of
focal ischemia and for monitoring brain perfusion in humans.
However, in humans DCS has been limited to few spatial measurements, which precludes tomographic
imaging, and by instrumentation that permits only very low signal-to-noise ratio (SNR) measurements.
This proposal will address these limitations and develop speckle contrast optical tomography (SCOT), a
new method for transcranial optical imaging of relative CBF in humans. SCOT allows for the use of lower
speed detectors that could readily be implemented in parallel in modern scientific CMOS cameras. Aim 1
will develop SCOT instrumentation with high-density imaging arrays. Aim 2 will develop anatomically
derived head models for reconstructing SCOT images. Aim 3 will validate SCOT-based measures in
patients with carotid artery occlusions based on comparison to PET and ASL-MRI. Aim 4 will evaluate
the longitudinal feasibility of using SCOT for imaging acute stroke. These studies will represent the
culmination of several advances in functional neuroimaging made possible by the research teams’
unique combination of clinical and technical expertise across the domains of neurology, functional
neuroimaging and biomedical optics.
项目概要:
该基金将用于开发用于脑血流成像的斑点对比光学断层扫描(SCOT
人类的动力学长期以来,床旁脑血流(CBF)的实时图一直是人们所追求的。
用于神经重症监护。最关键的是,区域CBF测量可以指示哪些大脑区域
可能变得缺血,并处于缺氧缺血性损伤的危险中。当前的临床方法
成像CBF包括正电子发射断层扫描(PET)和动脉自旋标记与磁
共振成像(ASL-MRI)。然而,这两种模式都只提供了CBF的快照,因此它们错过了
动态事件,其在许多临床情况中是重要的,包括急性中风、创伤性脑损伤、
损伤和早产。无创光学技术是一种有吸引力的脑成像方法
血液动力学检查最广泛使用的非侵入性光学神经成像技术使用
近红外光谱(NIRS)测量血红蛋白浓度的波动。在过去
十年来,高密度漫射光学层析成像(HD-DOT)系统在以下方面取得了重大进展:
分辨率和大脑特异性使其成为功能性MRI越来越可行的替代品。然而,在这方面,
fNIRS和HD-DOT不直接测量流量。另外,在以下方面也取得了相当大的进展:
激光散斑法测量CBF。最成熟的深层组织散斑方法,扩散
相关光谱(DCS),已开发用于在体内断层成像的大鼠模型,
局灶性缺血和用于监测人脑灌注。
然而,在人类中,DCS仅限于很少的空间测量,这排除了断层扫描。
成像,以及通过仅允许非常低的信噪比(SNR)测量的仪器。
这项建议将解决这些限制,并开发斑点对比光学断层扫描(SCOT),
一种新的经颅光学成像方法,用于人类相对CBF的成像。SCOT允许使用较低的
速度检测器,可以很容易地实现在现代科学CMOS相机并行。要求1
将开发具有高密度成像阵列的SCOT仪器。目标2将在解剖学上发展
用于重建SCOT图像的导出的头部模型。目标3将验证基于SCOT的措施,
基于与PET和ASL-MRI的比较的颈动脉闭塞患者。目标4将评估
SCOT用于急性卒中成像的纵向可行性。这些研究将代表
研究小组在功能性神经成像方面取得的几项进展的高潮,
独特的临床和技术专长的结合,横跨神经病学,功能,
神经成像和生物医学光学。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(1)
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JOSEPH P CULVER其他文献
JOSEPH P CULVER的其他文献
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{{ truncateString('JOSEPH P CULVER', 18)}}的其他基金
Naturalistic Brain Mapping in Children with Diffuse Optical Tomography
利用漫射光学断层扫描对儿童进行自然脑图绘制
- 批准号:
10720660 - 财政年份:2023
- 资助金额:
$ 54万 - 项目类别:
Cortical Network Modulation by Subthalamic Nucleus Deep Brain Stimulation
丘脑底核深部脑刺激的皮质网络调节
- 批准号:
10220160 - 财政年份:2019
- 资助金额:
$ 54万 - 项目类别:
Cortical Network Modulation by Subthalamic Nucleus Deep Brain Stimulation
丘脑底核深部脑刺激的皮质网络调节
- 批准号:
10452517 - 财政年份:2019
- 资助金额:
$ 54万 - 项目类别:
Cortical Network Modulation by Subthalamic Nucleus Deep Brain Stimulation
丘脑底核深部脑刺激的皮质网络调节
- 批准号:
9817262 - 财政年份:2019
- 资助金额:
$ 54万 - 项目类别:
Cortical Network Modulation by Subthalamic Nucleus Deep Brain Stimulation
丘脑底核深部脑刺激的皮质网络调节
- 批准号:
10009477 - 财政年份:2019
- 资助金额:
$ 54万 - 项目类别:
Wireless High-Density Diffuse Optical Tomography for Decoding Brain Activity
用于解码大脑活动的无线高密度漫射光学断层扫描
- 批准号:
10244979 - 财政年份:2018
- 资助金额:
$ 54万 - 项目类别:
Wireless High-Density Diffuse Optical Tomography for Decoding Brain Activity
用于解码大脑活动的无线高密度漫射光学断层扫描
- 批准号:
10000137 - 财政年份:2018
- 资助金额:
$ 54万 - 项目类别:
HIGH-DENSITY OPTICAL TOMOGRAPHY IN PATIENTS WITH COCHLEAR IMPLANTS
人工耳蜗患者的高密度光学断层扫描
- 批准号:
9755396 - 财政年份:2018
- 资助金额:
$ 54万 - 项目类别:
Wireless High-Density Diffuse Optical Tomography for Decoding Brain Activity
用于解码大脑活动的无线高密度漫射光学断层扫描
- 批准号:
9791172 - 财政年份:2018
- 资助金额:
$ 54万 - 项目类别:
MAPPING FUNCTIONAL CONNECTIVITY WITH FLUORESCENCE MOLECULAR TOMOGRAPHY
使用荧光分子断层扫描绘制功能连接图
- 批准号:
10160971 - 财政年份:2017
- 资助金额:
$ 54万 - 项目类别:
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