Understanding multisensory hypersensitivity in chronic pain states
了解慢性疼痛状态下的多感觉超敏反应
基本信息
- 批准号:9332614
- 负责人:
- 金额:$ 37.48万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-01-15 至 2020-11-30
- 项目状态:已结题
- 来源:
- 关键词:Animal ModelAnimalsBehaviorBehavioralBrainBrain StemCellsChronicClinicalDependenceElectrophysiology (science)ElementsEndocrineEquilibriumEsthesiaFunctional disorderHyperalgesiaHypersensitivityHypothalamic structureInflammationInflammatoryLaboratoriesLightMechanicsMigraineModalityModelingNeuronsNociceptionOutputPainPain DisorderPainlessPathway interactionsPatientsPersistent painPhonophobiasPhotophobiaPhotosensitivityPlayRattusReportingResponse to stimulus physiologyRodent ModelRoleSensorySmell PerceptionStimulusStressStructureSystemTestingThalamic structureTrigeminal SystemVisual PathwaysWorkactive controlbasebehavioral responsechronic painextracellularinsightmultisensoryneurobiological mechanismrelating to nervous systemresponsesoundtransmission processvisual stimulus
项目摘要
PROJECT SUMMARY
Many chronic pain patients complain of abnormal sensitivity to multiple sensory
modalities, including light, sound, and smell. The underlying neural basis remains a puzzle
and these claims are often viewed with suspicion, since sensory acuity per se is not
enhanced, nor is there amplified processing in primary sensory pathways. The central
thesis of this proposal is that dysfunction of brainstem pain-modulating systems, already
thought to contribute to pain in these conditions, is also likely to play a role in multisensory
hypersensitivity. This hypothesis is based on our unexpected observation that a subset of
pain-modulating neurons in the rostral ventromedial medulla, the final output of an important
brainstem pain-modulating system, respond to light. In three Specific Aims using single-cell
recording approaches in rat, we will fully characterize the RVM response to light, generating
stimulus-response functions and establishing the relevant spectrum. We will also determine
whether photoresponsiveness of these neurons is enhanced in an animal model of migraine
headache (where photosensitivity is well documented) or in a persistent inflammatory state.
Finally, we will investigate “top-down” modulation of photoresponsiveness from a higher
brain structure known to contribute to stress-induced hyperalgesia and implicated in
endocrine, autonomic, and behavioral responses to mild stress. The present proposal
brings together electrophysiological and behavioral approaches to determine how light
engages pain-modulating systems, effectively converting a visual stimulus to a somatic
sensation, producing discomfort and aversion. These studies will provide fundamental
insights into the neurobiological mechanisms of multisensory hypersensitivity, information
critical to developing more appropriate treatments for migraine and other chronic pain
disorders.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Mary Magdalen Heinricher其他文献
Mary Magdalen Heinricher的其他文献
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{{ truncateString('Mary Magdalen Heinricher', 18)}}的其他基金
Understanding multisensory hypersensitivity in chronic pain states
了解慢性疼痛状态下的多感觉超敏反应
- 批准号:
10551884 - 财政年份:2017
- 资助金额:
$ 37.48万 - 项目类别:
Understanding multisensory hypersensitivity in chronic pain states
了解慢性疼痛状态下的多感觉超敏反应
- 批准号:
10348325 - 财政年份:2017
- 资助金额:
$ 37.48万 - 项目类别:
Cannabinoid and opioid modulation of descending pain circuits in chronic pain
大麻素和阿片类药物对慢性疼痛中下行疼痛回路的调节
- 批准号:
9904615 - 财政年份:2017
- 资助金额:
$ 37.48万 - 项目类别:
Understanding multisensory hypersensitivity in chronic pain states
了解慢性疼痛状态下的多感觉超敏反应
- 批准号:
10372237 - 财政年份:2017
- 资助金额:
$ 37.48万 - 项目类别:
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