Colorado Clinical and Transational Sciences Institute

科罗拉多临床和转化科学研究所

• 批准号: 9926131
• 负责人: RONALD J. SOKOL
• 金额: $ 792.72万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9926131
• 关键词: Biomedical Research; Child; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Colorado; Communities; Development; Elderly; Ensure; Environment; Evaluation; Funding; Goals; Health; Healthcare; Home environment; Hospitals; Informatics; Infrastructure; Institutes; Interdisciplinary Study; Longevity; Maps; Measurable; Methodology; Methods; Monitor; Multi-Institutional Clinical Trial; Participant; Patient Care; Patients; Performance; Phase; Procedures; Process; Public Health; Rare Diseases; Research; Research Personnel; Research Training; Resources; Safety; Science; Services; System; Time; Training; Training and Education; Translating; Translational Research; Translations; United States National Institutes of Health; Universities; community organizations; cost effective; effective therapy; improved; innovation; named group; next generation; novel; programs; success; translational pipeline; translational scientist

Funded by NIH in 2008 and 2013, the Colorado Clinical and Translational Sciences Institute (CCTSI) at the University of Colorado Denver (CU-D) has taken impressive steps to transform and improve the biomedical; research and training enterprise in the Colorado region and to accelerate and catalyze the translation of discoveries into improved patient care and public health. The CCTSI, a partnership of CU-D, CU Boulder (CU- B), Colorado State University (CSU), six hospitals and 20 community organizations, has established new infrastructure, streamlined processes and expanded existing resources and services for investigators and stakeholders; tripled the number of training and education programs supporting development of a translational workforce; administratively centralized and expanded the breadth of clinical research capacity and expertise; established system-wide informatics capabilities; promoted team science and interdisciplinary research; established an extensive community engagement program and enhanced research across the lifespan; streamlined processes and reduced start-up times for trials; created an academic home for clinical & translational scientists and trainees; and actively engaged in CTSA network activities. Despite these successes, there remain many challenges to accelerating the translational research process locally and nationally. This application maps our path forward to meet these challenges. Through 2018 CTSA funding, we will develop new methods, innovations, expertise, and procedures to: a) achieve a new level of measurable performance in training translational teams, b) improve efficiency and quality of the full spectrum of translational research, c) facilitate multi-site clinical trials, d) engage regional communities and stakeholders as partners, and e) collaborate and disseminate best practices into the national CTSA consortium to accelerate the translation of discoveries into improved health and patient care. We will accomplish these objectives by embracing the following five Overall Strategic Goals: Goal 1: Develop, educate and sustain a diverse translational science workforce to ensure highest research innovation, quality and safety. Goal 2: Create a translational research environment in which team science and collaboration both locally and nationally are facilitated, supported and valued. Goal 3: Engage local and national communities and stakeholders in all phases of the translational research process. Goal 4: Create novel methodologies and resources to support and integrate research in special populations, including children, the elderly, the underserved and those with rare diseases. Goal 5: Further innovate and streamline our processes and enhance our informatics capacity for research start-up, implementation and oversight to promote quality, efficiency, & safety of our research and our active participation in the national CTSA Trial Innovation Network. Special efforts will be made to enhance diversity in our workforce. Our progress will be monitored by our Evaluation Core and we will make mid-course corrections as needed to achieve these goals and ultimately improve the health of our state and the nation.

由NIH于2008年和2013年资助，科罗拉多州的临床和转化科学研究所（CCTSI） 科罗拉多大学丹佛大学（CU-D）采取了令人印象深刻的步骤来改造和改善生物医学。 科罗拉多州地区的研究和培训企业，并加速和催化翻译 发现改善患者护理和公共卫生。 CCTSI，Cu-D，Cu Boulder的合作伙伴关系（Cu- B），科罗拉多州立大学（CSU），六家医院和20个社区组织，已建立了新的 基础架构，简化流程并扩展了针对调查人员和的现有资源和服务 利益相关者；支撑转化的发展的培训和教育计划的数量增加了两倍 劳动力；行政上集中和扩大临床研究能力和专业知识的广度； 建立的全系统信息学功能；促进了团队科学和跨学科研究； 建立了一项广泛的社区参与计划，并在整个生命周期内增强了研究； 简化的过程和减少了试验的启动时间；创建了临床和翻译的学术住所 科学家和学员；并积极从事CTSA网络活动。尽管取得了这些成功，但仍有 在当地和全国范围内加速转化研究过程的许多挑战。此应用程序 将我们前进的道路映射到应对这些挑战。在2018年CTSA资金之前，我们将开发新方法， 创新，专业知识和程序：a）在培训中实现新的可衡量绩效水平 翻译团队，b）提高转化研究的效率和质量，c）促进 多站点临床试验，d）与区域社区和利益相关者作为合作伙伴，以及e）合作和 将最佳实践传播到国家CTSA财团中，以加速发现的转化 改善了健康和患者护理。我们将通过拥抱以下五个总体来实现这些目标 战略目标：目标1：发展，教育和维持多样化的转化科学劳动力，以确保 最高的研究创新，质量和安全。目标2：创建一个翻译研究环境 团队科学和合作在本地和全国范围内都得到了促进，支持和重视。目标3：参与 在翻译研究过程的各个阶段，地方和民族社区和利益相关者。目标4： 创建新颖的方法和资源来支持和整合特殊人群的研究，包括 儿童，老年人，服务不足和患有罕见疾病的孩子。目标5：进一步创新和精简 我们的流程并增强了我们的研究创业，实施和监督的信息能力，以 促进我们研究的质量，效率和安全性以及我们积极参与国家CTSA试验 创新网络。将做出特别的努力来增强我们的员工多样性。我们的进步将是 受我们的评估核心监控，我们将根据需要进行中途校正以实现这些目标 并最终改善我们国家和国家的健康。