Xavier RCMI Renewal Application-Research Infrastructure Core

研究基础设施核心概述 RCMI癌症研究中心旨在提高泽维尔基础生物医学的质量和生产力。 和行为研究的重点领域，癌症和癌症相关的健康差距，建立一个 研究基础设施核心（RIC）将共享仪器，药物发现和交付 程序，细胞和分子生物学设施，以及生物信息学服务。现有核心资源的基础是 前三个RCMI核心实验室为Xavier研究人员提供服务，并帮助扩大研究 能力在过去十年。基于对当前研究的优势和劣势的评估 Xavier调查员组合，RIC将实施新的优先级规则，修订和改进 标准化运作程序，以及更有效的核心设施管理，包括 跨学科专业知识和成本回收系统。RIC将最大限度地使Xavier研究人员受益 在所有与健康相关的研究领域，通过实现三个具体目标：目标1。获取、维护和 操作共享的分析和生物分析仪器，不仅用于基础生物医学， 研究项目和试点项目，以资助目前的RCMI申请，而且所有泽维尔 研究人员在广泛的健康相关的研究领域。RIC将提供必要的 Xavier生物医学研究项目的仪器和技术支持，这些项目依赖于 主要设备运行。目标2.形成一个教师专业小组（FEG），提供教师级的专业知识， 研究方法、专门实验室技术、统计、生物信息学和卫生信息学。的 FEG将由在实验设计和研究方面具有研究专长的高级教师组成 药物发现和配方、细胞和分子生物学、机制研究和数据策略 使用各种生物信息学和生物统计学工具处理药物发现、药物递送、细胞和分子 生物学、生物信息学和分析仪器。目标3.实施有效的成本回收计划， 研究基础设施核心。RIC将继续使用2012年开始的收费系统。FEG将 监督退款流程并维护账户余额。所收取的费用将继续用于 部分支付核心设施所需的消耗性部件费用和意外维修费用。 将采取额外措施，通过承保核心工作人员，增加核心设施的成本回收 Xavier研究人员在外部赠款申请方面的努力。

Summary of Research Infrastructure Core The RCMI Cancer Research Center aims to enhance the quality and productivity of Xavier’s basic biomedical and behavior research in the focus area of cancer and cancer-related health disparities by establishing a Research Infrastructure Core (RIC) that will have shared instrumentation, drug discovery and delivery programs, cell and molecular biology facilities, and bioinformatics services. The current core resources build on the previous three RCMI core laboratories that served Xavier investigators and helped expand the research capacity in the last decade. Based on the assessment of strengths and weaknesses in the current research portfolio of Xavier investigators, the RIC will implement new rules of prioritization, revised and improved standard operation procedures, and more effective management of core facilities including convergence of cross disciplinary expertise and cost recovery systems. The RIC will maximally benefit Xavier investigators across all health-related research areas by achieving three specific aims: Aim 1. Acquire, maintain, and operate shared analytical and bioanalytical instrumentation that will be utilized by not only the basic biomedical research projects and pilot projects to be funded by the current RCMI application, but also all Xavier investigators across a broad range of health-related research areas. The RIC will provide essential instrumental and technical support for Xavier’s biomedical research projects that rely on the availability of functioning major equipment. Aim 2. Form a faculty expertise group (FEG) to provide faculty-level expertise in research methodology, specialized laboratory techniques, statistics, bioinformatics and health informatics. The FEG will consist of senior faculty members with research expertise in experimental design and research strategy on drug discovery and formulation, cell and molecular biology, mechanistic investigations, and data processing using various bioinformatics and biostatistics tools drug discovery, drug delivery, cell and molecular biology, bioinformatics, and analytical instrumentation. Aim 3. Implement an effective cost recovery program for the Research Infrastructure Core. RIC will continue to use a fee charging system started in 2012. The FEG will oversee the charge back process and maintain account balance. The fees collected will continue to be used to partially defray the cost of consumable parts and unexpected repair costs needed for the core facilities. Additional measures will be implemented to increase cost recovery of core facilities by underwriting core staff efforts in external grant applications by Xavier investigators.