MEASUREMENT ERRORS IN EPIDEMIOLOGY--BREAST/COLON CANCER
MEASUREMENT ERRORS IN EPIDEMIOLOGY--BREAST/COLON CANCER
批准号:
2101861
负责人:
TOR D TOSTESON
金额:
$12.36万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1994
资助国家:
美国
项目状态:
已结题
起止时间:
1994-05-15 至 1997-04-30
中文摘要
正在研究的风险因素中的测量误差是
癌症流行病学中不精确和偏差的重要来源。一个
我们小组关注的例子是人与人之间的差异
在病例对照中收集的关于酒精使用的问卷数据
乳腺癌发病率的研究。最近又出现了一场新的
对研究处理这个问题的统计方法感兴趣。
在某种程度上,这种兴趣可以追溯到越来越多的人使用More
用于确定暴露和结果的复杂技术。
在测量误差方法方面的新研究主要集中在
关于流行病学家常用的技术,如二进制
回归和病例对照研究。然而,这样的情况相对较少
方法已经被引入到癌症的实践中
流行病学。
此应用程序的长期目标是鼓励
适当使用最近开发的测量误差方法。
这将通过开发和记录统计数据来实现
函数形式的方法,用于分析
流行病学数据。测量的成功应用--
误差方法的实际研究取决于误差方法的可用性
建议算法在计算机中的可靠实现
流行病学研究人员熟悉的软件格式。
统计文献中反复出现的主题之一是关于
二元回归中的测量误差是难以做到的
最大似然估计当似然包含一个
不能解析计算的积分。一批
作者,包括参与调查的调查人员
建议,提出了近似的推论方法
消除这种计算困难,包括有效的分数
广义线性模型的检验,最大值的逼近
Logistic回归的可能性,以及可积模型,如
具有正常测量误差的概率回归。这些方法
将被提炼和调整以用于病因学和
预防乳腺癌、结肠癌和皮肤癌。主要的重点将是
被放置在有助于确定适当的
流行病学调查的样本量
风险因素中的测量误差。
英文摘要
Errors of measurement in the risk factors under study are an
important source of imprecision and bias in cancer epidemiology. An
example of concern to our group is the within-person variability of
questionnaire data on alcohol use being collected in a case-control
study of breast cancer incidence. Recently there has been a renewed
interest in studying statistical methods for treating this problem.
In part, this interest can be traced to the growing use of more
sophisticated techniques for determining exposures and outcomes.
The new research in measurement error methods has primarily focused
on techniques commonly used by epidemiologists such as binary
regression and case-control studies. Yet relatively few of these
methods have been introduced into the practice of cancer
epidemiology.
The long term objective of this application is to encourage the
appropriate use of recently developed measurement-error methods.
This will be accomplished by developing and documenting statistical
methods in the form of functions for use in the analysis of
epidemiologic data. The successful application of measurement-
error methods to practical research depends on the availability of
reliable implementations of the suggested algorithms in a computer
software format familiar to researchers working in epidemiology.
