Colorado Clinical and Transational Sciences Institute

由NIH在2008和2013年资助的科罗拉多州临床和翻译科学研究所(CCTSI)在 科罗拉多大学丹佛分校(CU-D)已经采取了令人印象深刻的步骤来改造和改进生物医学； 科罗拉多地区的研究和培训企业，并加速和催化翻译 在改善病人护理和公共卫生方面的发现。CCTSI是CU-D、CU Boulder(CU- B)、科罗拉多州立大学(CSU)、六家医院和20个社区组织建立了新的 基础设施，简化程序，并扩大现有资源和服务的调查员和 利益相关者；将支持开发翻译的培训和教育计划的数量增加了两倍 行政集中和扩大临床研究能力和专业知识的广度； 建立全系统信息学能力；促进团队科学和跨学科研究； 建立了广泛的社区参与计划，并加强了整个生命周期的研究； 简化了试验流程并缩短了启动时间；为临床和翻译创建了学术之家 科学家和受训人员；并积极参与CTSA网络活动。尽管取得了这些成功，但仍有 加快地方和国家翻译研究进程的许多挑战。此应用程序 规划了我们迎接这些挑战的前进道路。到2018年CTSA资金，我们将开发新的方法， 创新、专业知识和程序，以：a)在培训中达到可衡量的新水平 翻译团队，b)提高全方位翻译研究的效率和质量，c)促进 多点临床试验，d)让区域社区和利益攸关方成为合作伙伴，以及e)合作和 将最佳做法传播到国家CTSA联盟，以加快将发现转化为 改善健康和病人护理。我们将通过以下五个方面总体实现这些目标 战略目标：目标1：培养、教育和维持一支多样化的翻译科学队伍，以确保 最高的研究创新、质量和安全。目标2：创造一种翻译研究环境， 促进、支持和重视地方和国家的团队科学和协作。目标3：参与 地方和国家社区和利益攸关方参与翻译研究过程的所有阶段。目标4： 创建新的方法和资源，以支持和整合特殊人群的研究，包括 儿童、老年人、服务不足的人和患有罕见疾病的人。目标5：进一步创新精简 我们的流程，并增强我们在研究启动、实施和监督方面的信息学能力 促进我们研究的质量、效率和安全，并积极参与国家CTSA试验 创新网络。我们会作出特别努力，加强工作人口的多元化。我们的进展将是 由我们的评估核心监控，我们将根据需要进行中期更正以实现这些目标 并最终改善我们州和民族的健康。

Funded by NIH in 2008 and 2013, the Colorado Clinical and Translational Sciences Institute (CCTSI) at the University of Colorado Denver (CU-D) has taken impressive steps to transform and improve the biomedical; research and training enterprise in the Colorado region and to accelerate and catalyze the translation of discoveries into improved patient care and public health. The CCTSI, a partnership of CU-D, CU Boulder (CU- B), Colorado State University (CSU), six hospitals and 20 community organizations, has established new infrastructure, streamlined processes and expanded existing resources and services for investigators and stakeholders; tripled the number of training and education programs supporting development of a translational workforce; administratively centralized and expanded the breadth of clinical research capacity and expertise; established system-wide informatics capabilities; promoted team science and interdisciplinary research; established an extensive community engagement program and enhanced research across the lifespan; streamlined processes and reduced start-up times for trials; created an academic home for clinical & translational scientists and trainees; and actively engaged in CTSA network activities. Despite these successes, there remain many challenges to accelerating the translational research process locally and nationally. This application maps our path forward to meet these challenges. Through 2018 CTSA funding, we will develop new methods, innovations, expertise, and procedures to: a) achieve a new level of measurable performance in training translational teams, b) improve efficiency and quality of the full spectrum of translational research, c) facilitate multi-site clinical trials, d) engage regional communities and stakeholders as partners, and e) collaborate and disseminate best practices into the national CTSA consortium to accelerate the translation of discoveries into improved health and patient care. We will accomplish these objectives by embracing the following five Overall Strategic Goals: Goal 1: Develop, educate and sustain a diverse translational science workforce to ensure highest research innovation, quality and safety. Goal 2: Create a translational research environment in which team science and collaboration both locally and nationally are facilitated, supported and valued. Goal 3: Engage local and national communities and stakeholders in all phases of the translational research process. Goal 4: Create novel methodologies and resources to support and integrate research in special populations, including children, the elderly, the underserved and those with rare diseases. Goal 5: Further innovate and streamline our processes and enhance our informatics capacity for research start-up, implementation and oversight to promote quality, efficiency, & safety of our research and our active participation in the national CTSA Trial Innovation Network. Special efforts will be made to enhance diversity in our workforce. Our progress will be monitored by our Evaluation Core and we will make mid-course corrections as needed to achieve these goals and ultimately improve the health of our state and the nation.