Temple Strategies to Innovate EmeRgENcy Care Clinical Trials Network (Temple-SIREN)

Temple 创新紧急护理临床试验网络的策略 (Temple-SIREN)

• 批准号: 10552436
• 负责人: NINA T GENTILE
• 金额: $ 40.91万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-15 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10552436
• 关键词: Academic Medical Centers; Accident and Emergency department; Acute; Address; Adenovirus Vector; Adherence; Adult; African American; Agreement; Area; Award; Baltimore; COVID-19; COVID-19 pandemic; COVID-19 prevention; Cardiac; Cardiopulmonary; Cessation of life; Child; Childhood; Cities; Clinical; Clinical Research; Clinical Trials; Clinical Trials Network; Collaborations; Communication; Communities; Country; County; Data Coordinating Center; Delaware; Discipline; Education; Emergency Care; Emergency Medicine; Emergency Situation; Emergency research; Emotional; Enrollment; Ethnic Origin; Evaluation; Faculty; Fellowship; Financial cost; Fostering; Funding; Future; Geographic Locations; Grant; Health Policy; Health Services; Health system; Hispanic Populations; Hospital Departments; Hospitals; Informatics; Injury; Institution; Language; Leadership; Lung; Maryland; Medicine; Minority Groups; Neurologic; Neurology; New Jersey; New York; Nursing Services; Outcome; Patient Care; Patients; Pennsylvania; Persons; Philadelphia; Population Heterogeneity; Pre-hospital setting; Process; Productivity; Protocols documentation; Provider; Race; Research; Research Design; Research Infrastructure; Research Personnel; Research Support; Rewards; Role; Route; Shock; Site; Societies; Socioeconomic Status; Structure; System; Time; Training; Translating; Trauma; Traumatic Brain Injury; United States National Institutes of Health; Universities; University Hospitals; Work; acute care; clinical practice; disability; improved; injured; innovation; meetings; member; minority patient; multidisciplinary; operation; participant enrollment; payment; pre-clinical; research and development; rural area; social; suburb; surveillance study; symposium; synergism; trauma centers; trial enrollment; vaccine trial; webinar; working group

The Temple-led Emergency care research network (Temple-SIREN) is comprised of multiple community and academic medical centers and EMS providers throughout Philadelphia, New Jersey, Delaware, and Maryland to execute SIREN emergency care trials. To meet the needs for specific study enrollment, Temple-SIREN engaged the highest volume emergency and trauma centers and the busiest EMS systems in the region. This large hub-spoke network serves very diverse populations in densely populated cities as well as highly affluent suburban areas to rural regions of Bucks and Berks counties in PA Dutch country. Temple-SIREN Hub and spoke leaders are committed to emergency care research and are active in trials of acute cardiopulmonary and neurological illness and traumatic brain injury trials. Through collaboration and hub oversight, the Temple-SIREN group expects to significantly contribute SIREN studies' enrollment. In addition, we plan to stay ahead of the curve by translating preclinical work to the bedside and using our highly diverse regional network for studies that needs of our diverse communities. The Temple-SIREN Hub staff will work closely with participating site investigators and coordinators from multiple disciplines to efficiently execute SIREN studies. Mechanisms to enhance efficiency and quality of clinical research across sites include use of a common informatics system to identify potential study patients; frequent communication with investigators and coordinators via webinars and conference calls; diligent site management focused on good clinical research practices and compliance, and regular Hub-spoke meetings to provide additional training by study role. Temple-SIREN investigators and coordinators will participate in SIREN clinical coordinating center and data management center and ad hoc working groups to develop SIREN studies. The Temple-SIREN Hub team would benefit from participating in this coordinated approach to emergency care research as would the people of Philadelphia and the surrounding communities served by our hospitals and EMS systems.

Temple-led Emergency Care Research Network（Temple-SIREN）由多个社区和学术医疗中心以及遍布费城、新泽西、特拉华州和马里兰州的EMS提供商组成，以执行SIREN紧急护理试验。为了满足特定研究招募的需求，Temple-SIREN聘请了该地区最大的急诊和创伤中心以及最繁忙的EMS系统。这个大型的中心辐射网络为人口密集的城市以及高度富裕的郊区到PA荷兰国家的巴克斯和伯克斯县的农村地区的各种人群提供服务。 Temple-SIREN中心和发言领导人致力于紧急护理研究，并积极参与急性心肺和神经疾病试验以及创伤性脑损伤试验。通过合作和中心监督，Temple-SIREN小组预计将大大有助于SIREN研究的招募。此外，我们计划通过将临床前工作转化为床边工作，并利用我们高度多样化的区域网络进行我们多样化社区所需的研究，从而保持领先地位。 Temple-SIREN Hub工作人员将与参与研究的研究中心研究者和多学科协调员密切合作，以有效执行SIREN研究。提高各研究中心临床研究效率和质量的机制包括使用通用信息系统识别潜在的研究患者;通过网络研讨会和电话会议与研究者和协调员频繁沟通;勤奋的研究中心管理，重点关注良好临床研究实践和合规性，以及定期召开中心发言会议，按研究角色提供额外培训。Temple-SIREN研究者和协调员将参与SIREN临床协调中心和数据管理中心以及特设工作组，以开展SIREN研究。Temple-SIREN Hub团队将受益于参与这种协调的紧急护理研究方法，费城人民和我们的医院和EMS系统所服务的周边社区也将受益。