Scientific Core

科学核心

• 批准号: 10542742
• 负责人: Maria Acena Nagel
• 金额: $ 26.16万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10542742
• 关键词: Bioinformatics; Clinical; Colorado; Computers; Contract Services; Data; Data Analyses; Disease; Elderly; Ensure; Equipment; Equipment and Supplies; Foundations; Funding; Gene Expression Profiling; Goals; Grant; Herpesvirus Type 3; Human; Human Resources; Inflammation; Institutional Review Boards; Investigation; Laboratory Personnel; Maintenance; Monkeys; Process; Publications; Specimen; System; Tissues; Vision; computerized; cost; editorial; human tissue; laboratory experience; organizational structure; programs; repaired; tissue culture; transcriptome sequencing

The Scientific Core provides an organizational structure for scientific efforts common to all projects within the program to achieve the overall goals and vision of the Program Project as an integrated investigation in diseases caused by VZV in the elderly. The Core Leader, Dr. Maria Nagel, meets with the Clinical Coordinator daily to prioritize scientific efforts on all human and monkey specimens and to plan strategies and evaluate data. The Scientific Core provides support for the Clinical Coordinator, who will acquire, bank, process and computerize all tissue from humans in Projects 1 and 2 and from monkeys in Project 3, as well as ensure compliance with regulatory bodies including the Colorado Multiple Institutional Review Board. The Scientific Core also provides support in all 3 projects for: a bioinformatics expert to assist with RNA sequencing, data analysis and interpretation, and training of laboratory personnel in these analyses; a statistical consultant; an editorial consultant and publication costs; common-use supplies and equipment for tissue culture, PCR and gene expression profiling/RNA sequencing; and continuing service contracts, maintenance and repair of heavy equipment and computer costs.

科学核心为科学工作提供了一个组织结构，所有项目都在 计划以实现计划项目的总体目标和愿景，作为一项综合调查 VZV在老年人中引起的疾病。核心领导玛丽亚·内格尔博士会见临床协调员 每天对所有人类和猴子标本的科学工作进行优先排序，并计划战略和评估 数据。科学核心为临床协调员提供支持，临床协调员将获得、银行、流程和 将项目1和2中来自人类的所有组织以及项目3中来自猴子的所有组织计算机化，并确保 遵守包括科罗拉多州多机构审查委员会在内的监管机构。《科学》 CORE还在所有3个项目中提供支持：一名生物信息学专家协助RNA测序、数据 分析和解释以及在这些分析方面培训实验室人员；一名统计顾问；一名 编辑顾问和出版费用；组织培养、聚合酶链式反应和组织培养的常用用品和设备 基因表达谱分析/RNA测序；以及持续服务合同、维护和维修重型 设备和计算机成本。