Xavier RCMI Renewal Application-Research Infrastructure Core

Xavier RCMI 更新应用研究基础设施核心

• 批准号: 10078880
• 负责人: Vladimir Kolesnichenko
• 金额: $ 102.55万
• 依托单位: XAVIER UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-24 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10078880
• 关键词: Applications Grants; Area; Back; Behavior; Bioinformatics; Biomedical Research; Biometry; Cellular biology; Charge; Communities; Consult; Core Facility; Data; Development; Drug Delivery Systems; Drug Formulations; Electrophoresis; Equilibrium; Equipment; Experimental Designs; Faculty; Fees; Fees and Charges; Funding; Goals; Health; Investigation; Joints; Laboratories; Lead; Malignant Neoplasms; Measures; Microscope; Molecular Biology; NCI Center for Cancer Research; Pilot Projects; Procedures; Process; Productivity; Public Health Informatics; Recovery; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Project Grants; Resources; Reverse Transcriptase Polymerase Chain Reaction; Services; Spectrophotometry; System; Techniques; Time; base; cancer health disparity; computerized data processing; cost; drug discovery; experimental study; improved; instrument; instrumentation; member; operation; programs; repaired; senior faculty; statistics; tool

Summary of Research Infrastructure Core The RCMI Cancer Research Center aims to enhance the quality and productivity of Xavier’s basic biomedical and behavior research in the focus area of cancer and cancer-related health disparities by establishing a Research Infrastructure Core (RIC) that will have shared instrumentation, drug discovery and delivery programs, cell and molecular biology facilities, and bioinformatics services. The current core resources build on the previous three RCMI core laboratories that served Xavier investigators and helped expand the research capacity in the last decade. Based on the assessment of strengths and weaknesses in the current research portfolio of Xavier investigators, the RIC will implement new rules of prioritization, revised and improved standard operation procedures, and more effective management of core facilities including convergence of cross disciplinary expertise and cost recovery systems. The RIC will maximally benefit Xavier investigators across all health-related research areas by achieving three specific aims: Aim 1. Acquire, maintain, and operate shared analytical and bioanalytical instrumentation that will be utilized by not only the basic biomedical research projects and pilot projects to be funded by the current RCMI application, but also all Xavier investigators across a broad range of health-related research areas. The RIC will provide essential instrumental and technical support for Xavier’s biomedical research projects that rely on the availability of functioning major equipment. Aim 2. Form a faculty expertise group (FEG) to provide faculty-level expertise in research methodology, specialized laboratory techniques, statistics, bioinformatics and health informatics. The FEG will consist of senior faculty members with research expertise in experimental design and research strategy on drug discovery and formulation, cell and molecular biology, mechanistic investigations, and data processing using various bioinformatics and biostatistics tools drug discovery, drug delivery, cell and molecular biology, bioinformatics, and analytical instrumentation. Aim 3. Implement an effective cost recovery program for the Research Infrastructure Core. RIC will continue to use a fee charging system started in 2012. The FEG will oversee the charge back process and maintain account balance. The fees collected will continue to be used to partially defray the cost of consumable parts and unexpected repair costs needed for the core facilities. Additional measures will be implemented to increase cost recovery of core facilities by underwriting core staff efforts in external grant applications by Xavier investigators.

研究基础设施核心的摘要 RCMI癌症研究中心旨在提高Xavier基本生物医学的质量和生产力 以及通过建立癌症和癌症相关健康分布的重点领域的行为研究 研究基础设施核心（RIC）将共享仪器，药物发现和交付 程序，细胞和分子生物学设施以及生物信息学服务。当前的核心资源以 前三个RCMI核心实验室为Xavier调查人员提供服务并帮助扩大了研究 过去十年的能力。根据当前研究中的优势和劣势的评估 Xavier调查人员的投资组合，RIC将实施新的优先级规则，修订和改进 标准操作程序，以及对核心设施的更有效管理，包括 跨学科专业知识和成本恢复系统。 RIC将最大利益Xavier调查人员 在所有与健康相关的研究领域中 运营共享的分析和生物分析仪器，不仅将由基本生物医学使用 研究项目和试点项目将由当前的RCMI应用程序资助，但也是所有Xavier 各种与健康相关的研究领域的研究人员。 RIC将提供必不可少的 Xavier生物医学研究项目的工具和技术支持，这些项目依赖于可用性 运行主要设备。目标2。成立教师专业知识小组（FEG），以提供教师级专业知识 研究方法，专业实验室技术，统计，生物信息学和健康信息。这 FEG将由具有实验设计和研究研究专业知识的高级教师组成 药物发现和配方，细胞和分子生物学，机械研究以及数据的策略 使用各种生物信息学和生物统计学工具的加工药物发现，药物递送，细胞和分子 生物学，生物信息学和分析仪器。目标3。实施有效的成本恢复计划 研究基础设施核心。 RIC将继续使用2012年开始的费用充电系统。FEG将 监督收费流程并保持帐户余额。收集的感受将继续习惯 部分支付核心设施所需的消耗零件成本和意外维修成本。 将采取其他措施通过承保核心人员来提高核心设施的成本回收 Xavier调查人员在外部赠款申请中的努力。