Xavier RCMI Renewal Application-Research Infrastructure Core

Xavier RCMI 更新应用研究基础设施核心

• 批准号: 10322699
• 负责人: Vladimir Kolesnichenko
• 金额: $ 83.92万
• 依托单位: XAVIER UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-24 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10322699
• 关键词: Applications Grants; Area; Back; Behavior; Bioinformatics; Biomedical Research; Biometry; Cellular biology; Charge; Communities; Consult; Core Facility; Data; Development; Drug Delivery Systems; Drug Formulations; Electrophoresis; Equilibrium; Equipment; Experimental Designs; Faculty; Fees; Fees and Charges; Funding; Goals; Health; Investigation; Joints; Laboratories; Lead; Malignant Neoplasms; Measures; Microscope; Molecular Biology; NCI Center for Cancer Research; Pilot Projects; Procedures; Process; Productivity; Public Health Informatics; Recovery; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Project Grants; Resources; Reverse Transcriptase Polymerase Chain Reaction; Services; Spectrophotometry; System; Techniques; Time; base; cancer health disparity; computerized data processing; cost; drug discovery; experimental study; improved; instrument; instrumentation; member; operation; programs; repaired; senior faculty; statistics; tool

Summary of Research Infrastructure Core The RCMI Cancer Research Center aims to enhance the quality and productivity of Xavier’s basic biomedical and behavior research in the focus area of cancer and cancer-related health disparities by establishing a Research Infrastructure Core (RIC) that will have shared instrumentation, drug discovery and delivery programs, cell and molecular biology facilities, and bioinformatics services. The current core resources build on the previous three RCMI core laboratories that served Xavier investigators and helped expand the research capacity in the last decade. Based on the assessment of strengths and weaknesses in the current research portfolio of Xavier investigators, the RIC will implement new rules of prioritization, revised and improved standard operation procedures, and more effective management of core facilities including convergence of cross disciplinary expertise and cost recovery systems. The RIC will maximally benefit Xavier investigators across all health-related research areas by achieving three specific aims: Aim 1. Acquire, maintain, and operate shared analytical and bioanalytical instrumentation that will be utilized by not only the basic biomedical research projects and pilot projects to be funded by the current RCMI application, but also all Xavier investigators across a broad range of health-related research areas. The RIC will provide essential instrumental and technical support for Xavier’s biomedical research projects that rely on the availability of functioning major equipment. Aim 2. Form a faculty expertise group (FEG) to provide faculty-level expertise in research methodology, specialized laboratory techniques, statistics, bioinformatics and health informatics. The FEG will consist of senior faculty members with research expertise in experimental design and research strategy on drug discovery and formulation, cell and molecular biology, mechanistic investigations, and data processing using various bioinformatics and biostatistics tools drug discovery, drug delivery, cell and molecular biology, bioinformatics, and analytical instrumentation. Aim 3. Implement an effective cost recovery program for the Research Infrastructure Core. RIC will continue to use a fee charging system started in 2012. The FEG will oversee the charge back process and maintain account balance. The fees collected will continue to be used to partially defray the cost of consumable parts and unexpected repair costs needed for the core facilities. Additional measures will be implemented to increase cost recovery of core facilities by underwriting core staff efforts in external grant applications by Xavier investigators.

研究基础设施核心概述 RCMI癌症研究中心旨在提高泽维尔基础生物医学的质量和生产率 在癌症和与癌症相关的健康差距的焦点领域进行行为研究，通过建立一个 将共享仪器、药物发现和交付的研究基础设施核心(RIC) 项目、细胞和分子生物学设施以及生物信息学服务。当前的核心资源建立在 前三个为泽维尔研究人员提供服务并帮助扩大研究范围的RCMI核心实验室 过去十年的产能。基于对当前研究中的优势和劣势的评估 泽维尔调查人员组合，RIC将实施新的优先顺序规则，并进行修订和改进 标准运作程序，以及更有效地管理核心设施，包括汇聚 跨学科专业知识和成本回收系统。RIC将最大限度地使泽维尔调查人员受益 通过实现三个具体目标跨越所有与健康相关的研究领域：目标1.获取、维护和 运行共享的分析和生物分析仪器，不仅将被基础生物医学使用 研究项目和试点项目将由目前的RCMI申请资助，但也都是Xavier 研究人员涉及与健康相关的广泛研究领域。RIC将提供必要的 为泽维尔的生物医学研究项目提供仪器和技术支持，这些项目依赖于 运行正常的主要设备。目标2.成立教员专家小组(FEG)，提供教员级别的专业知识 研究方法、专业实验室技术、统计学、生物信息学和卫生信息学。这个 FEG将由在实验设计和研究方面具有研究专长的高级教员组成 药物发现和配制战略、细胞和分子生物学、机制研究和数据 使用各种生物信息学和生物统计学工具处理药物发现、药物传递、细胞和分子 生物学、生物信息学和分析仪器。目标3.实施有效的成本回收计划 研究基础设施核心。RIC将继续使用2012年开始的收费系统。FEG将 监督退款流程，维护账户余额。所收取的费用将继续用于 支付部分易耗件费用和核心设施所需的意外维修费用。 将实施更多措施，通过为核心员工提供担保，增加核心设施的成本回收 泽维尔调查人员在外部赠款申请方面的努力。