Core--Biostatistis and data management

达特茅斯SBRP的所有组成项目都从事统计分析和科学数据管理。拟议的生物统计学和数据管理核心的总体目标是通过为SBRP提供达特茅斯生物统计学专业知识和数据管理资源的全面访问，增强项目互动性和科学质量。拟议的项目涉及利用一些复杂和新颖的生物测定法的体外和整体动物实验方案（项目1-3，核心A）;基于人口的流行病学数据，包括个人接触和遗传标记的复杂生物标志物测量（项目4）;以及生态和地球化学调查中的多级聚类采样（项目6和7）。健全的统计方法和数据管理是成功实施这些项目的关键。通过在核心内共享统计人员、专业软件和计算资源的支持，实现了规模经济。这样，那些通常无法证明统计人员的全时当量界限合理的项目，在其实验和研究的设计和分析的关键阶段，仍然可以依靠专家统计资源。核心小组还将开发必要的强化统计方法，以便在使用多种接触生物标志物的基础上研究低至中度砷接触与癌症之间的关系，并将利用核心小组服务器（http：//biostat.hitchcock.org/sbrp.htm）上维护的独特网络统计软件。

All the component projects of the Dartmouth SBRP engage in statistical analysis and scientific data management. The overall objective of the proposed Biostatistics and Data Management Core is to enhance program interactivity and scientific quality by providing the SBRP full access to the biostatistical expertise and data management resources at Dartmouth. The proposed projects involve in vitro and whole animal experimental protocols utilizing a number of complex and novel complex and novel bioassays (Project 1-3, Core A); population-based epidemiologic data with sophisticated biomarker measures of individual exposure and genetic markers (Project 4); and multi-level clustered sampling in ecological and geochemical surveys (Projects 6 and 7). Sound statistical methodology and data management are essential for the successful conduct of these projects. Economics of scale are achieved by sharing the support of statistical personnel, specialized software, and computing resources within the Core. In this way, projects that would not be able ordinarily to justify FTE lines for statistical personnel can still count on expert statistical resources during critical phases of the design and analysis of their experiments and studies. The Core will also develop enhanced statistical methods necessary to study the relationship between low to moderate arsenic exposures and cancer based on the use of multiple biomarkers of exposure, and will make use of unique Web-based statistical software maintained on the Core server (http://biostat.hitchcock.org/sbrp.htm).