Therapeutic ultrasound for treatment of hypothyroidism

治疗性超声治疗甲状腺功能减退症

• 批准号: 10551996
• 负责人: Vesna Zderic
• 金额: $ 8.08万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10551996
• 关键词: Adipocytes; Adrenal Glands; Affect; Apoptotic; Area; Biological Assay; Biological Sciences; Biomedical Engineering; Body Temperature; Body Weight; Breathing; CASP3 gene; Calcitonin; Catecholamines; Cattle; Cell Survival; Cell physiology; Cells; Chromaffin Cells; Clinical; Defect; Deficiency Diseases; Disease; Dose; Dyes; Elderly; Endocrine; Endocrine Glands; Endocrine System Diseases; Endocrine system; Endocrinologist; Endocrinology; Engineering; Enzyme-Linked Immunosorbent Assay; Event; Exclusion; Fluorescence; Fluorescence Microscopy; Generations; Goals; Heart Rate; Hormonal; Hormone replacement therapy; Hormones; Human; Hydrogen Peroxide; Hypothyroidism; In Vitro; Insulin; Measures; Medicine; Menstrual cycle; Metabolic Diseases; Metabolic hormone; Metabolism; Methods; Modeling; Modification; Molecular; Non-Insulin-Dependent Diabetes Mellitus; Organ; Pancreas; Pathology; Pathway interactions; Persons; Physiological; Population; Process; Publishing; Research; Research Personnel; Rodent; Role; Safety; Schools; Structure of beta Cell of islet; Structure of thyroid parafollicular cell; Testing; Therapeutic; Therapeutic Effect; Thyroid Gland; Thyroid Hormones; Thyrotropin-Releasing Hormone; Thyroxine; Time; Tissues; Triiodothyronine; Trypan Blue; Ultrasonic Therapy; United States; Universities; Washington; Woman; Work; adiponectin; combat; cytotoxic; effectiveness evaluation; effectiveness testing; human old age (65+); improved; in vitro Model; in vivo; interest; medical schools; men; novel; obese person; older patient; pharmacologic; programs; sodium ion; therapeutic target; treatment optimization; ultrasound

Project Abstract The thyroid gland is a regulatory organ within the endocrine system vital to many essential processes including breathing and heart rate, metabolism and body weight, menstrual cycles, and body temperature. Hypothyroidism is a common disease especially among the elderly, affecting 5–20% of women and 3–8% of men, and is on the rise in the United States. Thyroid hormone replacement therapy is used for treatment of hypothyroidism but suffers from various problems with therapy optimization and dose adjustment. Our main goal is to determine whether ultrasound can serve as a non-invasive and non-pharmacological method for treatment of hypothyroidism. Here, we propose a novel exploratory study to determine if and how ultrasound may stimulate and control thyroid gland function such as synthesis and release of metabolic hormones triiodothyronine (T3) and thyroxine (T4) in a physiologically relevant context. Our previous and ongoing research work has shown that low intensity therapeutic ultrasound releases insulin from pancreatic beta cells and rodent pancreas at physiological levels without compromising cell viability. This finding opens the doors for possible use of ultrasound therapy in ameliorating secretory defects in other endocrine diseases. The long-term goal of our collaborative research program among Schools of Engineering, Biological Sciences and Medicine at The George Washington University is to develop a mechanistic understanding of the role of therapeutic ultrasound in enhancing release of hormones as a potential treatment of various endocrine diseases. The main objective of this proposal is to determine whether and in what way ultrasound may impact release of thyroid hormones in an in vitro rodent thyroid gland model. Specific Aim 1 of this research work will focus on determining the effectiveness and safety of ultrasound stimulation of the thyroid gland for release of metabolic hormones with the hypothesis that ultrasound treatment promotes release of endocrine thyroid hormones T3 and T3 with little or no other secretory products being released. Specific Aim 2 will focus on determination of mechanisms of ultrasound impact on release of thyroid metabolic hormones with the hypothesis that the mechanism of ultrasound action on the release of thyroid metabolic hormones T3 and T4 is related to the transport of sodium ions and generation of hydrogen peroxide. If shown successful, our proposed approach may open new strategies to combat various endocrine and metabolic diseases.

项目摘要