Understanding multisensory hypersensitivity in chronic pain states
了解慢性疼痛状态下的多感觉超敏反应
基本信息
- 批准号:10348325
- 负责人:
- 金额:$ 37万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-01-15 至 2023-11-30
- 项目状态:已结题
- 来源:
- 关键词:Animal ModelAnimalsBehaviorBehavioralBrainBrain StemCellsChronicClinicalDependenceElectrophysiology (science)ElementsEndocrineEquilibriumEsthesiaFunctional disorderHyperalgesiaHypersensitivityHypothalamic structureInflammationInflammatoryLaboratoriesLightMechanicsMigraineModalityModelingNeuronsNociceptionOutputPainPainlessPathway interactionsPatientsPersistent painPhonophobiasPhotophobiaPhotosensitivityPlayRattusReportingResponse to stimulus physiologyRodent ModelRoleSensorySmell PerceptionStimulusStressStructureSystemTestingThalamic structureTrigeminal SystemVisual PathwaysWorkactive controlbasebehavioral responsechronic painchronic pain patientchronic painful conditionclinical painextracellularinsightmultisensoryneurobiological mechanismrelating to nervous systemresponsesoundtransmission processvisual stimulus
项目摘要
PROJECT SUMMARY
Many chronic pain patients complain of abnormal sensitivity to multiple sensory
modalities, including light, sound, and smell. The underlying neural basis remains a puzzle
and these claims are often viewed with suspicion, since sensory acuity per se is not
enhanced, nor is there amplified processing in primary sensory pathways. The central
thesis of this proposal is that dysfunction of brainstem pain-modulating systems, already
thought to contribute to pain in these conditions, is also likely to play a role in multisensory
hypersensitivity. This hypothesis is based on our unexpected observation that a subset of
pain-modulating neurons in the rostral ventromedial medulla, the final output of an important
brainstem pain-modulating system, respond to light. In three Specific Aims using single-cell
recording approaches in rat, we will fully characterize the RVM response to light, generating
stimulus-response functions and establishing the relevant spectrum. We will also determine
whether photoresponsiveness of these neurons is enhanced in an animal model of migraine
headache (where photosensitivity is well documented) or in a persistent inflammatory state.
Finally, we will investigate “top-down” modulation of photoresponsiveness from a higher
brain structure known to contribute to stress-induced hyperalgesia and implicated in
endocrine, autonomic, and behavioral responses to mild stress. The present proposal
brings together electrophysiological and behavioral approaches to determine how light
engages pain-modulating systems, effectively converting a visual stimulus to a somatic
sensation, producing discomfort and aversion. These studies will provide fundamental
insights into the neurobiological mechanisms of multisensory hypersensitivity, information
critical to developing more appropriate treatments for migraine and other chronic pain
disorders.
项目摘要
许多慢性疼痛患者抱怨对多种感觉的异常敏感性
形态,包括光、声音和气味。潜在的神经基础仍然是一个谜
这些说法往往被怀疑,因为感官敏锐度本身并不
在初级感觉通路中也没有增强的处理。中央
这项提议的论点是,脑干疼痛调节系统的功能障碍,
被认为有助于在这些条件下的疼痛,也可能在多感觉中发挥作用。
超敏反应这一假设是基于我们意外的观察,
延髓头端腹内侧区的疼痛调节神经元,是一个重要的
脑干疼痛调节系统对光有反应在三个特定的目标使用单细胞
记录方法在大鼠中,我们将充分表征RVM对光的反应,
刺激-反应函数并建立相关频谱。我们还将确定
在偏头痛动物模型中这些神经元的光反应性是否增强
头痛(其中光敏性是有据可查的)或处于持续性炎症状态。
最后,我们将从更高的角度研究光响应性的"自上而下"调制。
已知有助于应激诱发的痛觉过敏的大脑结构,
内分泌、自主神经和行为反应。现时的建议
将电生理学和行为学方法结合起来,
参与疼痛调节系统,有效地将视觉刺激转化为躯体刺激,
感觉,产生不适和厌恶。这些研究将提供基本的
深入了解多感觉超敏反应的神经生物学机制,信息
对于开发更合适的治疗偏头痛和其他慢性疼痛的方法至关重要
紊乱
项目成果
期刊论文数量(0)
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会议论文数量(0)
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Mary Magdalen Heinricher其他文献
Mary Magdalen Heinricher的其他文献
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{{ truncateString('Mary Magdalen Heinricher', 18)}}的其他基金
Understanding multisensory hypersensitivity in chronic pain states
了解慢性疼痛状态下的多感觉超敏反应
- 批准号:
9332614 - 财政年份:2017
- 资助金额:
$ 37万 - 项目类别:
Understanding multisensory hypersensitivity in chronic pain states
了解慢性疼痛状态下的多感觉超敏反应
- 批准号:
10551884 - 财政年份:2017
- 资助金额:
$ 37万 - 项目类别:
Cannabinoid and opioid modulation of descending pain circuits in chronic pain
大麻素和阿片类药物对慢性疼痛中下行疼痛回路的调节
- 批准号:
9904615 - 财政年份:2017
- 资助金额:
$ 37万 - 项目类别:
Understanding multisensory hypersensitivity in chronic pain states
了解慢性疼痛状态下的多感觉超敏反应
- 批准号:
10372237 - 财政年份:2017
- 资助金额:
$ 37万 - 项目类别:
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