A pen side test for Schmallenberg virus exposure in sheep and cattle.

对绵羊和牛进行施马伦贝格病毒暴露的笔侧测试。

• 批准号: 101463
• 金额: $ 16.53万
• 依托单位: ADAS UK LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=101463
• 关键词: pen; side; test; Schmallenberg; virus

Since its emergence in 2011, Schmallenberg virus (SBV) has spread across most of the European continent. The virus causes a mild disease in adult sheep and cattle (fever, reduced milk yield and diarrhoea). However if an animal is infected during pregnancy, resultant offspring can have severe deformities. SBV is spread by biting midges making efforts to control it very difficult. The economic impact of SBV has been significant with some sheep farmers losing more than 30% of their lambs as well as lost milk production for dairy farmers. With a vaccine launch in the near future, control of SBV becomes possible, however farmers will have to make an economic decision as to whether the cost of vaccination outweighs the losses they are experiencing. This project will focus on developing cost-effective tests that can be used by farmers or vets to see whether animals are likely to be protected against infection. This information can be used to decide whether or not vaccination of some or all of the herd or flock is necessary. The tests will also be useful for confirming whether SBV is responsible for any deformed offspring before embarking on more expensive post mortem tests. This project will also produce information as to which parts of SBV stimulate a strong immune response. This is essential for developing refined vaccines and diagnostic tests. These tools will allow animals that have antibodies as a result of vaccination to be distinguished from animals that have been infected with SBV. This information will be vital for livestock exporters to regain access to markets outside of the EU that have implemented trade bans due to SBV. It will also allow monitoring of whether infection is occurring despite the use of vaccines.

自2011年出现以来，施马伦贝格病毒（SBV）已蔓延到欧洲大陆的大部分地区。该病毒在成年羊和牛中引起轻度疾病（发烧、产奶量减少和腹泻）。然而，如果动物在怀孕期间被感染，由此产生的后代可能会有严重的畸形。SBV通过叮咬蠓传播，因此很难控制它。SBV的经济影响是巨大的，一些养羊户损失了30%以上的羔羊，奶牛场的牛奶产量也因此减少。随着在不久的将来推出疫苗，控制SBV成为可能，但是农民将不得不做出经济决策，以确定疫苗接种的成本是否超过他们所遭受的损失。这个项目将侧重于开发具有成本效益的测试方法，农民或兽医可以使用这些测试方法来观察动物是否有可能免受感染。该信息可用于决定是否需要对部分或全部牛群或羊群接种疫苗。在进行更昂贵的尸检测试之前，这些测试还将有助于确认SBV是否导致了任何畸形的后代。该项目还将提供关于SBV的哪些部分刺激强烈免疫反应的信息。这对于开发精细疫苗和诊断测试至关重要。这些工具将使因接种疫苗而产生抗体的动物与已感染SBV的动物区分开来。这一信息对于牲畜出口商重新进入欧盟以外因SBV而实施贸易禁令的市场至关重要。它还将允许监测在使用疫苗的情况下是否发生感染。