The NYU Children’s Health & Environment Study: an ECHO Cohort

纽约大学儿童健康中心

• 批准号: 10745102
• 负责人: Leonardo Trasande
• 金额: $ 859.93万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745102
• 关键词: Air Pollutants; Area; Aromatic Polycyclic Hydrocarbons; Asian; Birth; Black race; COVID-19; COVID-19 pandemic; Chemical Exposure; Chemicals; Child; Child Health; Clinic; Cohort Studies; Collection; Complement; Conceptions; Couples; Data; Data Collection; Development; Discipline of obstetrics; Embryo; Enrollment; Environment; Environmental Exposure; Environmental Health; Exposure to; Fertility; Fetal Growth; Funding; Future Generations; Generations; Growth; Health; Hispanic; Human; Infant; International; Laboratories; Lead; Life; Long-Term Effects; Low Birth Weight Infant; Measures; Mediating; Melamine; Mothers; National Institute of Environmental Health Sciences; New York City; Obesity; Organophosphates; Outcome; Participant; Patients; Personal Satisfaction; Persons; Pesticides; Phase; Pilot Projects; Plethysmography; Pregnancy; Pregnancy Outcome; Pregnant Women; Premature Birth; Procedures; Productivity; Protocols documentation; Publications; Recommendation; Research; Resources; Risk Factors; Roentgen Rays; SARS-CoV-2 infection; Sampling; Science; Subfecundity; System; Time; Translations; United States National Institutes of Health; Urine; Visit; absorption; chemical association; cohort; design; development policy; digital platform; experience; fetal; follow-up; heterocyclic aromatic amines; infancy; infertility treatment; innovation; medical schools; novel; pandemic disease; participant retention; patient engagement; phthalates; postnatal; pregnant; prenatal; prenatal exposure; programs; public health insurance; recruit; time-to-pregnancy; wearable device; working group

PROJECT SUMMARY NYU Grossman School of Medicine (NYUGSOM) presents an application for: (1) ongoing enrollment of pregnancies, conceiving partners and their children from the NYU Children’s Health and Environment Study (NYU CHES, UG3/UH3OD023305) into the Environmental influences on Child Health Outcomes Program (ECHO) Cohort, (2) follow up of already enrolled mother-infant pairs and (3) piloting of the ECHO preconception study. NYU CHES enrolls pregnant people <18 weeks gestation from NYUGSOM-affiliated obstetric clinics. The cohort is diverse ( 50% Hispanic, 9.7% Asian, 5.2% Black; 49% Public Insurance ) and Over the past seven years, we exceeded our expected enrollment by over 100% (>2000 mother-child pairs compared with the planned 1000). We sustained strong retention despite the COVID-19 pandemic, with nearly 72-83% visit completion at each of five time points in infancy (4-7, 8-11, 12-27, 18-23 and 24-35 months) and biospecimen collection rates as high as 80% in pregnancy. We contributed substantially to ECHO-wide science, with an emphasis on chemical/physical environmental exposures (our Specialized Exposure area). PI Trasande was the inaugural co-chair of the Obesity Working Group, and NYU CHES contributed specialized measures of obesity (our Specialized Outcome area) through the application of plethysmography and dual-absorption X-ray absorptiometry. We vigorously responded to the pandemic by co-leading the COVID-19 Working Group, completing a multi-cohort study of SARS-CoV-2 infection and birth outcomes supported by an ECHO Supplement, and obtaining funding from the NIH RECOVER Initiative to identify long-term effects of SARS-CoV-2 infection in children. Our scientific productivity is manifested not only in our 32 cohort-specific publications, but more importantly in our contribution to a plethora of ECHO-wide publications that span all five of ECHO’s outcomes. We propose to continue our enrollment of new pregnancies at the rate we achieved during the previous funding period (520 mother-child pairs/year). We will continue to implement the ECHO Cohort Data and Biospecimen Collection Protocol and its central data capture system (REDCap Central) among all participants. We anticipate enrolling 200 NYU CHES mothers and their partners each year into the Preconception Pilot Study as soon as feasible after delivery. We suggest innovative science for the pregnancy and preconception cohorts, including expanding our study of chemical and physical exposures to include novel contaminants such as heterocyclic aromatic amines and melamine, led by Co-I Kannan, who directs a NIEHS Human Health Exposure Analysis Resource laboratory (U2CES026542). We apply an innovative digital platform for participant engagement, retention and data collection developed by Vibrent Health for the NIH All of Us Study, which we recommend for broader application in the ECHO Program. PI Trasande is an international leader in children’s environmental health (CEH) and directs an NIEHS Collaborative Center in CEH Research and Translation. broadly representative of NYC pregnancies.

项目摘要 纽约大学格罗斯曼医学院（NYUGSOM）提出申请：（1）正在进行的招生 纽约大学儿童健康与环境研究中的怀孕、怀孕伴侣和他们的孩子 (NYU CHES，UG 3/UH 3 OD 023305）纳入环境对儿童健康结果的影响项目 （ECHO）队列，（2）对已登记的母婴对进行随访，（3）ECHO试点 前概念研究NYU CHES招收来自NYUGSOM附属机构的妊娠<18周的孕妇 产科诊所。队列是 多样性（ 50%西班牙裔，9.7%亚裔，5.2%黑人; 49%公共保险 ）和 在过去的七年里，我们超过了预期的入学人数， 超过100%（超过2 000对母子，而计划为1 000对）。我们保持了强大的保留力， 尽管COVID-19大流行，在婴儿期的五个时间点（4-7， 8-11，12-27，18-23和24-35个月），生物标本采集率高达80%。我们 为ECHO范围内的科学做出了重大贡献，重点是化学/物理环境 曝光（我们的专业曝光区域）。PI Trasande是肥胖工作组的首任联合主席， 集团和纽约大学CHES通过以下方式贡献了肥胖的专门措施（我们的专门成果领域）： 体积描记法和双吸收X线吸收法的应用。我们积极回应 通过共同领导COVID-19工作组，完成SARS-CoV-2的多队列研究， 由ECHO补充支持的感染和出生结果，并从NIH获得资金 RECOVER Initiative旨在确定SARS-CoV-2感染对儿童的长期影响。我们的科学 生产力不仅体现在我们的32个特定群体的出版物，但更重要的是， 为涵盖ECHO所有五项成果的ECHO范围内的大量出版物做出了贡献。我们建议 继续以我们在上一个资助期（520）达到的速度招募新怀孕者 母子对/年）。我们将继续实施ECHO队列数据和生物样本采集 在所有参与者中使用议定书及其中央数据采集系统（REDCap Central）。我们预计 每年有200名纽约大学的母亲和她们的伴侣尽快参加孕前试点研究 分娩后。我们建议对怀孕和孕前人群进行创新科学研究，包括 扩大我们对化学和物理暴露的研究，包括新的污染物，如杂环 芳香胺和三聚氰胺，由负责NIEHS人类健康暴露分析的Co-I Kannan领导 资源实验室（U2 CES 026542）。我们为参与者的参与应用了一个创新的数字平台， 由Vibrent Health为NIH All of Us研究开发的保留和数据收集，我们建议用于 在ECHO计划中应用更广泛。PI Trasande是儿童环境保护领域的国际领导者 健康（CEH），并指导CEH研究和翻译的NIEHS合作中心。 代表了纽约市的怀孕情况。