One of the recurrent themes in statistical literature regarding
measurement errors in binary regression is the difficulty of doing
maximum likelihood estimation when the likelihood contains an
integral that cannot be evaluated analytically. A number of
authors, including the investigators participating in this
proposal, have suggested approximate methods of inference that
eliminate this computational difficulty, including efficient score
tests for generalized linear models, approximations to maximum
likelihood for logistic regression, and integrable models, such as
probit regression with normal measurement errors. These methods
will be refined and adapted for use in studies of the etiology and
prevention of breast, colon and skin cancer. A major emphasis will
be placed on procedures useful for determining the appropriate
sample size for epidemiologic investigations with substantial
errors of measurement in risk factors.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Quantitative Biomedical Sciences at Dartmouth
-
批准号:9462854
-
项目类别:
-
资助金额:$19.53万
-
财政年份:2016
-
负责人:TOR D TOSTESON
-
依托单位:
Outcomes Calculators for Informed Decision Making in Back Surgery
-
批准号:8712128
-
项目类别:
-
资助金额:$25.43万
-
财政年份:2014
-
负责人:TOR D TOSTESON
-
依托单位:
BIOSTATISTICS SHARED RESOURCE
-
批准号:7944672
-
项目类别:
-
资助金额:$19.66万
-
财政年份:2009
-
负责人:TOR D TOSTESON
-
依托单位:
Methodology Core
-
批准号:7426915
-
项目类别:
-
资助金额:$49.43万
-
财政年份:2007
-
负责人:TOR D TOSTESON
-
依托单位:
Core--Biostatistis and data management
-
批准号:6577239
-
项目类别:
-
资助金额:$16.33万
-
财政年份:2002
-
负责人:TOR D TOSTESON
-
依托单位:
Core--Biostatistis and data management
-
批准号:6666430
-
项目类别:
-
资助金额:$16.33万
-
财政年份:2002
-
负责人:TOR D TOSTESON
-
依托单位:
Core--Biostatistis and data management
-
批准号:6443947
-
项目类别:
-
资助金额:$16.33万
-
财政年份:2001
-
负责人:TOR D TOSTESON
-
依托单位:
Biostatistics and Bioinformatics (BBSR)
-
批准号:10311225
-
项目类别:
-
资助金额:$39.7万
-
财政年份:1997
-
负责人:TOR D TOSTESON
-
依托单位:
Biostatistics and Bioinformatics (BBSR)
-
批准号:10554243
-
项目类别:
-
资助金额:$39.7万
-
财政年份:1997
-
负责人:TOR D TOSTESON
-
依托单位:
Core--Biostatistis and data management
-
批准号:6331448
-
项目类别:
-
资助金额:$16.33万
-
财政年份:1995
-
负责人:TOR D TOSTESON
-
依托单位:
MEASUREMENT ERRORS IN EPIDEMIOLOGY--BREAST/COLON CANCER
-
批准号:2101863
-
项目类别:
-
资助金额:$12.56万
-
财政年份:1994
-
负责人:TOR D TOSTESON
-
依托单位:
MEASUREMENT ERRORS IN EPIDEMIOLOGY--BREAST/COLON CANCER
-
批准号:2101862
-
项目类别:
-
资助金额:$12.09万
-
财政年份:1994
-
负责人:TOR D TOSTESON
-
依托单位:
BIOSTATISTICS SHARED RESOURCE
-
批准号:8015010
-
项目类别:
-
资助金额:$20.88万
-
财政年份:--
-
负责人:TOR D TOSTESON
-
依托单位:
Outcomes Calculatiors for Informed Decision Making in Back Surgery
-
批准号:8293841
-
项目类别:
-
资助金额:$23.09万
-
财政年份:--
-
负责人:TOR D TOSTESON
-
依托单位:
Methodology Core
-
批准号:8917856
-
项目类别:
-
资助金额:$55.63万
-
财政年份:--
-
负责人:TOR D TOSTESON
-
依托单位:
BIOSTATISTICS SHARED RESOURCE
-
批准号:8255528
-
项目类别:
-
资助金额:$18.28万
-
财政年份:--
-
负责人:TOR D TOSTESON
-
依托单位:
Methodology Core
-
批准号:8712126
-
项目类别:
-
资助金额:$64.54万
-
财政年份:--
-
负责人:TOR D TOSTESON
-
依托单位:
BIOSTATISTICS SHARED RESOURCE
-
批准号:8376263
-
项目类别:
-
资助金额:$18.32万
-
财政年份:--
-
负责人:TOR D TOSTESON
-
依托单位:
BIOSTATISTICS SHARED RESOURCE
-
批准号:8787225
-
项目类别:
-
资助金额:$12.43万
-
财政年份:--
-
负责人:TOR D TOSTESON
-
依托单位:
Biostatistics (BSR)
-
批准号:9151852
-
项目类别:
-
资助金额:$27.13万
-
财政年份:--
-
负责人:TOR D TOSTESON
-
依托单位:
海外基金