Understanding multisensory hypersensitivity in chronic pain states
Understanding multisensory hypersensitivity in chronic pain states
批准号:
10551884
负责人:
Mary Magdalen Heinricher
金额:
$37.0万
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-01-15 至 2024-11-30
关键词:
Anesthesia proceduresAnimal ModelAnimalsBehaviorBehavioralBrainBrain StemCellsChronicClinicalDependenceElectrophysiology (science)ElementsEndocrineEquilibriumEsthesiaFunctional disorderHyperalgesiaHypersensitivityHypothalamic structureInflammationInflammatoryLaboratoriesLightMechanicsMigraineModalityModelingNeuronsNociceptionOutputPainPainlessPathway interactionsPatientsPersistent painPhonophobiasPhotophobiaPhotosensitivityRattusReportingResponse to stimulus physiologyRodent ModelRoleSensorySmell PerceptionStimulusStressStructureSystemTestingThalamic structureTrigeminal SystemVisual PathwaysWorkactive controlantinociceptionbehavioral responsechronic painchronic pain patientchronic painful conditionclinical painextracellularinsightmigraine treatmentmultisensoryneuralneurobiological mechanismresponsesoundtransmission processvisual stimulus
中文摘要
项目摘要
许多慢性疼痛患者抱怨对多种感觉的异常敏感性
形态,包括光、声音和气味。潜在的神经基础仍然是一个谜
这些说法往往被怀疑,因为感官敏锐度本身并不
在初级感觉通路中也没有增强的处理。中央
这项提议的论点是,脑干疼痛调节系统的功能障碍,
被认为有助于在这些条件下的疼痛,也可能在多感觉中发挥作用。
超敏反应。这一假设是基于我们意外的观察,
延髓头端腹内侧区的疼痛调节神经元,是一个重要的
脑干疼痛调节系统对光有反应在三个特定的目标使用单细胞
记录方法在大鼠中,我们将充分表征RVM对光的反应,
刺激-反应函数并建立相关频谱。我们还将确定
在偏头痛动物模型中这些神经元的光反应性是否增强
头痛(其中光敏性是有据可查的)或处于持续性炎症状态。
最后,我们将从更高的角度研究光响应性的“自上而下”调制。
已知有助于应激诱发的痛觉过敏的大脑结构,
内分泌、自主神经和行为反应。现时的建议
将电生理学和行为学方法结合起来,
参与疼痛调节系统,有效地将视觉刺激转化为躯体刺激,
感觉,产生不适和厌恶。这些研究将提供基本的
深入了解多感觉超敏反应的神经生物学机制,信息
对于开发更合适的治疗偏头痛和其他慢性疼痛的方法至关重要
紊乱
英文摘要
PROJECT SUMMARY
Many chronic pain patients complain of abnormal sensitivity to multiple sensory
modalities, including light, sound, and smell. The underlying neural basis remains a puzzle
and these claims are often viewed with suspicion, since sensory acuity per se is not
enhanced, nor is there amplified processing in primary sensory pathways. The central
thesis of this proposal is that dysfunction of brainstem pain-modulating systems, already
thought to contribute to pain in these conditions, is also likely to play a role in multisensory
hypersensitivity. This hypothesis is based on our unexpected observation that a subset of
pain-modulating neurons in the rostral ventromedial medulla, the final output of an important
brainstem pain-modulating system, respond to light. In three Specific Aims using single-cell
recording approaches in rat, we will fully characterize the RVM response to light, generating
stimulus-response functions and establishing the relevant spectrum. We will also determine
whether photoresponsiveness of these neurons is enhanced in an animal model of migraine
headache (where photosensitivity is well documented) or in a persistent inflammatory state.
Finally, we will investigate “top-down” modulation of photoresponsiveness from a higher
brain structure known to contribute to stress-induced hyperalgesia and implicated in
endocrine, autonomic, and behavioral responses to mild stress. The present proposal
brings together electrophysiological and behavioral approaches to determine how light
engages pain-modulating systems, effectively converting a visual stimulus to a somatic
sensation, producing discomfort and aversion. These studies will provide fundamental
insights into the neurobiological mechanisms of multisensory hypersensitivity, information
critical to developing more appropriate treatments for migraine and other chronic pain
disorders.
期刊论文(2)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1016/j.ynpai.2021.100075
发表时间:
2021-08
期刊:
Neurobiology of pain (Cambridge, Mass.)
影响因子:
--
作者:
[Hryciw G, De Preter CC, Wong J, Heinricher MM]
通讯作者:
Heinricher MM
Unmasking the Pain in Latent Sensitization.
