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Preconceptual Bisphenol and Phthalate Effects on Early Embryonic Development

孕前双酚和邻苯二甲酸盐对早期胚胎发育的影响

基本信息

批准号：
10554397
负责人：
Leonardo Trasande
金额：
$ 46.71万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10554397
关键词：
Abdomen Academic Medical Centers Acceleration Age Months Aluminum American Biological Assay Biological Markers Birth Butylene Glycols Cardiovascular Diseases Cardiovascular Physiology Chemical Exposure Chemicals Child Childhood Cohort Studies Conceptions Couples Cyclohexanes Data Development Dicarboxylic Acids Diet Dietary Factors Diethylhexyl Phthalate Dimensions EFRAC Echocardiography Elderly Embryo Embryonic Development Embryonic and Fetal Development Endocrine Environmental Exposure Environmental Health Epidemiologist Esters Exposure to Failure Fathers Fatty Liver Fatty acid glycerol esters Fertility Fetal Growth Fetal Growth Retardation First Pregnancy Trimester Future Generations Growth Health Human Impairment Infant International Laboratories Left Length Life Literature Liver Longitudinal Studies Low Birth Weight Infant Maleates Maternal Age Measurement Measures Mediating Methodology Modification Mothers New York Outcome Oxidative Stress Paper Perinatal Phenotype Plastics Pre-Eclampsia Pregnancy Pregnancy Outcome Premature Birth Prenatal care Process Reproductive Technology Risk Factors Sampling Shapes Socioeconomic Status Stroke Volume Subfecundity Succinates Time Ultrasonography United States Urine Ventricular End-Diastolic Volumes Weight Gain Woman Work abdominal fat adverse birth outcomes bisphenol A cardiovascular risk factor cohort early life exposure experience fetal heart dimension/size high risk infertility treatment innovation lifestyle factors male medical schools multi-ethnic novel organ growth oxidant stress phthalates postnatal prenatal prenatal exposure prospective sample collection time-to-pregnancy ultrasound urinary

项目摘要

Project Summary NYU School of Medicine, Erasmus University Medical Center and New York State Department of Health respond to PA-16-160, proposing to study preconception and prenatal phthalate and bisphenol exposures in relationship to time to pregnancy, embryonic and fetal growth, and infant growth. A substantial literature suggests that a diverse array of synthetic chemicals may influence developmental endocrine programming and provoke oxidant stress, a major pathophysiologic mechanism underlying adverse birth outcomes. These include: phthalates (which are used to soften plastics and as scents); and bisphenols (used in aluminum can linings and thermal paper receipts). Yet, longitudinal studies of early life exposure to phthalates and bisphenols and their effects on fetal and postnatal growth in humans have been limited, and the few studies to date have not yielded consistent findings. We propose to analyze samples from preconception, three timepoints in pregnancy (7, 13 and 30 weeks) in 1000 father-mother-infant triads in Generation R Next, a prospective, longitudinal multi-ethnic birth cohort study. Unique embryonic and placental assessments will have been performed through repeated ultrasounds at 7, 9 and 11 weeks. These analyses will also capture embryonic and placental growth as well as liver growth and cardiac size. The proposed study will also leverage echocardiography and abdominal sonography performed at 1 and 12 months of age, which will assess dimensions such as left ventricular end-diastolic volume, end-systolic volume, stroke volume, ejection fraction and mass, as well as abdominal fat and liver steatosis. The PI (Trasande) is an internationally renowned expert in children's environmental health and the proposed study also benefits from strong support from Generation R Next, including the Director (Jaddoe), an experienced pediatric and perinatal epidemiologist with a strong record in studying early determinants of cardiovascular disease. Analyses will be performed by K. Kannan at Wadsworth Laboratories of the New York State Department of Health, who has deep experience with precise measurement of phthalate and bisphenol biomarkers in urine. Given the long-term implications of the “thrifty phenotype,” if preconceptional exposures are found to be important in shaping fetal growth and influencing birth outcomes, then guidance in anticipation of conception to limit environmental exposures before pregnancy may be indicated. Presently, such guidance is limited in the United States, save perhaps from couples seeking advanced reproductive technology.

项目总结