Mouse Models Core D

鼠标型号 Core D

基本信息

批准号：
10555245
负责人：
Fabio Cominelli
金额：
$ 23.76万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-02-15 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10555245
关键词：
3-Dimensional Adoptive Transfer Anesthesia procedures Animals Area Bone Marrow Breeding CRISPR/Cas technology Chemicals Chimera organism Chronic Clinic Colitis Colitis associated colorectal cancer Collaborations Colonic Neoplasms Colonic inflammation Communities Complex Consult Consultations Core Facility Cost Savings Couples Development Digestive System Disorders Disease Education Endoscopy Evaluation Evolution Fostering Funding Funding Opportunities Genes Goals Hemoglobin Hepatitis Hepatocarcinogenesis Histology Human Resources Ileocolitis Image Immunologics Individual Inflammation Inflammatory Investigation Joints Large Intestine Light Liver Liver diseases Magnetic Resonance Imaging Mediating Metabolic Diseases Metabolism Methodology Methods Midwestern United States Modeling Mus Mutation Obesity Pathogenesis Performance Peroxidases Productivity Proteins Protocols documentation Publications Qualifying RNA Randomized Recovery Reproducibility Research Research Institute Research Personnel Research Project Grants Research Support Resolution Resource Sharing Resources Sampling Service delivery model Services Small Intestines Standardization Surveys System Techniques Technology Testing Tissue Harvesting Tissues Training Universities Visual Visualization cell type chromoscopy cohort commune cost cost effective digital effectiveness evaluation experimental group experimental study flexibility gastrointestinal gut inflammation imaging capabilities improved in vivo liver inflammation meetings member metabolic abnormality assessment metabolic phenotype mouse model nano-string new technology operation preclinical study programs research and development research facility treatment effect treatment group tumor tumorigenesis

项目摘要

MOUSE MODELS CORE D PROJECT SUMMARY The objective of the Cleveland DDRCC Mouse Models Core is to provide a comprehensive set of cost-effective services and shared resources to DDRCC investigators that augments their performance of in vivo studies focused on the pathogenesis of Digestive Inflammation/Tumorigenesis and Liver Disease/Metabolism. The overall goal of this Core is to provide centralized mouse modeling services that will enhance the pace of in vivo digestive disease-related research at Case Western Reserve University and the Cleveland Clinic Lerner Research Institute and provide communal, cost-effective access to unique mouse models on intestinal inflammation and liver disease, thus resulting in new research projects, funding opportunities, and collaborations in these areas of investigation. During the past funding cycle, the Core has been successful, with an increase in the number of Core users and several important publications supported by the Core. The Cleveland DDRCC Mouse Models Core achieves these goals through the following specific aims: (1) Provide experimental cohorts of SAMP1/YitFc and TNFARE mice to Center members, other DDRCCs, and the US scientific community; (2) Educate, consult, and train DDRCC investigators in the use of various mouse modeling techniques; (3) Provide high-resolution murine video endoscopy with well-validated scoring of intestinal inflammation and colonic tumors; (4) Quantify murine intestinal inflammation by 3-D stereomicroscopy with assessment of myeloperoxidase activity; and (5) Interface with the Case Mouse Metabolic Phenotyping Center to support DDRCC investigators performing murine metabolic studies and provide joint educational programs on new technologies available for the study of murine inflammatory and metabolic diseases. The DDRCC Mouse Models Core Steering Committee meets monthly to discuss operational issues. The Core presents its operations to the DDRCC Executive Committee at their quarterly meetings to evaluate the effectiveness of existing services against the evolving needs of the DDRCC membership so that the Core brings the most benefit to the Center members and the scientific themes of the Cleveland DDRCC. Thus, the Mouse Models Core benefits DDRCC members by providing a combination of uniquely available resources and cost-effective services that facilitate the development of research related to digestive diseases in the Cleveland scientific community and beyond.

鼠标模型核心D项目摘要克利夫兰DDRCC鼠标模型核心的目的是提供一组全面的成本效益服务和向DDRCC调查人员共享资源，以增强其体内研究的性能着眼于消化炎症/肿瘤发生和肝病/代谢的发病机理。这该核心的总体目标是提供集中的鼠标建模服务，以增强体内的步伐 Case Western Reserve University和Cleveland Clinic Lerner的消化疾病有关的研究研究所，并在肠道上提供对独特的鼠标模型的公共，具有成本效益的访问炎症和肝病，从而导致新的研究项目，资助机会和这些投资领域的合作。在过去的资金周期中，核心已经成功，随着核心用户数量的增加和核心支持的几个重要出版物。这克利夫兰DDRCC鼠标模型核心通过以下特定目的实现这些目标：（1）提供 SAMP1/YITFC和TNFARE小鼠的实验人群，用于中心成员，其他DDRCC和美国科学界；（2）教育，咨询和培训DDRCC调查人员使用各种鼠标建模技术；（3）提供高分辨率的鼠视频内窥镜检查，并进行验证的评分肠炎和结肠肿瘤；（4）通过3-D量化鼠肠炎立体显微镜检查，评估骨髓过氧化物酶活性；（5）与案例鼠标接口代谢表型中心支持DDRCC研究人员进行鼠代谢研究和提供有关用于研究鼠炎症和研究的新技术的联合教育计划代谢疾病。 DDRCC鼠标核心指导委员会每月开会讨论操作问题。核心在其季度向DDRCC执行委员会提供了运营开会以评估现有服务对DDRCC不断发展的需求的有效性会员资格，以便核心给中心成员和科学主题带来最大的好处克利夫兰DDRCC。这是鼠标模型核心通过提供的组合来使DDRCC成员的组合受益独特可用的资源和具有成本效益的服务，促进与克利夫兰科学界及其他地区的消化疾病。