Wireless High-Density Diffuse Optical Tomography for Decoding Brain Activity

用于解码大脑活动的无线高密度漫射光学断层扫描

• 批准号: 10244979
• 负责人: JOSEPH P CULVER
• 金额: $ 65.27万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-24 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10244979
• 关键词: 5 year old; Activities of Daily Living; Address; Adult; Affect; Algorithms; Architecture; Atlases; Attention; Auditory; Brain; Brain Mapping; Cerebral Palsy; Child; Childhood; Classification; Clinical; Cognitive; Coupled; Data; Data Set; Detection; Development; Diagnostic; Disease; Dorsal; Dyskinetic syndrome; Engineering; Family member; Fiber; Floor; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Grant; Head; Health; Image; In Situ; Individual; Infant; Intelligence; Language; Learning; Lighting; Locked-In Syndrome; Logistics; Magnetic Resonance Imaging; Maps; Modeling; Morphologic artifacts; Motion; Motor; Movement; Movement Disorders; Near-Infrared Spectroscopy; Noise; Optics; Patients; Performance; Population; Protocols documentation; Reporting; Resolution; Rest; Sensory; Software Tools; Stimulus; System; Techniques; Technology; Testing; Visual; Wireless Technology; Work; age group; aged; base; care providers; cognitive capacity; cognitive neuroscience; convolutional neural network; cortex mapping; density; design; detection sensitivity; detector; diffuse optical tomography; flexibility; improved; instrument; instrumentation; light weight; motor disorder; motor impairment; movie; neuroimaging; novel; optical imaging; pediatric patients; photonics; prevent; prognostic tool; response; spasticity; tomography; tool; visual motor; voluntary movement disorder

Project Summary This grant will develop a wireless wearable high-performance, high-density diffuse optical tomography (DOT) instrument for mapping of brain function in naturalistic settings. Functional neuroimaging of healthy adults has enabled mapping of brain function and revolutionized cognitive neuroscience. Increasingly, functional neuroimaging is being used in younger age groups, and as a diagnostic and prognostic tool in the clinical setting. Its expanding application in the study of both health and disease necessitates new, more flexible tools. The logistics of traditional functional brain scanners (e.g., fMRI) are ill-suited to many subjects. In particular, fMRI is not suited for imaging subjects who cannot lie sufficiently still in MRI scanners. In addition to young children (i.e. under 5 years old) in general, this requirement also excludes children with disorders of voluntary movement, such as moderate to severe cerebral palsy. A majority of patients with CP have either spasticity and/or dyskinesia, movement disorders that prohibits successful fMRI due to motion artifacts. A subset of CP subjects can be considered to have effectively a pediatric form of a “locked-in-syndrome”, in the sense that, while intelligence can be spared entirely, motor system dysfunction prevents the ability to speak or sign. Not uncommonly, the intellectual capacities of these children are never recognized by care-providers, educators, and family members. Thus, there are many intriguing questions in the CP population that could be addressed with functional neuroimaging, such as questions of motor plasticity and learning, perhaps the most compelling is identifying and characterizing the cognitive and neuroanatomical architecture of children with CP who are locked in. Such work could provide a path to unlocking the cognitive capacities of children with severe motor dysfunction. These studies cannot be done with fMRI. Optical imaging has long held promise as a naturalistic neuroimaging technique. Recent development of high- density diffuse optical tomography (HD-DOT), a tomographic version of fNIRS, has improved image quality dramatically. When matched within subjects against fMRI, HD-DOT now can obtain localization errors <5mm, and point spread functions <15 mm FWHM, sufficient to localize functions to gyri. While initial HD-DOT reports have been confined to simpler sensory networks (visual and motor), recent results demonstrate the feasibility of mapping distributed cognitive networks, including the dorsal attention and default mode networks. Despite these advances, application of HD-DOT to naturalistic studies has been limited by a barrier imposed by a tradeoff between coverage and wear-ability. The central photonic challenges are optical sensitivity - which would bias design towards larger/heavier fibers, and coverage - which would bias design towards a larger number of fibers. In this proposal, Aims 1-2 address the technological challenges of developing a lightweight wireless HD-DOT(WHD-DOT) system. Aim 3 develops the functional neuroimaging paradigms needed to map and decode brain function with WHD-DOT. In Aim 4, we assess the feasibility of mapping and decoding pediatric patients with cerebral palsy using WHD-DOT.

