Biostatistics and Bioinformatics (BBSR)

生物统计学和生物信息学（BBSR）

• 批准号: 10554243
• 负责人: TOR D TOSTESON
• 金额: $ 39.7万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-04 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10554243
• 关键词: Administrative Efficiency; Applications Grants; Award; Behavioral Research; Bioinformatics; Bioinformatics Shared Resource; Biometry; Biotechnology; Budgets; Cancer Biology; Cancer Center Support Grant; Cancer Detection; Client; Clinic; Clinical Cancer Center; Clinical Protocols; Clinical Research; Clinical Trials Design; Collaborations; Comparative Effectiveness Research; Computer Systems; Computer software; Consult; Consultations; Data; Data Analyses; Databases; Development; Education; Engineering; Faculty; Funding; Gene set enrichment analysis; Genetic; Genomics; Goals; High Performance Computing; Home; Individual; Information Systems; Institution; Machine Learning; Malignant Neoplasms; Manuscripts; Mentors; Methodology; Monitor; Norris Cotton Cancer Center; Pathway Analysis; Pathway interactions; Pediatrics; Peer Review; Population Sciences; Protocols documentation; Publications; Quality of life; Randomized; Reporting; Research Design; Research Personnel; Research Proposals; Research Support; Resource Informatics; Resource Sharing; Resources; Safety; Sample Size; Science; Services; Site; Statistical Methods; Statistical Study; Terminal Disease; Therapeutic; Time; Translational Research; United States National Institutes of Health; Walking; anticancer research; bioinformatics resource; biomedical data science; computer cluster; data management; data mining; design; experience; genomic data; image processing; medical specialties; member; novel; parallel computer; programs; protocol development; response; sound; tool

Project Summary/Abstract: Biostatistics and Bioinformatics The Biostatistics and Bioinformatics Shared Resource (BBSR) offers comprehensive statistical and bioinformatics consultation, collaboration, and technical services to all Norris Cotton Cancer Center (NCCC) Programs. All BBSR statisticians and bioinformaticians are equipped with state-of-the-art workstations with general and specialty statistical packages, such as SAS, R, RStudio, PASS, NQuery, SPSS, MPlus, and Winbugs. High-performance computing relies on access to a 2000+ processor parallel computer cluster (Discovery). Ten (10) faculty from the Departments of Biomedical Data Sciences, The Dartmouth Institute, and Pediatrics serve as scientific collaborators in clinical trial and research design, advise on and participate in statistical study management, perform statistical oversight, and conduct data analyses. State-of-the-art capabilities are evident in BBSR faculty having obtained two PCORI Methodology Awards, two NIH R01s, and two individual K01s during the current funding period. Since the last review, four new faculty have joined the Shared Resource (i.e., Drs. Frost [CBT], Emond [CPS], Gorlov [CPS] and Moen [CPS]), strengthening support for behavioral research and network analysis, and formerly separate Biostatistics and Bioinformatics resources have been merged to better coordinate faculty expertise and take advantage of administrative efficiencies. More than 300 peer-reviewed cancer-related publications involving BBSR faculty as co-authors appeared in the current reporting period. The breadth of BBSR impact is evident in examples of the development of collaboration with Cancer Population Sciences investigators on specialized statistical methods for analyzing terminal declines in quality of life, gene set enrichment analyses performed with the Cancer Biology and Therapeutics Program to identify pathways presenting potential therapeutic opportunity, and advanced image processing and machine learning to assist Translational Engineering in Cancer investigators in cancer detection. The Division of Biostatistics in the new Department of Biomedical Science serves as the BBSR organizational home, but nine of the 10 faculty are housed on site in the NCCC Rubin Building. Dr. Tor Tosteson (CPS) has served as Shared Resource Director for more than 20 years. Faculty meet monthly to coordinate activities, and a second faculty member provides an independent review of protocols and internally- funded projects with a BBSR co-investigator. During the current reporting period, 126 BBSR clients were NCCC Members at the time of service (CPS [62], CBT [33], ICI [16], TEC [15]). 56 NCCC Members, in addition to 300 publications, collaborated on 62 grant applications. Funded NCCC Members represented 29% (73) of Total Users, and we are requesting only 13% of the Total BBSR budget from CCSG support. New initiatives to augment services to NCCC Members include formal designation of BBSR faculty for participation on mentoring committees. Additionally, walk-in clinics are being established for short consult requiring primarily quick advice for researchers at many levels of statistical sophistication.

项目摘要/摘要：生物统计学和生物信息学 生物统计和生物信息学共享资源(BBSR)提供全面的统计和 为全诺里斯棉花癌症中心(NCCC)提供生物信息学咨询、协作和技术服务 程序。所有BBSR统计员和生物信息学家都配备了最先进的工作站， 通用和专业统计包，如SAS、R、RStudio、PASS、NQuery、SPSS、MPlus和 温巴格。高性能计算依赖于对2000多个处理器的并行计算机集群的访问 (发现)。来自生物医学数据科学系、达特茅斯研究所和 儿科作为临床试验和研究设计的科学合作者，为临床试验和研究设计提供建议并参与 统计研究管理，执行统计监督，并进行数据分析。最先进的 BBSR教师在获得两项PCORI方法论奖、两项NIH R01奖和 在本供资期间有两个单独的K01。自上次审查以来，已有四名新教员加入 共享资源(即Frost博士[CBT]、Emond[CPS]、Gorlov[CPS]和Moen[CPS])，加强 支持行为研究和网络分析，以前将生物统计学和生物信息学分开 资源已被合并，以更好地协调教师专业知识并利用行政管理 效率。300多篇同行评议的癌症相关出版物，BBSR的教职员工是合著者 出现在本报告所述期间。BBSR影响的广度从以下例子中可见一斑 与癌症人口科学研究人员在专门统计方法方面的合作进展 为了分析晚期生活质量的下降，对癌症患者进行了基因集丰富分析 生物学和治疗学计划，以确定提供潜在治疗机会的途径，以及 先进的图像处理和机器学习为癌症研究人员的翻译工程提供帮助 在癌症检测方面。新成立的生物医学科学系的生物统计学部门是 BBSR的组织之家，但10名教职员工中有9名住在NCCC鲁宾大楼的现场。托尔博士 Tosteson(CPS)担任共享资源总监已有20多年。教职员工每月开会至 协调活动，第二名教员提供对协议的独立审查，并在内部- 与BBSR合作调查员共同资助的项目。在本报告所述期间，有126个BBSR客户 服务时的NCCC成员(CPS[62]、CBT[33]、ICI[16]、TEC[15])。56名NCCC成员，此外 到300家出版物，就62项赠款申请进行了合作。资助的NCCC成员占29%(73) 总用户数，我们仅要求CCSG支持部门提供总BBSR预算的13%。新的计划以 为NCCC成员提供的补充服务包括正式指定BBSR教职员工参与指导 委员会。此外，还建立了无预约诊所，主要是为需要快速咨询的短期咨询服务。 对于具有多种统计复杂性水平的研究人员来说。