MEASUREMENT ERRORS IN EPIDEMIOLOGY--BREAST/COLON CANCER
MEASUREMENT ERRORS IN EPIDEMIOLOGY--BREAST/COLON CANCER
批准号:
2101861
负责人:
TOR D TOSTESON
金额:
$12.36万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1994
资助国家:
美国
项目状态:
已结题
起止时间:
1994-05-15 至 1997-04-30
中文摘要
研究中的风险因素的测量误差是一个
癌症流行病学中不精确和偏差的重要来源。一个
我们小组关注的一个例子是人内的变异性,
在病例对照组中收集关于酒精使用的问卷数据
乳腺癌发病率的研究。最近,有一个新的
对研究处理这个问题的统计方法感兴趣。
在某种程度上,这种兴趣可以追溯到越来越多地使用更多的
确定风险和结果的复杂技术。
测量误差方法的新研究主要集中在
流行病学家常用的技术,如二进制
回归分析和病例对照研究。然而,其中相对较少的
方法已经被引入到癌症的实践中,
流行病学
这项申请的长远目标是鼓励
适当使用最近开发的测量误差方法。
这将通过制定和记录统计数据来实现。
函数形式的方法,用于分析
流行病学数据。 测量的成功应用-
错误的方法,以实际研究取决于可用性,
在计算机中可靠地实现所建议的算法
流行病学研究人员熟悉的软件格式。
统计文献中反复出现的一个主题是,
二元回归中的测量误差是一个难点,
最大似然估计,当可能性包含
不能用解析法计算的积分。一些
作者,包括参与这项研究的研究人员,
建议,提出了近似的推理方法,
消除这种计算困难,包括有效的分数
广义线性模型的检验,最大值的近似
逻辑回归的可能性,以及可积模型,例如
具有正常测量误差的概率单位回归。 这些方法
将被完善和调整,用于病因学研究,
预防乳腺癌、结肠癌和皮肤癌。一个主要的重点将是
应置于有助于确定适当的
流行病学调查的样本量
风险因素的测量误差。
英文摘要
Errors of measurement in the risk factors under study are an
important source of imprecision and bias in cancer epidemiology. An
example of concern to our group is the within-person variability of
questionnaire data on alcohol use being collected in a case-control
study of breast cancer incidence. Recently there has been a renewed
interest in studying statistical methods for treating this problem.
In part, this interest can be traced to the growing use of more
sophisticated techniques for determining exposures and outcomes.
The new research in measurement error methods has primarily focused
on techniques commonly used by epidemiologists such as binary
regression and case-control studies. Yet relatively few of these
methods have been introduced into the practice of cancer
epidemiology.
The long term objective of this application is to encourage the
appropriate use of recently developed measurement-error methods.
This will be accomplished by developing and documenting statistical
methods in the form of functions for use in the analysis of
epidemiologic data. The successful application of measurement-
error methods to practical research depends on the availability of
reliable implementations of the suggested algorithms in a computer
software format familiar to researchers working in epidemiology.
One of the recurrent themes in statistical literature regarding
measurement errors in binary regression is the difficulty of doing
maximum likelihood estimation when the likelihood contains an
integral that cannot be evaluated analytically. A number of
authors, including the investigators participating in this
proposal, have suggested approximate methods of inference that
eliminate this computational difficulty, including efficient score
tests for generalized linear models, approximations to maximum
likelihood for logistic regression, and integrable models, such as
probit regression with normal measurement errors. These methods
will be refined and adapted for use in studies of the etiology and
prevention of breast, colon and skin cancer. A major emphasis will
be placed on procedures useful for determining the appropriate
sample size for epidemiologic investigations with substantial
errors of measurement in risk factors.
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会议论文
Quantitative Biomedical Sciences at Dartmouth
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批准号:9462854
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资助金额:$19.53万
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财政年份:2016
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资助金额:$19.66万
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财政年份:2009
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负责人:TOR D TOSTESON
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依托单位:
Methodology Core
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批准号:7426915
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项目类别:
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资助金额:$49.43万
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财政年份:2007
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Core--Biostatistis and data management
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批准号:6577239
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项目类别:
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资助金额:$16.33万
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财政年份:2002
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负责人:TOR D TOSTESON
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依托单位:
Core--Biostatistis and data management
-
批准号:6666430
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项目类别:
-
资助金额:$16.33万
-
财政年份:2002
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负责人:TOR D TOSTESON
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依托单位:
Core--Biostatistis and data management
-
批准号:6443947
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项目类别:
-
资助金额:$16.33万
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财政年份:2001
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负责人:TOR D TOSTESON
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依托单位:
Biostatistics and Bioinformatics (BBSR)
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批准号:10311225
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项目类别:
-
资助金额:$39.7万
-
财政年份:1997
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负责人:TOR D TOSTESON
-
依托单位:
Biostatistics and Bioinformatics (BBSR)
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批准号:10554243
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项目类别:
-
资助金额:$39.7万
-
财政年份:1997
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负责人:TOR D TOSTESON
-
依托单位:
Core--Biostatistis and data management
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批准号:6331448
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项目类别:
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资助金额:$16.33万
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财政年份:1995
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负责人:TOR D TOSTESON
-
依托单位:
MEASUREMENT ERRORS IN EPIDEMIOLOGY--BREAST/COLON CANCER
-
批准号:2101863
-
项目类别:
-
资助金额:$12.56万
-
财政年份:1994
-
负责人:TOR D TOSTESON
-
依托单位:
MEASUREMENT ERRORS IN EPIDEMIOLOGY--BREAST/COLON CANCER
-
批准号:2101862
-
项目类别:
-
资助金额:$12.09万
-
财政年份:1994
-
负责人:TOR D TOSTESON
-
依托单位:
BIOSTATISTICS SHARED RESOURCE
-
批准号:8015010
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项目类别:
-
资助金额:$20.88万
-
财政年份:--
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负责人:TOR D TOSTESON
-
依托单位:
Outcomes Calculatiors for Informed Decision Making in Back Surgery
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批准号:8293841
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项目类别:
-
资助金额:$23.09万
-
财政年份:--
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负责人:TOR D TOSTESON
-
依托单位:
Methodology Core
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批准号:8917856
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项目类别:
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资助金额:$55.63万
-
财政年份:--
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负责人:TOR D TOSTESON
-
依托单位:
BIOSTATISTICS SHARED RESOURCE
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批准号:8255528
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项目类别:
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资助金额:$18.28万
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财政年份:--
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依托单位:
Methodology Core
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批准号:8712126
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项目类别:
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资助金额:$64.54万
-
财政年份:--
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负责人:TOR D TOSTESON
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依托单位:
BIOSTATISTICS SHARED RESOURCE
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批准号:8376263
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项目类别:
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资助金额:$18.32万
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财政年份:--
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负责人:TOR D TOSTESON
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依托单位:
Methodology Core
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批准号:8500220
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项目类别:
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资助金额:$58.12万
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财政年份:--
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负责人:TOR D TOSTESON
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依托单位:
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批准号:8463398
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项目类别:
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资助金额:$17.17万
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财政年份:--
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负责人:TOR D TOSTESON
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依托单位:
海外基金