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NYU Pediatric Obesity, Metabolism and Kidney Cohort Center

纽约大学儿科肥胖、代谢和肾脏队列中心

基本信息

批准号：
10471965
负责人：
Leonardo Trasande
金额：
$ 804.95万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-21 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10471965
关键词：
13 year old 2 year old 6 year old 9 year old Abdomen Academic Medical Centers Age-Years Aluminum Aromatic Polycyclic Hydrocarbons Behavioral Biological Biometry Birth Body measure procedure Cardiovascular system Chemical Exposure Chemicals Child Child Development Child Health Childhood Cohort Studies Collection DNA Methylation Data Data Pooling Development Diethylhexyl Phthalate Discipline Disease Environment Environmental Health Environmental Impact Epidemiology Epigenetic Process Exposure to Failure Fatty acid glycerol esters Fetal Growth Fetal Weight First Pregnancy Trimester Funding Gene Expression Generations Glomerular Filtration Rate Gonadal Steroid Hormones Growth Guide prevention Health Human Infant Development Inflammation Influentials Institution Insulin Resistance International Kidney Left Ventricular Mass Leptin Life Literature Longitudinal Studies Magnetic Resonance Imaging Measurement Measures Metabolic Metabolic dysfunction Metabolism Modeling Municipalities Obesity Organ Organophosphates Outcome Outcome Measure Oxidative Stress Paper Pesticides Physiologic pulse Plastics Population Preconception Care Pregnancy Research Role Sampling School-Age Population Serum Spottings Thick Time Toxicology Urine Weight Gain adiponectin base bisphenol A blood pressure elevation cardiometabolic risk cardiometabolism cohort disability endothelial dysfunction fetal flexibility follow-up gene environment interaction human subject insight kidney dysfunction medical schools metabolic phenotype metabolomics neurodevelopment obesity in children oxidant stress perinatal outcomes phthalates postnatal prenatal exposure programs prospective psychosocial public health relevance recruit social standardize measure urinary

项目摘要

Project Summary Progress in elucidating the role of the environment in child development and disability has been slow and incremental. Nearly all studies have examined relatively small populations of children; considered only one parameter at a time; had little power to examine interactions among chemical, social, and behavioral factors; had limited ability to examine gene–environment interactions; and suffered from brief duration of follow-up. NYU School of Medicine and Erasmus University Medical Center, in partnerships with multiple other institutions, respond to RFA-16-OD-004, presenting four cohorts for inclusion in the Environmental Influences on Child Health Outcomes Program (ECHO). These cohorts are the NYU Children's Environmental Health Study (n~1000, 2016–2018 births, NYU CHES); the Rotterdam-based Generation R Second Cohort (n~1000, 2016–2018 births, GR2); the First Generation R Study (n=1431, 2004–2006 births, GR1); and the Infant Development and Environment Study II (n=717, 2010–2012 births, TIDES). Together, they would comprise ~9% of all human subjects within ECHO. All four cohorts are well suited to examination of perinatal outcomes; upper and lower airway; and neurodevelopment, and offer substantial flexibility in prospective collection and the use of existing biospecimens. Though our proposed aims focus on chemical exposures, our cohorts also take a broad approach to biological, psychosocial, and physical exposures, which are equally influential on health outcomes. GR1 is widely known as a model for ECHO, given its track record of successful implementation, much like Project Viva. Moreover, GR1 measures could be used to evaluate the promise and feasibility of common ECHO exposures and outcome measures for use in more recently established cohorts. First-trimester recruitment and collection of urine samples in each trimester are common to all four cohorts. A unique benefit to inclusion of GR2 is its nesting within Rotterdam's municipal preconception care program, permitting examination of preconceptional exposures (generally unavailable in US cohorts). GR1's unique abdominal MRI, pulse wave velocity, and echocardiographic measures permit studies of end-organ effects. ECHO funding would extend NYU CHES and GR2 through age 2 years, GR1 through age 13 years, and TIDES through age 9 years, examining prenatal exposures in relation to early life trajectories of body mass. The proposed NYU-Erasmus ECHO Pediatric Obesity, Metabolism and Kidney Cohort Center pairs an internationally known leader in children's environmental health (Trasande) with a leader in the Developmental Origins of Health and Disease (Jaddoe) as multiple PIs and leverages extensive expertise in fetal growth, epidemiology, biostatistics, metabolomics, epigenetics among other disciplines that contribute to high-quality execution of synthetic cohort studies, and guide prevention.

项目摘要在阐明环境对儿童发育和残疾的作用方面进展缓慢，增量。几乎所有的研究都只调查了相对较小的儿童群体;只考虑了一个没有能力检查化学、社会和行为因素之间的相互作用; 检查基因-环境相互作用的能力有限;随访时间短。纽约大学医学院和伊拉斯谟大学医学中心，与多个其他合作伙伴，机构，回应RFA-16-OD-004，提出四个群组纳入环境影响儿童健康成果计划（ECHO）这些群体是纽约大学儿童环境健康研究（n~1000，2016-2018出生，纽约大学CHES）;基于鹿特丹的R代第二队列（n~1000， 2016-2018年出生，GR 2）;第一代R研究（n=1431，2004-2006年出生，GR 1）;和婴儿发展与环境研究II（n=717，2010-2012年出生，TIDES）。合在一起， ECHO内所有人类受试者的约9%。所有四个群组都非常适合检查围产期结果; 上和下气道;和神经发育，并在前瞻性收集和使用现有的生物样本。虽然我们提出的目标集中在化学品暴露，我们的队列也采取广泛的方法，生物，心理和身体接触，这是同样有影响的，健康成果。GR 1被广泛认为是ECHO的典范，因为它的成功记录类似于Project Viva。此外，GR 1措施可以用来评估的承诺，在最近建立的队列中使用的常见ECHO暴露和结局指标的可行性。所有四个队列的早期妊娠招募和每个妊娠期的尿液样本收集是共同的。一纳入GR 2的独特好处是它在鹿特丹的市政孕前护理计划中的嵌套，允许检查孕前暴露（美国队列中通常不可用）。GR 1是独一无二的腹部MRI、脉搏波速度和超声心动图测量允许研究终末器官效应。 ECHO的资金将延长纽约大学CHES和GR 2到2岁，GR 1到13岁，潮至9岁，检查产前暴露与早期生活轨迹的身体质量。拟议的纽约大学伊拉斯谟ECHO儿科肥胖，代谢和肾脏队列中心配对，国际知名的儿童环境健康领导者（Trasande），健康和疾病的起源（Jaddoe）作为多个PI，并利用胎儿生长方面的广泛专业知识，流行病学、生物统计学、代谢组学、表观遗传学等有助于高质量的学科开展综合队列研究，指导预防。