Temple SIREN Emergency Care Clinical Research Hub

Temple SIRN 紧急护理临床研究中心

• 批准号: 9284164
• 负责人: NINA T GENTILE
• 金额: $ 25.36万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-15 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9284164
• 关键词: Academic Medical Centers; Accident and Emergency department; Acute; Address; Adherence; Adult; African American; Agreement; Ancillary Study; Area; Blood Coagulation Disorders; Blunt Trauma; Cardiology; Caring; Catchment Area; Cessation of life; Childhood; Chronic; Cities; Clinical; Clinical Research; Clinical Trials; Clinical Trials Network; Collaborations; Communication; Communities; Community Hospitals; Conduct Clinical Trials; Country; County; Data; Discipline; Emergency Care; Emergency Medicine; Emergency Situation; Emergency research; Emotional; Enrollment; Ethnic Origin; Evaluation; Financial cost; Funding; Future; Geographic Locations; Grant; Healthcare; Heart Arrest; Heart failure; Height; Hematology; Hispanics; Hospitals; Human Resources; Individual; Informatics; Injury; Institution; Language; Lead; Leadership; Lung; Medicine; Minority; Modeling; Monitor; Neurological emergencies; New Jersey; Observational Study; Patient Care; Patient Recruitments; Patients; Philadelphia; Population; Population Heterogeneity; Population Study; Prevention program; Process; Protocols documentation; Provider; Race; Reading; Records; Registries; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Research Subjects; Research Support; Respiratory distress; Role; Rural; Scientist; Site; Societies; Socioeconomic Status; Specialist; System; Time; Training; Translating; Trauma; Traumatic Brain Injury; United States National Institutes of Health; Universities; Work; acute stroke; base; bench to bedside; career; data management; design; disability; experience; improved; improved outcome; injured; interest; meetings; member; minority communities; outreach; population health; pre-clinical; rural area; social; suburb; symposium; translational study; trauma care; trauma centers; treatment trial; trend; violence prevention; webinar; working group

The Temple-led Emergency care research network comprised of multiple community and academic medical centers and EMS providers throughout Philadelphia, eastern PA and NJ have effectively conducted clinical trials together since 2007. To meet the needs for specific study enrollment, the group has grown from 2 to now 5 actively enrolling sites and is prepared to expand to 10 hospitals with the highest volume emergency and trauma centers and 6 of the busiest EMS systems all with an expressed interest in participating in pre- hospital research to cover the entire Philadelphia metro area and the suburban and rural areas that surround it. This large hub-spoke network spans very diverse populations including extremely poor, mostly African American and Hispanic communities in densely populated cities such as Philadelphia, Chester and Reading, to highly affluent areas in suburban Montgomery county, and to rural Bucks and Berks county in PA Dutch country. Temple-SIREN hub and spoke leaders have had career-long commitment to emergency care and are active in translational, pre-hospital and clinical research in heart failure and cardiac arrest, respiratory distress, disorders of coagulation and treatment of exsanguination, acute stroke and traumatic brain injury and severe penetrating and blunt trauma, all fertile ground for SIREN studies. These clinician-scientists in Emergency Medicine, Cardiology, Pulmonary, Hematology, Neurocritical, and Trauma care are leaders in their fields and set the standards for care for patients with acute illness and injury. Through collaboration and hub oversight, the Temple-SIREN group expects to significantly contribute SIREN studies' enrollment. In addition, we plan to stay ahead of the curve by translating preclinical work to the bedside and using our highly diverse regional network for population studies to address racial and social determinants of emergency care in our region. The Temple-SIREN HUB staff plans to work closely with participating site investigators and coordinators from multiple disciplines to efficiently execute SIREN studies. Mechanisms to enhance efficiency and quality of clinical research across sites include use of a common informatics system to identify potential study patients; frequent communication with investigators and coordinators via webinars and conference calls; diligent site management focused on good clinical research practices and compliance and yearly HUB-spoke meetings to provide additional training by study role. Temple-SIREN investigators and coordinators are expect to work with the SIREN clinical coordinating center and data management center and ad hoc working groups to design and operationalize SIREN studies. The Temple-SIREN HUB team would benefit from participating in this coordinated approach to emergency care research as would the people of Philadelphia and the surrounding communities served by our hospitals and EMS systems.

圣殿领导的紧急护理研究网络由多个社区和学术 费城、宾夕法尼亚州东部和新泽西州的医疗中心和EMS供应商已经有效地进行了 自2007年以来，临床试验。为了满足特定研究招生的需要，该集团已从2 到目前为止，有5家积极招募研究中心，并准备扩展到10家急诊量最高的医院 和创伤中心和6个最繁忙的EMS系统都表示有兴趣参加预- 医院研究覆盖整个费城都会区及其周围的郊区和农村地区。 这个大型的中心辐射网络覆盖了非常多样化的人口，包括极端贫困的人口，其中大部分是非洲人。 在费城、切斯特和阅读等人口稠密的城市， 蒙哥马利县郊区的高度富裕地区以及宾夕法尼亚州荷兰人的农村巴克斯和伯克斯县 国家 Temple-SIREN中心和发言领导人对紧急护理有着长期的职业承诺， 积极参与心力衰竭和心脏骤停、呼吸窘迫的转化、院前和临床研究， 凝血障碍和治疗失血，急性中风和创伤性脑损伤和严重 穿透性和钝性创伤都是SIREN研究的沃土这些临床科学家在紧急情况下 内科、心脏病学、肺科、血液学、神经重症和创伤护理是各自领域的领导者， 为急性疾病和受伤病人的护理制定标准。通过协作和枢纽监督， Temple-SIREN小组期望显著地贡献SIREN研究的登记。此外，我们计划 通过将临床前工作转化到床边，并利用我们高度多样化的区域， 人口研究网络，以解决本地区紧急护理的种族和社会决定因素。 Temple-SIREN HUB工作人员计划与参与的研究中心研究者和协调员密切合作 来自多个学科，以有效执行SIREN研究。提高效率和质量的机制 跨研究中心的临床研究包括使用通用信息系统识别潜在的研究患者; 通过网络研讨会和电话会议与研究者和协调员频繁沟通;勤奋的研究中心 管理层专注于良好的临床研究实践和合规性，每年召开中心发言会议， 按研究角色提供额外培训。Temple-SIREN调查人员和协调员预计将与 SIREN临床协调中心和数据管理中心以及特设工作组， 开展SIREN研究。Temple-SIREN HUB团队将从参与此活动中受益 协调的方法，以紧急护理研究，将费城和周围的人 我们的医院和EMS系统所服务的社区。