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NYU Pediatric Obesity, Metabolism and Kidney Cohort Center

纽约大学儿科肥胖、代谢和肾脏队列中心

基本信息

批准号：
10471965
负责人：
Leonardo Trasande
金额：
$ 804.95万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-21 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10471965
关键词：
13 year old 2 year old 6 year old 9 year old Abdomen Academic Medical Centers Age-Years Aluminum Aromatic Polycyclic Hydrocarbons Behavioral Biological Biometry Birth Body measure procedure Cardiovascular system Chemical Exposure Chemicals Child Child Development Child Health Childhood Cohort Studies Collection DNA Methylation Data Data Pooling Development Diethylhexyl Phthalate Discipline Disease Environment Environmental Health Environmental Impact Epidemiology Epigenetic Process Exposure to Failure Fatty acid glycerol esters Fetal Growth Fetal Weight First Pregnancy Trimester Funding Gene Expression Generations Glomerular Filtration Rate Gonadal Steroid Hormones Growth Guide prevention Health Human Infant Development Inflammation Influentials Institution Insulin Resistance International Kidney Left Ventricular Mass Leptin Life Literature Longitudinal Studies Magnetic Resonance Imaging Measurement Measures Metabolic Metabolic dysfunction Metabolism Modeling Municipalities Obesity Organ Organophosphates Outcome Outcome Measure Oxidative Stress Paper Pesticides Physiologic pulse Plastics Population Preconception Care Pregnancy Research Role Sampling School-Age Population Serum Spottings Thick Time Toxicology Urine Weight Gain adiponectin base bisphenol A blood pressure elevation cardiometabolic risk cardiometabolism cohort disability endothelial dysfunction fetal flexibility follow-up gene environment interaction human subject insight kidney dysfunction medical schools metabolic phenotype metabolomics neurodevelopment obesity in children oxidant stress perinatal outcomes phthalates postnatal prenatal exposure programs prospective psychosocial public health relevance recruit social standardize measure urinary

项目摘要

Project Summary Progress in elucidating the role of the environment in child development and disability has been slow and incremental. Nearly all studies have examined relatively small populations of children; considered only one parameter at a time; had little power to examine interactions among chemical, social, and behavioral factors; had limited ability to examine gene–environment interactions; and suffered from brief duration of follow-up. NYU School of Medicine and Erasmus University Medical Center, in partnerships with multiple other institutions, respond to RFA-16-OD-004, presenting four cohorts for inclusion in the Environmental Influences on Child Health Outcomes Program (ECHO). These cohorts are the NYU Children's Environmental Health Study (n~1000, 2016–2018 births, NYU CHES); the Rotterdam-based Generation R Second Cohort (n~1000, 2016–2018 births, GR2); the First Generation R Study (n=1431, 2004–2006 births, GR1); and the Infant Development and Environment Study II (n=717, 2010–2012 births, TIDES). Together, they would comprise ~9% of all human subjects within ECHO. All four cohorts are well suited to examination of perinatal outcomes; upper and lower airway; and neurodevelopment, and offer substantial flexibility in prospective collection and the use of existing biospecimens. Though our proposed aims focus on chemical exposures, our cohorts also take a broad approach to biological, psychosocial, and physical exposures, which are equally influential on health outcomes. GR1 is widely known as a model for ECHO, given its track record of successful implementation, much like Project Viva. Moreover, GR1 measures could be used to evaluate the promise and feasibility of common ECHO exposures and outcome measures for use in more recently established cohorts. First-trimester recruitment and collection of urine samples in each trimester are common to all four cohorts. A unique benefit to inclusion of GR2 is its nesting within Rotterdam's municipal preconception care program, permitting examination of preconceptional exposures (generally unavailable in US cohorts). GR1's unique abdominal MRI, pulse wave velocity, and echocardiographic measures permit studies of end-organ effects. ECHO funding would extend NYU CHES and GR2 through age 2 years, GR1 through age 13 years, and TIDES through age 9 years, examining prenatal exposures in relation to early life trajectories of body mass. The proposed NYU-Erasmus ECHO Pediatric Obesity, Metabolism and Kidney Cohort Center pairs an internationally known leader in children's environmental health (Trasande) with a leader in the Developmental Origins of Health and Disease (Jaddoe) as multiple PIs and leverages extensive expertise in fetal growth, epidemiology, biostatistics, metabolomics, epigenetics among other disciplines that contribute to high-quality execution of synthetic cohort studies, and guide prevention.

项目概要阐明环境在儿童发展和残疾中的作用的进展缓慢且增量。几乎所有研究都调查了相对较小的儿童群体；仅考虑一个一次参数；几乎没有能力检查化学、社会和行为因素之间的相互作用；检查基因与环境相互作用的能力有限；并遭受短暂的随访时间。纽约大学医学院和伊拉斯姆斯大学医学中心与其他多个机构合作机构，响应 RFA-16-OD-004，提出四个队列以纳入环境影响儿童健康成果计划 (ECHO)。这些队列是纽约大学儿童环境健康中心研究（n~1000，2016-2018 年出生，NYU CHES）；位于鹿特丹的 R 世代第二队列（n~1000， 2016-2018 年出生人数，GR2)；第一代 R 研究（n=1431，2004-2006 年出生，GR1）；和婴儿发展与环境研究 II（n=717，2010-2012 年出生人数，潮汐）。它们共同构成 ECHO 中约 9% 的人类受试者。所有四个队列都非常适合检查围产期结局；上呼吸道和下呼吸道；和神经发育，并在前瞻性收集和使用现有的生物样本。尽管我们提出的目标侧重于化学品暴露，但我们的团队也对生物、心理社会和身体接触采取广泛的方法，这些接触对健康结果。 GR1 因其成功的记录而被广泛认为是 ECHO 的型号实施，很像 Project Viva。此外，GR1 措施可用于评估承诺和常见 ECHO 暴露和结果测量在最近建立的队列中使用的可行性。妊娠早期的招募和每个妊娠期尿液样本的收集对于所有四个队列来说都是常见的。一个纳入 GR2 的独特好处是它嵌入鹿特丹市的孕前护理计划中，允许检查孕前暴露（在美国队列中通常不可用）。 GR1的独特之处腹部 MRI、脉搏波速度和超声心动图测量可以研究终末器官效应。 ECHO 资助将把 NYU CHES 和 GR2 延长至 2 岁，GR1 延长至 13 岁，以及潮汐直至 9 岁，检查与早期体重轨迹相关的产前暴露。拟议的纽约大学-伊拉斯谟 ECHO 儿童肥胖、代谢和肾脏队列中心将与国际知名的儿童环境健康领域的领导者（Trasande）以及发展方面的领导者健康与疾病的起源 (Jaddoe) 作为多个 PI 并利用胎儿生长方面的广泛专业知识，流行病学、生物统计学、代谢组学、表观遗传学以及其他有助于高质量的学科执行综合队列研究并指导预防。