揭开潜在敏感化的痛苦。
DOI:
10.1016/j.neuroscience.2018.04.007
发表时间:
2018
期刊:
Neuroscience
影响因子:
3.3
作者:
[Chen,QiLiang, Heinricher,MaryM]
通讯作者:
Heinricher,MaryM
Defining the descending pain modulatory circuit
-
批准号:10656343
-
项目类别:
-
资助金额:$45.83万
-
财政年份:2022
-
负责人:Mary Magdalen Heinricher
-
依托单位:
Defining the descending pain modulatory circuit
-
批准号:10712085
-
项目类别:
-
资助金额:$53.17万
-
财政年份:2022
-
负责人:Mary Magdalen Heinricher
-
依托单位:
Defining the descending pain modulatory circuit
-
批准号:10461117
-
项目类别:
-
资助金额:$4.77万
-
财政年份:2021
-
负责人:Mary Magdalen Heinricher
-
依托单位:
Defining the descending pain modulatory circuit
-
批准号:10316551
-
项目类别:
-
资助金额:$60.73万
-
财政年份:2021
-
负责人:Mary Magdalen Heinricher
-
依托单位:
Rodent model of alcohol related hyperalgesia
-
批准号:10189448
-
项目类别:
-
资助金额:$34.65万
-
财政年份:2017
-
负责人:Mary Magdalen Heinricher
-
依托单位:
Understanding multisensory hypersensitivity in chronic pain states
-
批准号:9332614
-
项目类别:
-
资助金额:$37.48万
-
财政年份:2017
-
负责人:Mary Magdalen Heinricher
-
依托单位:
Understanding multisensory hypersensitivity in chronic pain states
-
批准号:10348325
-
项目类别:
-
资助金额:$37.0万
-
财政年份:2017
-
负责人:Mary Magdalen Heinricher
-
依托单位:
Cannabinoid and opioid modulation of descending pain circuits in chronic pain
-
批准号:9904615
-
项目类别:
-
资助金额:$40.17万
-
财政年份:2017
-
负责人:Mary Magdalen Heinricher
-
依托单位:
Rodent model of alcohol related hyperalgesia
-
批准号:9380282
-
项目类别:
-
资助金额:$34.65万
-
财政年份:2017
-
负责人:Mary Magdalen Heinricher
-
依托单位:
Understanding multisensory hypersensitivity in chronic pain states
-
批准号:10372237
-
项目类别:
-
资助金额:$37.0万
-
财政年份:2017
-
负责人:Mary Magdalen Heinricher
-
依托单位:
Rodent model of alcohol related hyperalgesia
-
批准号:9976399
-
项目类别:
-
资助金额:$34.65万
-
财政年份:2017
-
负责人:Mary Magdalen Heinricher
-
依托单位:
Brainstem pain-modulating systems in migraine-related photophobia
-
批准号:8459132
-
项目类别:
-
资助金额:$33.69万
-
财政年份:2012
-
负责人:Mary Magdalen Heinricher
-
依托单位:
Brainstem pain-modulating systems in migraine-related photophobia
-
批准号:8887169
-
项目类别:
-
资助金额:$33.69万
-
财政年份:2012
-
负责人:Mary Magdalen Heinricher
-
依托单位:
Brainstem pain-modulating systems in migraine-related photophobia
-
批准号:8537990
-
项目类别:
-
资助金额:$32.51万
-
财政年份:2012
-
负责人:Mary Magdalen Heinricher
-
依托单位:
Brainstem pain-modulating systems in migraine-related photophobia
-
批准号:8694118
-
项目类别:
-
资助金额:$33.35万
-
财政年份:2012
-
负责人:Mary Magdalen Heinricher
-
依托单位:
Medullary Circuitry of Pain Facilitation
-
批准号:8278649
-
项目类别:
-
资助金额:$32.64万
-
财政年份:2010
-
负责人:Mary Magdalen Heinricher
-
依托单位:
Medullary Circuitry of Pain Facilitation
-
批准号:8464813
-
项目类别:
-
资助金额:$31.45万
-
财政年份:2010
-
负责人:Mary Magdalen Heinricher
-
依托单位:
Medullary Circuitry of Pain Facilitation
-
批准号:8065848
-
项目类别:
-
资助金额:$32.69万
-
财政年份:2010
-
负责人:Mary Magdalen Heinricher
-
依托单位:
Medullary Circuitry of Pain Facilitation
-
批准号:7995114
-
项目类别:
-
资助金额:$32.75万
-
财政年份:2010
-
负责人:Mary Magdalen Heinricher
-
依托单位:
Migraine headache and central pain facilitating systems
-
批准号:7643748
-
项目类别:
-
资助金额:$38.13万
-
财政年份:2009
-
负责人:Mary Magdalen Heinricher
-
依托单位:
海外基金