Role of the Decision-Making Reference Point in Cognition and Psychopathology

项目摘要 情绪障碍的特点是倾向于主观评价客观积极的 消极的结果。几乎所有标准决策模型的一个基本特征- 决策是这样一种观点，即任何选择的主观价值都是由一个人的内在价值塑造的。 期望，或“参考点”。使用行为决策任务， 了解人类的期望是如何设定的，这里提出测试假设， 情感情绪影响决策参考点-计算实例 我们的期望，从而驱动主观价值的变化，标志着情绪病理， 重度抑郁症（MDD）。在我们的第一个目标中，我们试图建立情绪与 健康选择者和情绪障碍者的参考点的静态， MDD，病理水平与容易和客观测量的参考点相关。 在第二个目标中，我们建议扩展这些工具，以关联动态参考率 情绪状态与抑郁症状在健康与病理状态下的穴位重置 人口。我们假设，开发一个神经计算框架， 理解精神病理学中参考点的作用可能会提供一个新的结构， 在RDoC框架中使用。

Project Summary Mood disorders are characterized by a tendency to subjectively evaluate objectively positive outcomes in a negative light. A fundamental feature of nearly all standard models of decision- making is the idea that the subjective value of any choice option is shaped by one’s internal expectation, or ‘reference point’. Using behavioral decision-making tasks informed by an understanding of how human expectations are set, here propose to test the hypothesis that affective mood impacts the decision-making reference point—the computational instantiation of our expectations—and thus drives shifts in subjective value that mark mood pathologies like major depressive disorder (MDD). In our first Aim we seek to establish that mood correlates with the static state of the reference point in health choosers and that in mood disorders, principally MDD, the level of pathology correlates with the easily and objectively measured reference point. In the second aim we propose to extend these tools to correlate the rate of dynamic reference point resetting with mood state and depressive symptoms in healthy and pathological populations. We hypothesize that developing a neurocomputational framework for understanding the role of the reference point in psychopathology may offer a new construct for use in the RDoC framework.