Administrative Core

项目总结 拟议的行政核心(核心A)将与拟议的4个项目和 另外两个拟议核心：科学核心和数据管理和分析核心。我们有 制定了详细的计划，努力优化项目、核心和 参与本U19续期申请中所建议的研究的人员。这样的互动将得到促进 由于斯坦福大学存在人类免疫监测核心(HIMC)等资源，其中 科学核心的工作将被进行，其主任Holden Maecker也是我们的 建议的科学核心。该U19可用的其他资源包括肖恩·N·帕克过敏中心 和哮喘研究，由项目3的负责人Kari Nadeau博士指导，以及临床和 翻译研究单位(CTRU)，由项目1负责人Sharon Chinthrajah博士指导。值得注意的是， 斯坦福大学团队的成员已经在目前的AADCRC U19下进行科学互动 程序。因此，如果这一续期申请获得资金，拟议的工作将推进我们的 了解食物过敏的病理机制，以及导致脱敏和 在这种混乱中，容忍将代表着这些正在进行的持续和实质性的扩展 合作努力。 行政核心有两个具体目标： 目标1：提供科学的管理和协调，以支持斯坦福非洲发展研究中心的目标； 目标2：提供财政监督和管理。 AIM 1的一个特点是，斯坦福大学免疫研究所所长马克·戴维斯博士， 移植和感染(ITI)将与申请的PI共同主持科学咨询 这款U19的董事会，为该团队提供了他在许多其他人类免疫方面获得的专业知识 监测在HIMC(设在国际信息技术研究所)的协助下开展的项目。《科学》 顾问委员会还将包括著名的系统免疫学家巴厘·普伦德兰博士和安迪·火博士，他是一名 著名的分子生物学家，他也将成为项目2的联合调查员。

PROJECT SUMMARY The proposed Administrative Core (Core A) will interact closely will each of the proposed 4 projects and the two other proposed cores: the Scientific Core and the Data Management and Analysis Core. We have developed a detailed plan to strive to optimize the synergy and interactions among the projects, cores and personnel involved in the studies proposed in this U19 renewal application. Such interactions will be facilitated by the existence, at Stanford, of resources such as the Human Immune Monitoring Core (HIMC), in which the work in Scientific Core will be conducted and whose director, Holden Maecker, is also the director of our proposed Scientific Core. Other resources available to this U19 include the Sean N. Parker Center for Allergy and Asthma Research, which is directed by Dr. Kari Nadeau, who is the Project 3 Lead, and the Clinical and Translational Research Unit (CTRU), which is directed by the Project 1 Lead, Dr. Sharon Chinthrajah. Notably, the members of the Stanford team are already interacting scientifically under the current AADCRC U19 program. Accordingly, should this renewal application be funded, the proposed work to advance our understanding of the pathology of food allergy, and the mechanisms that contribute to desensitization and tolerance in this disorder, will represent a continuation and substantial expansion of these ongoing collaborative efforts. The Administrative Core has two Specific Aims: Aim 1: Provide scientific administration and coordination in support of the objectives of the Stanford AADCRC; Aim 2: Provide fiscal oversight and administration. A special feature of Aim 1 is that Dr. Mark Davis, director of the Stanford Institute for Immunology, Transplantation, & Infection (ITI), will co-chair, along with the PI of the application, the Scientific Advisory Board for this U19, providing the group with the expertise he has acquired in many other human immune monitoring projects being pursued with the assistance of the HIMC (that is housed in ITI). The Scientific Advisory Board also will include Dr. Bali Pulendran, a renowned systems immunologist, and Dr. Andy Fire, a noted molecular biologist who also will be a Co-Investigator in Project 2.