Methodology Core

项目总结(见说明)： 方法学核心的总体目标是提供生物统计学、结果和临床研究方面的创新方法学专业知识，以及成功完成MCRC拟议项目和研究基地内其他重要项目所需的计算资源。该中心还提供教育资源，目的是提高达特茅斯的肌肉骨骼疾病研究倡议的方法质量。具体目标是：1)促进所有MCRC项目的实施和完成，并通过提供生物统计、研究设计、成果等方面的专门知识，协助研究基地内的调查人员 研究、数据管理和先进计算；2)提供对专门数据库和计算资源的访问；3)建立一个有针对性的教育论坛，通过举办多学科临床研究中的研究进展研讨会，重点是肌肉骨骼疾病，为研究基地内的学术方案的博士后和博士后学员举办专门研讨会和指导研究课程，以及为研究生和研究生方案的高级学员提供方法学指导，从而在现有的研究基地内培养方法学专长。 与多学科研究中心有联系，4)为多学科研究中心项目的研究审查、数据和安全监测提供方法学支持，5)促进方法学研究，这些问题对推进研究基地内的具体领域至关重要。核心与达特茅斯地区的量化和教育资源高度整合并紧密结合，使整个机构能够更广泛地代表和相互分享专业知识。

PROJECT SUMMARY (See instructions): The overall objective of the Methodology Core is to provide access to innovative methodological expertise in biostatistics, outcomes and clinical research and along with computational resources necessary for the successful completion of the proposed MCRC projects and other important projects within the research base. The Core also provides an educational resource with the intent of enhancing the methodological quality of research initiatives in musculoskeletal diseases at Dartmouth. The specific aims are 1) to facilitate the implementation and completion of all MCRC projects and to assist investigators within the research base by providing expertise in biostatistics, research design, outcomes research, data management, and advanced computing, 2) to provide access to specialized data bases and computing resources, 3) to establish a targeted educational forum to foster methodological expertise within the existing research base by conducting research-in progress seminars in multidisciplinary clinical research with a focus on musculoskeletal disease, specialized seminars and directed research courses for pre- and post-doctoral trainees in the academic programs represented within the research base, and methodological mentorship for advanced trainees in graduate and post-graduate programs affiliated with the MCRC, 4) to provide methodological support for research review and data and safety monitoring for MCRC projects, and 5) to promote methodologic research in issues critical to the advancement of specific areas within the research base. The Core is highly integrated and closely aligned with quantitative and educational resources throughout Dartmouth, allowing for a broader representation and mutual sharing of expertise across the institution.