Understanding multisensory hypersensitivity in chronic pain states

了解慢性疼痛状态下的多感觉超敏反应

基本信息

项目摘要

PROJECT SUMMARY Many chronic pain patients complain of abnormal sensitivity to multiple sensory modalities, including light, sound, and smell. The underlying neural basis remains a puzzle and these claims are often viewed with suspicion, since sensory acuity per se is not enhanced, nor is there amplified processing in primary sensory pathways. The central thesis of this proposal is that dysfunction of brainstem pain-modulating systems, already thought to contribute to pain in these conditions, is also likely to play a role in multisensory hypersensitivity. This hypothesis is based on our unexpected observation that a subset of pain-modulating neurons in the rostral ventromedial medulla, the final output of an important brainstem pain-modulating system, respond to light. In three Specific Aims using single-cell recording approaches in rat, we will fully characterize the RVM response to light, generating stimulus-response functions and establishing the relevant spectrum. We will also determine whether photoresponsiveness of these neurons is enhanced in an animal model of migraine headache (where photosensitivity is well documented) or in a persistent inflammatory state. Finally, we will investigate “top-down” modulation of photoresponsiveness from a higher brain structure known to contribute to stress-induced hyperalgesia and implicated in endocrine, autonomic, and behavioral responses to mild stress. The present proposal brings together electrophysiological and behavioral approaches to determine how light engages pain-modulating systems, effectively converting a visual stimulus to a somatic sensation, producing discomfort and aversion. These studies will provide fundamental insights into the neurobiological mechanisms of multisensory hypersensitivity, information critical to developing more appropriate treatments for migraine and other chronic pain disorders.
项目总结

项目成果

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Mary Magdalen Heinricher其他文献

Mary Magdalen Heinricher的其他文献

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{{ truncateString('Mary Magdalen Heinricher', 18)}}的其他基金

Defining the descending pain modulatory circuit
定义下行疼痛调节回路
  • 批准号:
    10656343
  • 财政年份:
    2022
  • 资助金额:
    $ 37.48万
  • 项目类别:
Defining the descending pain modulatory circuit
定义下行疼痛调节回路
  • 批准号:
    10712085
  • 财政年份:
    2022
  • 资助金额:
    $ 37.48万
  • 项目类别:
Defining the descending pain modulatory circuit
定义下行疼痛调节回路
  • 批准号:
    10461117
  • 财政年份:
    2021
  • 资助金额:
    $ 37.48万
  • 项目类别:
Defining the descending pain modulatory circuit
定义下行疼痛调节回路
  • 批准号:
    10316551
  • 财政年份:
    2021
  • 资助金额:
    $ 37.48万
  • 项目类别:
Rodent model of alcohol related hyperalgesia
酒精相关痛觉过敏啮齿动物模型
  • 批准号:
    10189448
  • 财政年份:
    2017
  • 资助金额:
    $ 37.48万
  • 项目类别:
Understanding multisensory hypersensitivity in chronic pain states
了解慢性疼痛状态下的多感觉超敏反应
  • 批准号:
    10551884
  • 财政年份:
    2017
  • 资助金额:
    $ 37.48万
  • 项目类别:
Understanding multisensory hypersensitivity in chronic pain states
了解慢性疼痛状态下的多感觉超敏反应
  • 批准号:
    10348325
  • 财政年份:
    2017
  • 资助金额:
    $ 37.48万
  • 项目类别:
Cannabinoid and opioid modulation of descending pain circuits in chronic pain
大麻素和阿片类药物对慢性疼痛中下行疼痛回路的调节
  • 批准号:
    9904615
  • 财政年份:
    2017
  • 资助金额:
    $ 37.48万
  • 项目类别:
Rodent model of alcohol related hyperalgesia
酒精相关痛觉过敏啮齿动物模型
  • 批准号:
    9380282
  • 财政年份:
    2017
  • 资助金额:
    $ 37.48万
  • 项目类别:
Understanding multisensory hypersensitivity in chronic pain states
了解慢性疼痛状态下的多感觉超敏反应
  • 批准号:
    10372237
  • 财政年份:
    2017
  • 资助金额:
    $ 37.48万
  • 项目类别:

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