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Neural and genetic mechanisms underlying behavior in C. elegans

线虫行为背后的神经和遗传机制

基本信息

批准号：
10551966
负责人：
Shawn Xu
金额：
$ 43.38万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-06-01 至 2028-05-31
项目状态：
未结题

项目摘要

Project Summary The long-term goal of our research is to understand how the sensory environment regulates animal behavior. In this proposal, we will focus on investigating the genetic and neural basis of two sensory modalities: thermosensation and osmosensation. The ability to sense temperature and osmolarity is essential for life. Defects in thermosensation and osmosensation cause various neurological, renal and metabolic disorders. A key player in thermosensation and osmosensation is the molecular sensory receptors that detect thermal and osmotic cues. However, the molecular identities of cold-sensing receptors that sense cold temperatures are poorly understood. Similarly, no osmolarity-sensing receptors have thus far been definitively identified in any metazoan organisms. C. elegans is a popular genetic model organism widely used for the study of sensory biology. To survive the harsh environment, C. elegans has evolved a rich repertoire of sensory systems. Like mammals, C. elegans possesses the sense of temperature and osmolarity. Here, we propose to investigate the genetic and neural mechanisms by which animals sense temperature, particularly cold temperature, as well as osmolarity using C. elegans as a model. To do so, we will take a multifaceted approach that integrates molecular genetics, behavioral analysis, laser ablation, whole-brain imaging, and electrophysiology. As the mechanisms underlying thermosensation and osmosensation, particularly those involving sensory receptors, tend to be evolutionarily conserved, the proposed work will provide novel insights into our understanding of thermosensation and osmosensation in humans and their related neurological, renal and metabolic disorders.

项目摘要我们研究的长期目标是了解感官环境如何调节动物行为。在这个建议中，我们将重点研究两种感觉方式的遗传和神经基础：热觉和热觉。感知温度和渗透压的能力对生命至关重要。温度感觉和体温感觉的缺陷会导致各种神经、肾脏和代谢疾病。一温度感觉和温度感觉的关键参与者是检测温度和温度的分子感觉受体。渗透暗示然而，感觉冷温度的冷感觉受体的分子身份是不太了解。类似地，到目前为止，在任何一种细胞中都没有明确鉴定出渗透压敏感受体。后生动物有机体。C.秀丽线虫是一种流行的遗传模式生物，广泛用于感觉器官的研究。生物学为了在恶劣的环境中生存，C。线虫进化出了丰富的感觉系统像 mammals，C.线虫具有温度感和渗透压感。在这里，我们建议调查动物感知温度的遗传和神经机制，特别是寒冷的温度，以及使用C.优雅的模特为此，我们将采取多方面的方法，分子遗传学、行为分析、激光消融、全脑成像和电生理学。为热感觉和热感觉的潜在机制，特别是涉及感觉受体的机制，往往是进化保守的，拟议的工作将提供新的见解，我们的理解人类的温度感觉和体温感觉及其相关的神经、肾脏和代谢紊乱。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

A cilia-independent function of BBSome mediated by DLK-MAPK signaling in C. elegans photosensation.

DOI：
10.1016/j.devcel.2022.05.005
发表时间：
2022-06-20
期刊：
DEVELOPMENTAL CELL
影响因子：
11.8
作者：
Zhang, Xinxing;Liu, Jinzhi;Pan, Tong;Ward, Alex;Liu, Jianfeng;Xu, X. Z. Shawn
通讯作者：
Xu, X. Z. Shawn

Identification of a cold sensor in peripheral somatosensory neurons.

外周体感神经元冷传感器的识别。