Xavier RCMI Renewal Application-Research Infrastructure Core

Xavier RCMI 更新应用研究基础设施核心

• 批准号: 10544048
• 负责人: Vladimir Kolesnichenko
• 金额: $ 116.67万
• 依托单位: XAVIER UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-24 至 2023-09-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10544048
• 关键词: Applications Grants; Area; Back; Behavior; Bioinformatics; Biomedical Research; Biometry; Cellular biology; Charge; Collaborations; Communities; Core Facility; Data; Development; Drug Delivery Systems; Drug Formulations; Electrophoresis; Equilibrium; Equipment; Experimental Designs; Faculty; Fees; Fees and Charges; Funding; Goals; Health; Institution; Institutionalization; Investigation; Joints; Laboratories; Malignant Neoplasms; Measures; Microscope; Molecular Biology; NCI Center for Cancer Research; Pilot Projects; Procedures; Process; Productivity; Public Health Informatics; Recovery; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Project Grants; Resources; Reverse Transcriptase Polymerase Chain Reaction; Services; Spectrophotometry; System; Techniques; Time; cancer health disparity; computerized data processing; cost; drug discovery; experimental study; improved; instrument; instrumentation; member; operation; programs; repaired; senior faculty; statistics; tool

Summary of Research Infrastructure Core The RCMI Cancer Research Center aims to enhance the quality and productivity of Xavier’s basic biomedical and behavior research in the focus area of cancer and cancer-related health disparities by establishing a Research Infrastructure Core (RIC) that will have shared instrumentation, drug discovery and delivery programs, cell and molecular biology facilities, and bioinformatics services. The current core resources build on the previous three RCMI core laboratories that served Xavier investigators and helped expand the research capacity in the last decade. Based on the assessment of strengths and weaknesses in the current research portfolio of Xavier investigators, the RIC will implement new rules of prioritization, revised and improved standard operation procedures, and more effective management of core facilities including convergence of cross disciplinary expertise and cost recovery systems. The RIC will maximally benefit Xavier investigators across all health-related research areas by achieving three specific aims: Aim 1. Acquire, maintain, and operate shared analytical and bioanalytical instrumentation that will be utilized by not only the basic biomedical research projects and pilot projects to be funded by the current RCMI application, but also all Xavier investigators across a broad range of health-related research areas. The RIC will provide essential instrumental and technical support for Xavier’s biomedical research projects that rely on the availability of functioning major equipment. Aim 2. Form a faculty expertise group (FEG) to provide faculty-level expertise in research methodology, specialized laboratory techniques, statistics, bioinformatics and health informatics. The FEG will consist of senior faculty members with research expertise in experimental design and research strategy on drug discovery and formulation, cell and molecular biology, mechanistic investigations, and data processing using various bioinformatics and biostatistics tools drug discovery, drug delivery, cell and molecular biology, bioinformatics, and analytical instrumentation. Aim 3. Implement an effective cost recovery program for the Research Infrastructure Core. RIC will continue to use a fee charging system started in 2012. The FEG will oversee the charge back process and maintain account balance. The fees collected will continue to be used to partially defray the cost of consumable parts and unexpected repair costs needed for the core facilities. Additional measures will be implemented to increase cost recovery of core facilities by underwriting core staff efforts in external grant applications by Xavier investigators.

研究基础设施核心摘要 RCMI癌症研究中心旨在提高Xavier基础生物医学的质量和生产力 通过建立一个癌症和癌症相关健康差异的重点领域的行为研究 研究基础设施核心 (RIC) 将共享仪器、药物发现和交付 计划、细胞和分子生物学设施以及生物信息学服务。目前的核心资源建立在 之前为 Xavier 研究人员提供服务并帮助扩大研究范围的三个 RCMI 核心实验室 过去十年的能力。基于对当前研究的优势和劣势的评估 Xavier 研究人员的投资组合，RIC 将实施新的优先顺序规则，并进行修订和改进 标准操作流程，以及更有效的核心设施管理，包括融合 跨学科的专业知识和成本回收系统。 RIC 将使 Xavier 调查人员最大程度受益 通过实现三个具体目标，跨越所有与健康相关的研究领域： 目标 1. 获取、维持和 操作共享的分析和生物分析仪器，这些仪器不仅可供基本生物医学领域使用 由当前 RCMI 申请资助的研究项目和试点项目，以及所有 Xavier 广泛的健康相关研究领域的研究人员。 RIC 将提供必要的 为泽维尔的生物医学研究项目提供仪器和技术支持，这些项目依赖于以下资源的可用性 主要设备正常运转。目标 2. 组建教师专业知识小组 (FEG)，提供以下领域的教师级专业知识 研究方法、专业实验室技术、统计学、生物信息学和健康信息学。这 FEG 将由在实验设计和研究方面具有研究专业知识的高级教师组成 药物发现和配方、细胞和分子生物学、机制研究和数据策略 使用各种生物信息学和生物统计学工具进行处理药物发现、药物递送、细胞和分子 生物学、生物信息学和分析仪器。目标 3. 实施有效的成本回收计划 研究基础设施核心。 RIC 将继续使用 2012 年开始的收费系统。FEG 将 监督退款流程并维护帐户余额。所收取的费用将继续用于 部分支付核心设施所需的易损件成本和意外维修费用。 将采取额外措施，通过承保核心员工来增加核心设施的成本回收 Xavier 研究人员在外部资助申请中的努力。