Project Summary This grant will develop a wireless wearable high-performance, high-density diffuse optical tomography (DOT) instrument for mapping of brain function in naturalistic settings. Functional neuroimaging of healthy adults has enabled mapping of brain function and revolutionized cognitive neuroscience. Increasingly, functional neuroimaging is being used in younger age groups, and as a diagnostic and prognostic tool in the clinical setting. Its expanding application in the study of both health and disease necessitates new, more flexible tools. The logistics of traditional functional brain scanners (e.g., fMRI) are ill-suited to many subjects. In particular, fMRI is not suited for imaging subjects who cannot lie sufficiently still in MRI scanners. In addition to young children (i.e. under 5 years old) in general, this requirement also excludes children with disorders of voluntary movement, such as moderate to severe cerebral palsy. A majority of patients with CP have either spasticity and/or dyskinesia, movement disorders that prohibits successful fMRI due to motion artifacts. A subset of CP subjects can be considered to have effectively a pediatric form of a “locked-in-syndrome”, in the sense that, while intelligence can be spared entirely, motor system dysfunction prevents the ability to speak or sign. Not uncommonly, the intellectual capacities of these children are never recognized by care-providers, educators, and family members. Thus, there are many intriguing questions in the CP population that could be addressed with functional neuroimaging, such as questions of motor plasticity and learning, perhaps the most compelling is identifying and characterizing the cognitive and neuroanatomical architecture of children with CP who are locked in. Such work could provide a path to unlocking the cognitive capacities of children with severe motor dysfunction. These studies cannot be done with fMRI. Optical imaging has long held promise as a naturalistic neuroimaging technique. Recent development of high- density diffuse optical tomography (HD-DOT), a tomographic version of fNIRS, has improved image quality dramatically. When matched within subjects against fMRI, HD-DOT now can obtain localization errors <5mm, and point spread functions <15 mm FWHM, sufficient to localize functions to gyri. While initial HD-DOT reports have been confined to simpler sensory networks (visual and motor), recent results demonstrate the feasibility of mapping distributed cognitive networks, including the dorsal attention and default mode networks. Despite these advances, application of HD-DOT to naturalistic studies has been limited by a barrier imposed by a tradeoff between coverage and wear-ability. The central photonic challenges are optical sensitivity - which would bias design towards larger/heavier fibers, and coverage - which would bias design towards a larger number of fibers. In this proposal, Aims 1-2 address the technological challenges of developing a lightweight wireless HD-DOT(WHD-DOT) system. Aim 3 develops the functional neuroimaging paradigms needed to map and decode brain function with WHD-DOT. In Aim 4, we assess the feasibility of mapping and decoding pediatric patients with cerebral palsy using WHD-DOT.

项目成果

Decoding visual information from high-density diffuse optical tomography neuroimaging data.

• DOI: 10.1016/j.neuroimage.2020.117516
• 发表时间: 2021-02-01
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Tripathy K;Markow ZE;Fishell AK;Sherafati A;Burns-Yocum TM;Schroeder ML;Svoboda AM;Eggebrecht AT;Anastasio MA;Schlaggar BL;Culver JP
• 通讯作者: Culver JP

Global motion detection and censoring in high-density diffuse optical tomography.

• DOI: 10.1002/hbm.25111
• 发表时间: 2020-10-01
• 期刊: Human brain mapping
• 影响因子: 4.8
• 作者: Sherafati A;Snyder AZ;Eggebrecht AT;Bergonzi KM;Burns-Yocum TM;Lugar HM;Ferradal SL;Robichaux-Viehoever A;Smyser CD;Palanca BJ;Hershey T;Culver JP
• 通讯作者: Culver JP

Optical imaging and spectroscopy for the study of the human brain: status report.

• DOI: 10.1117/1.nph.9.s2.s24001
• 发表时间: 2022-08
• 期刊: Neurophotonics
• 影响因子: 5.3